Category: 924-99-2

Hong, Jian published the artcileA novel approach to finafloxacin hydrochloride (BAY35-3377), Formula: C7H13NO2, the publication is Tetrahedron Letters (2009), 50(21), 2525-2528, database is CAplus.

Finafloxacin.HCl, an important clin. compound was synthesized by a novel synthetic approach. The active intermediate 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate was prepared by a new route. The chiral (S,S’)-N-Boc-pyrrolidinomorpholine I was derived from protected pyrrolidine, and its absolute stereochem. was established by x-ray anal.

Tetrahedron Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ma, Shuai published the artcileSynthesis of elvitegravir, SDS of cas: 924-99-2, the publication is Zhongguo Yiyao Gongye Zazhi (2014), 45(1), 5-8, database is CAplus.

Elvitegravir was synthesized from 2,4-difluorobenzoic acid via iodization, acylation and condensation to give Et 2-(2,4-difluoro-5-iodobenzoyl)-3-dimethylaminoacrylate, which was subjected to addition-elimination with L-valinol, cyclization, protection with tert-butyldimethylsilyl chloride and Negishi coupling reaction with 3-chloro-2-fluorobenzylzinc bromide, followed by one-pot synthesis including deprotection, hydrolysis and methoxylation with an overall yield of about 42%.

Zhongguo Yiyao Gongye Zazhi published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhuo, Jin-Cong published the artcile¹⁷O NMR spectra of α,β-unsaturated carbonyl compounds RCH=CHCOX: the influence of group X on the δ(¹⁷O) value of the carbonyl oxygen and on the shielding effect of group R, Formula: C7H13NO2, the publication is Molecules [Electronic Publication] (1999), 4(11), 320-328, database is CAplus.

¹⁷O NMR spectra of 26 X (R = Me, Ph), 40 RCH:CHCOX (I; R = H, Ph, Me, EtO₂C) and 4 Me₂C:CHCOX (X = H, Me, Et, CHMe₂, CMe₃, Ph, CH:CHPh, OMe, OEt, Cl, cyano, CF₃, CO₂Et) are reported. The ¹⁷O shift values of these carbonyl compounds depend mainly on the electron-donating power of X and correlate well with the resonance consts, σ_R⁺ of X. This suggests that the δ(¹⁷O) values can be used to reflect qual. the electrophilicity of the carbonyl group. The shielding effect of the substituent R in I is diminished with increasing electron-donating power of X and correlates with σ⁺ values of X.

Molecules [Electronic Publication] published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H17NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Qawasmeh, Raed A. published the artcileSynthesis and antibacterial activity of 9-cyclopropyl-4-fluoro-6-oxo-6,9-dihydro-[1,2,5]thiadiazolo[3,4-h]quinoline-7-carboxylic acid and its ethyl ester, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is ARKIVOC (Gainesville, FL, United States) (2009), 322-336, database is CAplus.

Synthesis and the antimicrobial activity of 9-cyclopropyl-4-fluoro-6-oxo[1,2,5]thiadiazolo[3,4-h]quinoline-5-carboxylic acid (I) and Et ester are reported. Compound I was prepared in good yield via thermal cyclocondensation of Et 7,8-diamino-9-cyclopropyl-4-fluoro-6-oxoquinoxaline-7-carboxylate with thionyl chloride, followed by acid-catalyzed hydrolysis. The structures of all synthesized compounds were characterized by IR, MS, ¹H- and ¹³C NMR spectra; the structure of compound I was confirmed by X-ray crystal structure anal. The antibacterial and antifungal evaluation against a broad panel of wild and resistant Gram-pos. and Gram-neg. bacteria and fungal species demonstrated the high antibacterial activity of compound I, even at the concentration of 0.015 μg mL^-1.

ARKIVOC (Gainesville, FL, United States) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Safety of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Deqing published the artcileBiaryl and atropisomeric biaryl aldehyde synthesis by one-step, metal-free benzannulation of aryl enals and propiolates, Formula: C7H13NO2, the publication is Green Chemistry (2020), 22(20), 6773-6777, database is CAplus.

A new method involving the benzannulation of aromatic enals ArCH=CHCHO (Ar = C₆H₅, 2-furyl, 1-naphthyl, etc.) and two alkyl propiolate mols. CHCC(O)₂R (R = Me, Et, t-Bu) has been developed as a powerful route to biaryl aldehydes I simply via the promotion of di-Me amine. The benzannulation process in the absence of an oxidant additive tolerates successfully the formyl group in the enal component, leading to a straightforward one-step synthesis of biaryl and atropisomeric aldehydes I. An enamine activation based on the aza-Michael addition of di-Me amine to the propiolate and the amine elimination-based generation of cyclohexadiene intermediate constitute the major factors enabling the titled reactions.

Green Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Jiu published the artcileTechnical improvement for synthesis of levofloxacin, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is Guangzhou Huagong (2012), 40(9), 118-120, database is CAplus.

The levofloxacin process was optimized. Levofloxacin was prepared with 2,3,4,5-tetrafluorobenzoyl chloride as the starting material, by acylation, amination, and cyclization left oxyfluoride cyclization ester was obtained, and then Piperazine and left oxyfluoride cyclization ester condensation, after methylation by di-Me sulfate, hydrolysis, condensation. Comparing to the old process, Piperazine instead of N-methylpiperazine, process was improved with many advantages, such as improving the yield and quality of the product, reducing the cost, reducing environmental pollution, and tech. indicators in line with the CP2010 Levofloxacin requirements.

Guangzhou Huagong published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C13H11NO, Safety of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yu, Zhiqun published the artcileBronsted acid-catalyzed chlorination of aromatic carboxylic acids, Product Details of C7H13NO2, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2021), 196(8), 685-689, database is CAplus.

The chlorination of aromatic carboxylic acids with SOCl₂ has been effectively performed by reacting with a Bronsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl₂/Bronsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl₂/Bronsted acid.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C6H5BN2O3, Product Details of C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Li-feng published the artcileSynthesis of 3-difluoromethyl-1-methyl-1H-pyrazol-4-carboxylic acid, HPLC of Formula: 924-99-2, the publication is Jingxi Huagong Zhongjianti (2013), 43(6), 17-19, 47, database is CAplus.

3-Difluoromethyl-1-methyl-1H-pyrazol-4-carboxylic acid was prepared in overall yield of 52% with purity of 98% (HPLC) starting from propargyl alc. through several reaction steps including oxidation, esterification, addition, methylation and hydrolysis.

Jingxi Huagong Zhongjianti published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Geng, Xiao published the artcileVisible-Light-Driven Multicomponent Cyclization by Trapping a 1,3-Vinylimine Ion Intermediate: A Direct Approach to Pyrimido[1,2-b]indazole Derivatives, Category: esters-buliding-blocks, the publication is Organic Letters (2021), 23(21), 8343-8347, database is CAplus and MEDLINE.

Here a novel visible-light-driven three-component cyclization by trapping an 1,3-vinylimine ion intermediate for the direct synthesis of pyrimido[1,2-b]indazole derivatives from bromodifluoroacetic acid derivatives, enaminones, and 3-aminoindazoles under mild conditions was developed. Notably, the robust methodol. provided a valuable opportunity for the introduction of aliphatic substituents and enables good compatibility of complex bioactive mols. Furthermore, this was the first example of photoinduced multicomponent reaction by employing bromodifluoroacetic acid derivatives as a C1-synthon.

Organic Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kong, Jiahui published the artcilePreparation of the key dolutegravir intermediate via MgBr2-promoted cyclization, Related Products of esters-buliding-blocks, the publication is Molecules (2021), 26(10), 2850, database is CAplus and MEDLINE.

A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr₂-promoted intramol. cyclization. Condensation of com. available Me oxalyl chloride and Et 3-(N,N-dimethylamino)acrylate afforded the vinylogous amide in an excellent yield. Subsequent substitution by aminoacetaldehyde di-Me acetal and Me bromoacetate gave rise to the expected precursor for cyclization, which was promoted by MgBr₂ to highly selectively convert into pyridinone diester. The key dolutegravir intermediate was finally prepared by the selective hydrolysis of the corresponding diester via LiOH.

Molecules published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics