Category: 924-99-2

Beck, James R. published the artcileSynthesis of 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acids and esters, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Journal of Heterocyclic Chemistry (1987), 24(3), 739-40, database is CAplus.

Et 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylates I (R¹ = H, Cl, CF₃, OMe) were prepared by the condensation of arylhydrazines with Et 3-ethoxy-2-(trifluoroacetyl)-2-propenoate at low temperature The corresponding acids were also synthesized.

Journal of Heterocyclic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guo, Xiao-hong published the artcileSynthesis of rufloxacin hydrochloride, Application In Synthesis of 924-99-2, the publication is Zhongguo Yaoye (2008), 17(10), 24-25, database is CAplus.

A method for the synthesis of the title compound [i.e., 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid hydrochloride] is reported here.

Zhongguo Yaoye published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application In Synthesis of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Song, Runzhe published the artcileDesign and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Quality Control of 924-99-2, the publication is Bioorganic Chemistry (2020), 104176, database is CAplus and MEDLINE.

The desfluoroquinolone-based hybrids with involvement of C-7 aminopyrimidine functional group were designed and synthesized. The biol. results showed majority of these hybrids still demonstrated potent anti-MRSA activity with MIC values between 0.38 and 1.5μg/mL, despite the lack of the typical C-6 fluorine atom. Particularly, the most active 1-cyclopropyl-7-((4-(3,4-dimethylphenoxy)pyrimidin-2-yl) amino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid exhibited activities at submicromolar concentrations against a panel of MRSA strains including vancomycin-intermediate strains, levofloxacin-resistant isolates, and linezolid-resistant isolates, etc. As expected, it also displayed highly selective toxicity toward bacterial cells and low hERG inhibition. Further resistance development study indicated MRSA is unlikely acquired resistance against 1-cyclopropyl-7-((4-(3,4-dimethylphenoxy)pyrimidin-2-yl)amino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. The docking study revealed that two hydrogen bonds were formed between the C-7 substituent and the surrounding DNA bases, which contributed to resistance by reducing the dependence on the magnesium-water bridge interactions with topoisomerase IV. These indicated a promising strategy for developing new antibiotic quinolones to combat multidrug resistance and cardiotoxicity was resulted.

Bioorganic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C9H7NO3, Quality Control of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhou, You published the artcileI₂-Promoted site-selective C-C bond cleavage of aryl methyl ketones as C1 synthons for constructing 5-acyl-1H-pyrazolo[3,4-b]pyridines, COA of Formula: C7H13NO2, the publication is Organic Chemistry Frontiers (2022), 9(16), 4416-4420, database is CAplus.

A novel iodine promoted [1 + 3 + 2] cleavage cyclization reaction for the synthesis of 1H-pyrazolo[3,4-b]pyridines from aryl Me ketones, 5-aminopyrazoles and enaminones was established. This transition metal-free catalysis method has simple reaction conditions and good substrate compatibility, and was demonstrated in the transformation of alkyl and natural mol.-derived enaminones. Mechanistic studies showed that two cyclization pathways affording different key intermediates were involved, but affording the same target product after site-selective cleavage of the unstrained C-C bond of the acyl group.

Organic Chemistry Frontiers published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C16H24BNO2, COA of Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kantlehner, Willi published the artcileOrthoamides. XXXII. Reaction of tert-butoxy-N,N,N’,N’-tetramethylmethanediamine with NH- and CH-acidic compounds, Computed Properties of 924-99-2, the publication is Liebigs Annalen der Chemie (1980), 344-57, database is CAplus.

Me₃COCH(NMe₂)₂ (I) reacted with OHCNHCH₂(CH₂)_nCO₂Et to give OHCNH(CH₂)_nC(CO₂Et):CHNMe₂, whereas H₂NCH₂CO₂Et reacted with I to give Me₂NCH:NCH₂CO₂Et, which reacted with I to give Me₂NCH:NC(CO₂Et):CHNMe₂. HCONHR (R = Me, Et, Ph, Pr, PhCH₂) were transformed by I into Me₂NCH:NR. Reaction of EtO₂CCH₂NC with I gave EtO₂CC(NC):CHNMe₂, whereas reaction of PhCH₂NC with I gave Me₂NCH:CPhN:CHNMe₂. The oxazolines II (R = H, Me), R¹N:C(OEt)CH₂R² (R¹, R² = Me, Ph; Ph, H), and Me₂NCMe:NR³ (R³ = Me, Ph) were aminomethylated by I to give III, Me₂NCH:CR²C(OEt):NR¹, and R³N:C(NMe₂)CH:CHNMe₂, resp. MeC⁺(NMe₂)₂BF₄^– reacted with I to give Me₂NCH:CHC⁺(NMe₂)₂BF₄^–, whereas R⁴CH₂P(O)(OEt)₂ (R⁴ = Ph, CO₂Et, cyano) reacted with I to give Me₂NCH:CR⁴P(O)(OEt)₂. Reaction of I with Me₃SiCH₂CO₂Et yielded Me₂NCH:CHCO₂Et.

Liebigs Annalen der Chemie published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zheng, Xixi published the artcileThe C=C Bond Decomposition Initiated by Enamine-Azide Cycloaddition for Catalyst- and Additive-Free Synthesis of N-Sulfonyl Amidines, Related Products of esters-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2019), 361(24), 5690-5694, database is CAplus.

The chemo-selective synthesis of N-sulfonyl amidines is realized via the decomposition of the enamine C=C bond of enaminoesters through an in situ generated triazoline intermediate. Control experiments prove that the electron withdrawing ester group in the enamine component is crucial in inducing the chemo-selective formation of amidines. The method is featured with high efficiency and sustainability by employing pure water as medium without requiring any catalyst or additive.

Advanced Synthesis & Catalysis published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C26H45N5O7Si2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Trawneh, Salah A. published the artcileSynthesis and cytotoxicity of thieno[2,3-b]pyridine derivatives toward sensitive and multidrug-resistant leukemia cells, Computed Properties of 924-99-2, the publication is Acta Chimica Slovenica (2021), 68(2), 458-465, database is CAplus and MEDLINE.

A new series of substituted Et 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates I (R = H, CHO; X = H, 4-Me, 4-Cl; Y = O, S) were prepared by utilizing Et 2-chloro-7-cyclopropyl-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (1) and replacing of the 2-chlorine with anions obtained from phenol, salicylaldehyde derivatives like salicylaldehyde, 5-methylsalicylaldehyde and 5-chlorosalicylaldehyde or thiophenol, leading to the resp. Et 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates I. The new compounds I were evaluated for their in vitro cytotoxicity towards sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells. The screening revealed that compounds I (R = X = H, Y = O; R = CHO, X = H, Y = O; R = X = H, Y = S) inhibited the growth of both cell lines. Compound I (R = CHO, X = H, Y = O), with a phenol moiety, exhibited the highest growth inhibitory activity against CEM/ADR5000 and CCRF-CEM cells with IC₅₀ values 4.486 ± 0.286 and 2.580 ± 0.550μM, resp. Collectively, the presented results demonstrate that the synthesized thieno[2,3-b]pyridines I warrant further exploration for potential use as anti-cancer agents.

Acta Chimica Slovenica published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cecchetti, Violetta published the artcileStudies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino-8-methoxyquinolones, Computed Properties of 924-99-2, the publication is Bioorganic & Medicinal Chemistry (1999), 7(11), 2465-2471, database is CAplus and MEDLINE.

From our quant. structure-activity relationship (QSAR) study on a large set of 6-aminoquinolones, which indicated that a group larger than Me could be allocated at C-8 position, we have synthesized two new series of 6-aminoquinolones characterized by the presence of an Et or a methoxy group at C-8 position. The antibacterial evaluation shows that, while the 8-Et derivatives were devoid of any antibacterial activity, the introduction of methoxy group gave compounds with good antibacterial activity, especially against Gram-pos. bacteria. A tentative explanation of the different behaviors among the 8-substituted analogs is given taking into account both the length and electronic properties of the C-8 groups.

Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Van Es, Theodorus published the artcileN,1-Dialkyl-7-(alkylamino)-4-(alkylimino)-1,4-dihydroquinoline-3-carboxamides and their 4-oxo derivatives: synthesis and properties, Computed Properties of 924-99-2, the publication is South African Journal of Chemistry [online computer file] (2001), 1-16, database is CAplus.

Methods are described for accessing the little known class of 4-alkyliminoquinoline-3-carboxamide title compounds; viz., from 4-oxoquinoline-3-carboxylic acids treated successively with thionyl chloride and amine, from 4-oxoquinoline-3-carboxylic esters treated likewise, and from the hydrogen chloride salt of a 4-alkyliminoquinoline-3-carboxylic ester and amine. Mechanistic aspects of the syntheses are discussed, and some spectroscopic and chem. properties of the title compounds are presented.

South African Journal of Chemistry [online computer file] published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C13H9FO, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tabarrini, Oriana published the artcileStructure Modifications of 6-Aminoquinolones with Potent Anti-HIV Activity, COA of Formula: C7H13NO2, the publication is Journal of Medicinal Chemistry (2004), 47(22), 5567-5578, database is CAplus and MEDLINE.

It was recently discovered that 6-aminoquinolone derivatives could be valid leads for the development of new anti-HIV agents because of their new and diversified mode of action. The studies carried out on the lead compound WM5 showed that this derivative is able to inhibit the Tat-mediated long terminal repeat driven transcription, an essential step in the HIV-1 replication cycle. Thus, starting from lead WM5, the design and synthesis of an enlarged series of 6-aminoquinolones, e.g. I (R¹ = Me, 2-benzothiazolyl, biphenyl, 4-FC₆H₄, etc.; R² = 2-MeOC₆H₄, 2-thiazolyl, 2-pyridyl, 5-methyl-1,3,4-thiadiazol-2-yl, etc.), was performed and their structure-activity relationship was studied. I (R¹ = Me; R² = 3-F₃CC₆H₄, 2-thiazolyl, 2-pyrazinyl, 2-benzoxazolyl) proved to be highly effective in inhibiting HIV replication at 50% inhibitory concentration in the range of 0.0087-0.7 μg/mL in MT-4, PBMCs and CEM cell lines coupled with pos. selectivity indexes that reach values higher than 1000 on CEM cell lines for I (R¹ = Me; R² = 2-thiazolyl, 2-pyrazinyl). Time-of-addition experiments clearly confirm that the new, potent 6-aminoquinolones interact at a postintegration step in the replication cycle of HIV.

Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H15NO, COA of Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics