Category: 91085-56-2

Reference of 91085-56-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 91085-56-2 name is Ethyl 3,5-dichlorobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Ethylbenzoates (11-15, 1.5g, 9.98 mmol)and ethyl-2-phenylacetates (16-20, 1.5g, 9.13 mmol)were dissolved in ethanol and then hydrazine-hydrate(99%) was added and reux for 8-12h. Ethanol wasconcentrated and the resultant residue was pouredin ice cold water and stirred for 15 -20 min, the solidsthat were thrown out was fltered at the pump anddried to obtain the corresponding benzohydrazides(21-25) and 2-phenylacetohydrazides (26-30) in 80-82% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 3,5-dichlorobenzoate, and friends who are interested can also refer to it.

Reference:
Article; Kumar Reddy; Kathale, Niren E.; Oriental Journal of Chemistry; vol. 33; 2; (2017); p. 971 – 978;,
Ester – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 91085-56-2, name is Ethyl 3,5-dichlorobenzoate, A new synthetic method of this compound is introduced below., name: Ethyl 3,5-dichlorobenzoate

5,6-Dihydro-cyclopenta[b]thiophen-4-one (2.1 g, 15.0 mmol) in 15 ml of THF was treated with NaH (60 percent, 1.5 g, 36 mmol). After the addition of 3,5-Dichloro-benzoic acid ethyl ester, the reaction mixture was heated at 100 C. for 8 hr. The solution was cooled to room temperature and poured into water. The resulting mixture was acidified with concentrated HCl and was added with ethyl acetate (70 mL). The organic layer was collected, brined, dried over MgSO4(s), and concentrated under reduced pressure. The resultant precipitate was collected and recrystallized from ethanol to provide the corresponding 5-(3,5-Dichloro-benzoyl)-5,6-dihydro-cyclopenta[b]thiophen-4-one (1.5 g, 4.8 mmol) as brown solid in 34% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DEVELOPMENT CENTER FOR BIOTECHNOLOGY; LIAO, Chu-Bin; CHIANG, Chao-Cheng; YANG, Huei-Ru; LIAO, Yuan-Chun; CHEN, Paonien; US2013/274255; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 91085-56-2, name is Ethyl 3,5-dichlorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of Ethyl 3,5-dichlorobenzoate

Ethyl 3,5-dichlorobenzoate (8.4 g, 38.3 mmol) and sodiumhydride (1.1 g, 46.0 mmol) were dissolved in 100 mL THF underN2. To the mixture was added 13.2 mL ethyl propionate slowly atroom temperature and refluxed overnight. The solvent wasremoved under reduced pressure. The residue was extracted withethyl acetate, washed with water and brine and dried over Na2SO4.Flash column chromatography gave 9.7 g (92%) ethyl 3-(3,5-dichlorophenyl)-2-methyl-3-oxopropanoate 5 as orange solid. 1HNMR (400 MHz, DMSO-d6) d 7.97 (t, J = 3.3 Hz, 3H), 4.80 (q, J =6.9 Hz, 1H), 4.07 (q, J = 7.1 Hz, 2H), 1.31 (d, J = 6.9 Hz, 3H), 1.08(t, J = 7.1 Hz, 3H). MS (ESI, m/z): 274.0 [MH].

The synthetic route of 91085-56-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shu, Shuangjie; Dai, Antao; Wang, Jiang; Wang, Bin; Feng, Yang; Li, Jia; Cai, Xiaoqing; Yang, Dehua; Ma, Dakota; Wang, Ming-Wei; Liu, Hong; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1896 – 1908;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics