Synthetic Route of 90841-55-7, A common heterocyclic compound, 90841-55-7, name is Benzyl 3-bromopropanoate, molecular formula is C10H11BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1,4, 7, 10-tetraazacyclododecane-l, 7-bis(t-butyl acetate), D02A tBu ester (leq., Macrcyclics) was dissolved in CH3CN (5ml) and benzyl 3-bromopropanoate was added in the presence of Et3N (2.1ml, 12mmol) at temp.0C. Reaction was slowly warmed up to room temp, and left stirring for 24h. After evaporation of the solvent under vacuum, product was purified by flash chromatography using 60N silica gel. Deprotection of benzyl ester groups was completed by catalytic hydrogenation under high pressure in the presence of Pd/C during 24h.
The synthetic route of 90841-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RADIOMEDIX INC.; TWOROWSKA, Izabela; SIMS-MOURTADA, Jennifer; DELPASSAND, Ebrahim, S.; WO2012/177701; (2012); A2;,
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