Category: 91-44-1

Application of 91-44-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 91-44-1, name is 7-(Diethylamino)-4-methyl-2H-chromen-2-one belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a typical reaction, a Schlenk tube charged with coumarins (0.5mmol), dialkyl phosphite (1.0mmol), NHC palladium complex, AgNO3 and solvent (2mL) was heated at 80C for 10h. The mixture was then cooled, filtered and the filtrate was evaporated. Purification of the residue by column chromatography (silica, petroleum ether/ethylacetate=2/1-1/4, v/v) produced the pure products, which were characterized by 1H NMR and 13C NMR. The analytical data of the products were shown in the Supporting Information.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-(Diethylamino)-4-methyl-2H-chromen-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yang, Liangru; Zhang, Xinchi; Yuan, Jinwei; Xiao, Yongmei; Mao, Pu; Journal of Organometallic Chemistry; vol. 818; (2016); p. 179 – 184;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 91-44-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 91-44-1 as follows.

To a 50 mL round bottom flask containing acetonitrile (20 mL) was added 7-(diethylamino)-4-methylcoumarin (1.01 g, 4.37 mmol). Then N-bromosuccinimide (0.86 g, 4.8 mmol) was added in portions. After stirring at room temperature for 23 h, the reaction mixture was poured into water after the reaction was completed. The organic phase was extracted three times with ethyl acetate and dried over anhydrous sodium sulfate. The solvent was removed by evaporation to give a yellow powder.

According to the analysis of related databases, 91-44-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sun Yat-sen University; Song Huacan; Cao Wenyan; Song Senchuan; Liu Jiarong; (18 pag.)CN109574942; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 91-44-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 91-44-1 name is 7-(Diethylamino)-4-methyl-2H-chromen-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a Schlenk tube, coumarin 1 (0.5mmol), dialkyl H-phosphite 2 (1.0mmol), AgNO3 (0.025mmol, 4.2mg) and Mg(NO3)2¡¤6H2O (0.25mmol, 64mg) were added and charged with Nitrogen (3 cycles). Anhydrous CH3CN (1mL) was then added. After heating in the oil bath at 100C for 6h (monitored by TLC), 5mL ethylacetate was added to dilute the reaction solution. The solution was filtrated, and the solvent was distilled under vacuum. The crude product was purified by silica gel column chromatography to give the desired product 3 using ethylacetate/petroleum ether (1:5 to 2:1) as eluant.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Diethylamino)-4-methyl-2H-chromen-2-one, and friends who are interested can also refer to it.

Reference:
Article; Yuan, Jin-Wei; Li, Yuan-Zhe; Yang, Liang-Ru; Mai, Wen-Peng; Mao, Pu; Xiao, Yong-Mei; Qu, Ling-Bo; Tetrahedron; vol. 71; 42; (2015); p. 8178 – 8186;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 91-44-1 as follows. Formula: C14H17NO2

To a 25 mL reaction tube, add Na2CO3 (63.6 mg, 0.60 mmol), 69.4 mg (0.30 mmol, 1 equivalent) of compound C-2,After replacing with argon three times, 1 mL of acetone (Acetone) + 1 mL of N, N-methylformamide (DMF) was added.After injecting 155 muL (0.90 mmol) of compound E-2 and stirring for 24 hours under blue light irradiation, compound H-4 was obtained with a yield of 82%.

According to the analysis of related databases, 91-44-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zunyi Medical University; He Chunyang; Mao Ting; Zhao Liang; Li Xiaofei; (13 pag.)CN110642831; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 91-44-1, A common heterocyclic compound, 91-44-1, name is 7-(Diethylamino)-4-methyl-2H-chromen-2-one, molecular formula is C14H17NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 25 mL reaction tube, add Na2CO3 (63.6 mg, 0.60 mmol), 69.4 mg (0.30 mmol, 1 equivalent) of compound C-2,After replacing with argon three times, 1 mL of acetone (Acetone) + 1 mL of N, N-methylformamide (DMF) was added.After injecting 132 muL (0.90 mmol) of compound E-1 and stirring under blue light for 24 hours, compound H-2 was obtained with a yield of 95%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zunyi Medical University; He Chunyang; Mao Ting; Zhao Liang; Li Xiaofei; (13 pag.)CN110642831; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics