Category: 878207-28-4

Reference of 878207-28-4, These common heterocyclic compound, 878207-28-4, name is Methyl 2-bromo-4,5-difluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 4-(5-(benzyloxy)-1H-indol-1-yl)-2-bromo-5-fluorobenzoate [0220] A mixture of 5-benzyloxy indole (11.2g, 0.05 mmol), methyl 2-bromo-4,5-difluoro-benzoate (12.6g, 0.05 mol) and Cs2C03 (24.4g, 0.075 mol) in DMF (150 mL) was stirred at 100 C under N2 atmosphere overnight. The mixture was cooled to room temperature and then filtrated. The filtrate was poured into 150 mL water. A gradual formation of a cream-colored precipitate was observed. Filtration gave the desired intermediate product as a cream-colored solid which is pure enough for further reaction (Yield: 17g, 74.8%). 1HNMR (500 MHz, DMSO-d6) delta: 8.02 (d, J=7 Hz, IH), 7.98 (d, J=l lHz, IH), 7.60 (s, IH), 7.48 (d, J=7.5 Hz, 2H), 7.39 (t, J=7.5 Hz, 2H), 7.32 (t, J=7 Hz, IH), 7.26 (d, J=8.5 Hz, 2H), 6.96 (d, J=8.5 Hz, IH), 6.68 (s, IH), 5.14 (s, 2H) and 3.91 (s, 3H) ppm.

Statistics shows that Methyl 2-bromo-4,5-difluorobenzoate is playing an increasingly important role. we look forward to future research findings about 878207-28-4.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; ZHANG, Yong-kang; ZHOU, Huchen; DING, Charles; PLATTNER, Jacob, J.; FREUND, Yvonne; WO2011/63293; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 878207-28-4, name is Methyl 2-bromo-4,5-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 878207-28-4, Application In Synthesis of Methyl 2-bromo-4,5-difluorobenzoate

A solution of the intermediate methyl 2-bromo-4,5-difluorobenzoate (4.4g, 17.53mmol) and benzylamine (2.066g, 2.108mL, 19.28mmol) in N,N-dimethylsulfoxide was treated with dibasic potassium phosphate (12.21g, 70.1 mmol) and heated to 75C for 18 hours in an open tube. The reaction mixture was then diluted with of ethyl acetate (20OmL), washed with of water (4x15OmL) and saturated brine before drying (sodium sulfate) and evaporation to yield the title compound (5.3g). 1H NMR (CDCI3, 400 MHz):delta 3.86 (2H, s), 4.40, (2H, d), 4.69 (1 H, br s), 6.91 (1 H, d), 7.35 (5H, m), 7.63 (1 H, d)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-bromo-4,5-difluorobenzoate, and friends who are interested can also refer to it.

Reference:
Patent; N.V. ORGANON; WO2009/138438; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 878207-28-4, name is Methyl 2-bromo-4,5-difluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of Methyl 2-bromo-4,5-difluorobenzoate

A solution of phenylmethanol (4.32 g, 0.04 mol) in dry THF (250 mL) is added NaH (1.60 g, 0.04 mol, 60% in oil). The reaction mixture is stirred at 80 C for 2 h. Then the mixture is cooled and 2-bromo-4,5-difluorobenzoic acid methyl ester (10.0 g, 0.04 mol) is added at 0C. The reaction mixture wad stirred at 0C overnight. The solution is quenched with water (50 mL) and extracted with Et20 (60 mLx2). The combined organic layers are washed with saturated NaCl solution, dried over Na2S04 and concentrated under vacuum. The residue is purified by column chromatography on silica gel to give the desired product (9.00 g, 66 %).

The synthetic route of 878207-28-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; ANACOR PHARMACEUTICALS INC.; AKAMA, Tsutomu; JARNAGIN, Kurt; PLATTNER, Jacob J.; PULLEY, Shon Roland; WHITE, William Hunter; ZHANG, Yong-Kang; ZHOU, Yasheen; WO2014/149793; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics