Category: 884497-46-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 3-amino-5-fluorobenzoate

To a solution of methyl 3-amino-S – fluorobenzoate (440mg, 2.6 mmol) in dry DMF (10 mL) was added Nail (187 mg, 7.8 mmol) portionwise, followed by addition of benzyl bromide (1.1 g, 6.5 mmol). The reaction mixture was stirred at 40 C for 1 6hr and concentrated. The resulting residue was purified by column chromatography to give the desired product. MS: 350 (M+1)

The synthetic route of 884497-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding; WO2015/10626; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 884497-46-5, Computed Properties of C8H8FNO2

Step C. Methyl 3-(dibenzylamino)-5-fluorobenzoate. To a solution of methyl 3-amino-5- fluorobenzoate (440 mg, 2.6 mmol) in dry DMF ( 10 mL) was added NaH ( 1 87 mg, 7.8 mmol) portionwise, followed by addition of benzyl bromide (1 . 1 g, 6.5 mmol). The reaction mixture was stirred at 40 C for 16 hr and concentrated. The resulting residue was purified by column chromatography to give the desired product. MS: 350 (M+ l )+.

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Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding; WO2015/10297; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H8FNO2

General procedure: To a solution of compound 11a (154 mg, 1.0 mmol) in anhydrous CH2Cl2 (10 mL) was added 3,5-dichlorobenzoyl chloride (209 mg, 1.0 mmol) and pyridine (241 mL 3.0 mmol) under ice bath. After stirring at room temperature for about 8 h, the solvent was removed in vacuum. The resulting residue was dissolved in NaOH (1 M) water solution (3 mL) and CH3OH (3 mL) and stirred for another 2 h. Then the solvent was removed under vacuum, and the residue was acidied to pH 2 or below with HCl (1 M) water solution. The solution was extracted with ethyl acetate twice and the combined organics were dried over anhydrous sodium sulfate and concentrated in vacuum. The resulting residue was puried by silica gel chromatography to give the desired compound as a white solid (234 mg, yield 85.0%)

The synthetic route of 884497-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gao, Ding-Ding; Dou, Hui-Xia; Su, Hai-Xia; Zhang, Ming-Ming; Wang, Ting; Liu, Qiu-Feng; Cai, Hai-Yan; Ding, Hai-Peng; Yang, Zhuo; Zhu, Wei-Liang; Xu, Ye-Chun; Wang, He-Yao; Li, Ying-Xia; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 44 – 59;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 884497-46-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Under argon protection,To the reactor was added 1.31 g of zinc powder (20 mmol) and 0.47 g of anhydrous lithium chloride,Join anhydrous tetrahydrofuran 10mL stirring,2.5 mol% 1,2-dibromoethane was added dropwise for 10 minutes,Then a solution of 1.81 g (10 mmol)2- (2-bromoethyl) -1,3-dioxolane in 10 mL of tetrahydrofuran,After stirring at room temperature for 3 hours,4.50g of zinc bromide (20mmol) was added with stirring,Cooled to -15 ,Then a solution of 3.22 g (12 mmol)A solution of 3-fluoro-5-methoxycarbonylbenzenediazonium tetrafluoroborate in 20 mL of tetrahydrofuran,After the addition is completed,Warmed to room temperature,1.09 g (10 mmol) of Me3SiCl,0.12 g of rhodium acetate,Heated to 87 C for 4 hours,Cool to room temperature,A small amount of dilute hydrochloric acid was added dropwise to heat to 35 C,After stirring for 2 hours,The reaction solution was extracted with ethyl acetate,The organic phase was dried and concentrated under reduced pressure.Flash column chromatography (Al2O3, ethyl acetate: petroleum ether = 1: 10),2.06 g of a white solid was obtained,Yield 93.1%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-5-fluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tsingtao Chenda Biological Technology Co., Ltd.; Chen Linghao; (8 pag.)CN106748958; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 884497-46-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound 14 (100 g, 591 mmol), compound 15 (107.68 g, 591 mmol) and dioxane (1000 ml) were added into a first reactor, then PPTS (60.82 g, 118.2 mmol) and MgSO4 (355.77 g, 2.96 mol) were added into the first reactor, then the first reactor was heated to reflux and stirred for 3 hours, cooled down to 50 C. NaBH4 (89.46 g, 2.36 mol) was added into the mixture and heated to 80 C., the first reactor was then stirred for 3 hours. After the reaction, the first reactor was cooled down to room temperature, methanol was added into the first reactor and white solid was filtered. The filtrate was concentrated and extracted by ethyl acetate, then washed with saturated NaHCO3 aqueous solution and sodium chloride aqueous solution. The organic phase was dehydrated with anhydrous sodium sulfate, filtered and concentrated to obtain crude product. The crude product was purified by column chromatography to give compound 16 (100 g, yield 53.3%). (0061)LC-MS (ESI) m/z: 318 (M+H)+.

The synthetic route of Methyl 3-amino-5-fluorobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xu, Yong; Yohi, Peter W; Xu, Michael; Cruise, Douglas; (12 pag.)US9708319; (2017); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics