Application of 921222-14-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 921222-14-2 name is Ethyl 2,3-diamino-6-(methylthio)benzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2,3-diamino-6-methylsulfanyl-benzoic acid ethyl ester (150 mg) in acetonitrile (10 mL) are added 2,3-dichlorophenyl isothiocyanate (98 muL). The reaction mixture obtained is stirred 1 hour at RT and N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydro-chloride (EDCI, 166 mg) is added. The mixture obtained is cooled to RT, quenched with H2O and extracted with EtOAc. The organic layers obtained are combined, dried over MgSO4, filtrated and solvent is evaporated to afford the title compound (LC/MS Rt=3.55, [M]+=395.93 and 397.89 and 399.89).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2,3-diamino-6-(methylthio)benzoate, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/9774; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics