Category: 898787-14-9

Synthesis of chiral tertiary trifluoromethyl alcohols by asymmetric nitroaldol reaction with a Cu(II)-bisoxazolidine catalyst was written by Xu, Hanhui;Wolf, Christian. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2010.Electric Literature of C11H9F3O3 The following contents are mentioned in the article:

A highly enantioselective and diastereoselective copper(II)-bisoxazolidine catalyzed nitroaldol reaction with aliphatic and aromatic trifluoromethyl ketones is described. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Electric Literature of C11H9F3O3).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C11H9F3O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New Radical Borylation Pathways for Organoboron Synthesis Enabled by Photoredox Catalysis was written by Qi, Jing;Zhang, Feng-Lian;Jin, Ji-Kang;Zhao, Qiang;Li, Bin;Liu, Lin-Xuan;Wang, Yi-Feng. And the article was included in Angewandte Chemie, International Edition in 2020.HPLC of Formula: 898787-14-9 The following contents are mentioned in the article:

Radical borylation using N-heterocyclic carbene (NHC)-BH₃ complexes as boryl radical precursors has emerged as an important synthetic tool for organoboron assembly. However, the majority of reported methods are limited to reaction modes involving carbo- and/or hydroboration of specific alkenes and alkynes. Moreover, the generation of NHC-boryl radicals relies principally on hydrogen atom abstraction with the aid of radical initiators. A distinct radical generation method is reported, as well as the reaction pathways of NHC-boryl radicals enabled by photoredox catalysis. NHC-boryl radicals are generated via a single-electron oxidation and subsequently undergo cross-coupling with the in-situ-generated radical anions to yield gem-difluoroallylboronates. A photoredox-catalyzed radical arylboration reaction of alkenes was achieved using cyanoarenes as arylating components from which elaborated organoborons were accessed. Mechanistic studies verified the oxidative formation of NHC-boryl radicals through a single-electron-transfer pathway. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9HPLC of Formula: 898787-14-9).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 898787-14-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalytic enantioselective addition of diethylzinc to trifluoromethyl ketones. [Erratum to document cited in CA149:307341] was written by Yearick, Kimberly;Wolf, Christian. And the article was included in Organic Letters in 2008.Formula: C11H9F3O3 The following contents are mentioned in the article:

On page 3915, we overlooked previous work by Sasaki et. al. which discusses the enantioselective synthesis of tertiary alcs. via addition of diethylzinc to trifluoromethyl ketones in the presence of nitrogen-containing polydentate ligands. The following reference citation should be included: “Higashiyama, K.; Sasaki, S.; Kubo, H.; Yamauchi, T.; Ishii, A.; Kanai, M. Japanese Patent 200609692, Apr. 13, 2006.”. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Formula: C11H9F3O3).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C11H9F3O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalytic Enantioselective Addition of Diethylzinc to Trifluoromethyl Ketones was written by Yearick, Kimberly;Wolf, Christian. And the article was included in Organic Letters in 2008.Computed Properties of C11H9F3O3 The following contents are mentioned in the article:

A procedure for nucleophilic addition of diethylzinc to trifluoromethyl ketones was developed. The TMEDA-catalyzed method converts aromatic substrates to the corresponding 2-aryl-1,1,1-trifluorobutan-2-ols in up to 99% yield, and it is also applicable to less reactive aliphatic ketones if stoichiometric ligand amounts are employed. The first asym. variant producing tertiary alcs. with up to 61% ee when TBOX is used as catalyst is described. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Computed Properties of C11H9F3O3).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C11H9F3O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of Pentafluorinated β-Hydroxy Ketones was written by Zhang, Peng;Wolf, Christian. And the article was included in Journal of Organic Chemistry in 2012.Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:

The LHMDS-promoted in situ generation of difluoroenolates from readily available 1-aryl and 1-alkyl 2,2,4,4,4-pentafluorobutan-1,3-dione hydrates has been used to produce a series of pentafluorinated β-hydroxy ketones in up to 95% yield. The reaction proceeds under mild conditions, tolerates a wide range of functional groups, and is complete within 10 min. Reduction toward the corresponding 1,3-diol with DIBAL gives quant. amounts and favors the formation of the syn-isomer. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chiral Phosphoric-Acid-Catalyzed Regioselective and Enantioselective C7-Friedel-Crafts Alkylation of 4-Aminoindoles with Trifluoromethyl Ketones was written by Cai, Lu;Zhao, Yunlong;Huang, Tongkun;Meng, Shanshui;Jia, Xian;Chan, Albert S. C.;Zhao, Junling. And the article was included in Organic Letters in 2019.Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:

A highly regioselective and enantioselective C7-Friedel-Crafts alkylation of 4-aminoindoles with trifluoromethyl ketones promoted by a spirocyclic phosphoric acid was developed. This strategy was applicable to various substituted trifluoromethyl ketones and 4-aminoindole derivatives, affording the corresponding C7-functionalized indole derivatives, bearing a pharmaceutically interesting trifluoromethylated tertiary alc. scaffold, in 21%-98% yields with up to >99% enantiomeric excess (ee). This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selective Acylation of Aryl- and Heteroarylmagnesium Reagents with Esters in Continuous Flow was written by Heinz, Benjamin;Djukanovic, Dimitrije;Ganiek, Maximilian A.;Martin, Benjamin;Schenkel, Berthold;Knochel, Paul. And the article was included in Organic Letters in 2020.Formula: C11H9F3O3 The following contents are mentioned in the article:

A selective acylation of readily accessible organomagnesium reagents with com. available esters proceeds at convenient temperatures and short residence times in continuous flow. Flow conditions allow us to prevent premature collapse of the hemiacetal intermediates despite noncryogenic conditions, thus furnishing ketones in good yields. Throughout, the coordinating ability of the ester and/or Grignard was crucial for the reaction outcome. This was leveraged by the obtention of several bisaryl ketones using 2-hydroxy ester derivatives as substrates. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Formula: C11H9F3O3).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C11H9F3O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Organocatalytic Decarboxylative Cyanomethylation of Difluoromethyl and Trifluoromethyl Ketones was written by Balaraman, Kaluvu;Moskowitz, Max;Wolf, Christian. And the article was included in Advanced Synthesis & Catalysis in 2018.Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:

An efficient organocatalytic method for the synthesis of difluoromethyl and trifluoromethyl substituted β-hydroxynitriles RC(OH)(CXF₂)CH₂CN (R = Ph, cyclohexyl, furan-2-yl, etc.; X = H, F) is introduced. The decarboxylative cyanomethylation of fluorinated ketones RC(O)CXF₂ with readily available cyanoacetic acid gives a variety of tertiary alcs. in high yields and without concomitant water elimination. The reaction occurs in the presence of catalytic amounts of triethylamine, and can be upscaled and applied to chlorofluoromethyl ketones and difluoromethyl ketimines. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Efficient Access to Multifunctional Trifluoromethyl Alcohols through Base-Free Catalytic Asymmetric C-C Bond Formation with Terminal Ynamides was written by Cook, Andrea M.;Wolf, Christian. And the article was included in Angewandte Chemie, International Edition in 2016.Computed Properties of C11H9F3O3 The following contents are mentioned in the article:

The asym. addition of terminal ynamides to trifluoromethyl ketones with a readily available chiral zinc catalyst gives CF₃-substituted tertiary propargylic alcs. in up to 99 % yield and 96 % ee. The exclusion of organozinc additives and base as well as the general synthetic utility of the products are key features of this reaction. The value of the β-hydroxy-β-trifluoromethyl ynamides is exemplified by selective transformations to chiral Z- and E-enamides, an amide, and N,O-ketene acetals. The highly regioselective hydration, stereoselective reduction, and hydroacyloxylation reactions proceed with high yields and without erosion of the ee value of the parent β-hydroxy ynamides. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Computed Properties of C11H9F3O3).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C11H9F3O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Convenient, functional group-tolerant, transition metal-free synthesis of aryl and heteroaryl trifluoromethyl ketones with the use of methyl trifluoroacetate was written by Funabiki, Kazumasa;Hayakawa, Ayaka;Inuzuka, Toshiyasu. And the article was included in Organic & Biomolecular Chemistry in 2018.Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate The following contents are mentioned in the article:

A new convenient, functional group-tolerant, transition metal-free route to aryl/heteroaryl trifluoromethyl ketones such as 4-EtO₂CC₆H₄COCF₃ under mild conditions was described. The reaction of not only aryl Grignard reagents carrying reducible electrophilic functional groups, such as ester and cyano groups, but also electron-deficient nitrogen-containing heteroaryl Grignard reagents with Me trifluoroacetate gave the corresponding aryl or heteroaryl trifluoromethyl ketones in good yields. Biol. assays revealed that new heteroaryl trifluoromethyl ketones carrying 2,4-dimethoxypyrimidine and 3,5-dimethylisoxazole rings showed good antitumor activities. This study involved multiple reactions and reactants, such as Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate).

Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate (cas: 898787-14-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of Ethyl 4-(2,2,2-Trifluoroacetyl)benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics