Synthetic Route of 894796-87-3,Some common heterocyclic compound, 894796-87-3, name is Methyl 4-amino-2-(trifluoromethyl)benzoate, molecular formula is C9H8F3NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of compound 3b (20.30 g, 92.63 mmol) in 200 mL of methanol at 0 C. was slowly added dropwise a solution of liquid bromine (15.54 g, 97.26 mmol) in 200 mL of methanol. The resulting reaction solution was stirred at 0C for 1 hour and concentrated under reduced pressure to give a residue. The residue was diluted with 200 mL of ethyl acetate and 200 mL of saturated sodium bicarbonate solution, and then extracted with ethyl acetate (100 mL x 3). The combined organic phases were dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give Compound 3c (27.00 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-amino-2-(trifluoromethyl)benzoate, its application will become more common.
Reference:
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Nanjing Mingde Drug Discovery Co., Ltd.; Yao Yuanshan; Chen Bin; Chen Yuan; Li Ao; Xu Ran; Huang Zhensheng; Tian Dongdong; Li Hongwei; Yang Chengshuai; Li Jian; Chen Shuhui; (26 pag.)CN107987072; (2018); A;,
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