Category: 87808-49-9

Application of 87808-49-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of methyl 2-bromo-4-methylbenzoate (50.0 g, 218 mmol) in perchloromethane (500 mL) was added 2,2′-(diazene-l,2-diyl)bis(2-methylpropanenitrile) (3.58 g, 21.8 mmol) and l-bromopyrrolidine-2,5-dione (42.7 g, 240 mmol). The mixture was stirred at 70 C for 12 hrs. On completion, the reaction mixture was cooled to it and filtered. The filtrate was concentrated under reduced pressure to afford the title compound which was used into the next step without further purification.

The chemical industry reduces the impact on the environment during synthesis Methyl 2-bromo-4-methylbenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (358 pag.)WO2017/156165; (2017); A1;,
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Ester – an overview | ScienceDirect Topics

Reference of 87808-49-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1: Preparation of 2-(2-bromo-4-methylphenyl)propan-2-ol To a solution of methyl 2-bromo-4-methylbenzoate (4 g, 18 mmol) cooled at 0 C. was added methylmagnesium bromide (17.5 ml, 52.6 mmol) dropwise. The mixture was allowed to warm to rt and stirred overnight. Then it was quenched with aq. NH4Cl and extracted with ethyl acetate. The organic layer was dried over Na2SO4 and concentrated to provide the product (3.5 g, yield 85%). TLC analysis (silica gel plate, EA_PE=10%): Rf=0.5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromo-4-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; AKAMA, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen; US2013/131017; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 87808-49-9,Some common heterocyclic compound, 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) Compound 2 (4.0 g), Compound 3(3.52 g),[1,1′-bis (diphenylphosphino) ferrocene] palladium (II)Dichloromethane adduct (1.43 g)And potassium carbonate (7.24 g)Of N, N-dimethylformamide (80 mL)Under a nitrogen atmosphere,And the mixture was stirred at 80 C. for 6 hours.To the reaction mixture was added diethyl ether (200 mL)And the mixture was stirred, and insoluble matter was removed by filtration.Water and ethyl acetate were added to the filtrate, followed by stirring,And extracted with ethyl acetate.The obtained organic layer was washed with water and saturated brine,Dried and concentrated under reduced pressure.The residue was purified by silica gel column chromatography (hexane: ethyl acetate = 95: 5 to 80:20) to obtain Compound 4 (2.78 g) As a pale yellow viscous substance.

The synthetic route of 87808-49-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsubishi Tanabe Pharma; Sato, Atsushi; Imashiro, Ritsuo; Tuzisima Tosinori, Shuichi; Tanimoto, Koichi; Yamamoto, Yasuo Wang; Nakane, Tetsuya; Erikawa, Chihiro; (123 pag.)JP2018/199673; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87808-49-9, HPLC of Formula: C9H9BrO2

Methyl 2-bromo-4-methylbenzoate (0.0573 g, 0.25 mmol), alpha-methylstyrene (0.065 mL, 0.50 mmol), palladium acetate (0.0056 g, 0.025 mmol),Tris(4-trifluoromethylphenyl)phosphine (0.0233 g, 0.05 mmol), silver carbonate (0.1379 g, 0.5 mmol), p-toluenesulfonic acid monohydrate (0.0048 g, 0.025 mmol), 1,1,1,3 3,3-Hexafluoro-2-propanol (0.5 mL), o-xylene (0.5 mL), stirred uniformly in a clean and dry closed reaction tube, and then heated to 130 C for 12 hours.After completion of the reaction, the reaction tube was cooled to room temperature, and the reaction system was diluted with 30 mL of ethyl acetate and transferred to a 100 mL separatory funnel. 20 mL of a saturated aqueous solution of ammonium chloride was added thereto, shaken, and allowed to stand to remove the aqueous phase of the lower layer. After that, 20 mL of saturated brine was added thereto, and the mixture was shaken, and the mixture was allowed to stand. The lower aqueous layer was removed, the organic phase was dried over anhydrous sodium sulfate, and the solvent was evaporated. =20:1-10:1, v/v) Separate and purify, remove the solvent by rotary distillation, and drain the oil to obtain a colorless oil.The target product was 56.6 mg, yield 90%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Shanxi University; Wen Zhenkang; Ge Xiaomin; Liu Yufang; Chao Jianbin; (16 pag.)CN108774206; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 87808-49-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(2) A suspension of the Compound 2 (4.0 g), the Compound 3 (3.52 g), [1,1?-bis(diphenylphosphino) ferrocene]palladium(II) dichloromethane adduct (1.43 g), and potassium carbonate (7.24 g) in N,N-dimethylformamide (80 mE) was stirred at 80 C. under a nitrogen atmosphere for 6 hours. To the reaction mixture was added diethyl ether (200 mE), and the resulting mixture was stirred, and then the resulting insoluble matters were removed by filtration. To the resulting filtrate were added water and ethyl acetate, and the resulting mixture was stirred, and then extracted with ethyl acetate. The resulting organic layers were washed with water and saturated brine, then dried, and concentrated under reduced pressure. The resulting residues were purified by silica gel column chromatography (hexane:ethyl acetate=95:5 to 80:20) to give the Compound 4 (2.78 g) as a pale yellow viscous material. MS (APCI): mlz 191 [M+H](3) To

The synthetic route of Methyl 2-bromo-4-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; SATO, Atsushi; IMASHIRO, Ritsuo; TSUJISHIMA, Hidekazu; TANIMOTO, Kouichi; YAMAMOTO, Yasuo; NAKANE, Tetsu; TOSHIKAWA, Chihiro; (118 pag.)US2018/258076; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 87808-49-9, The chemical industry reduces the impact on the environment during synthesis 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, I believe this compound will play a more active role in future production and life.

NBS (8.53 g, 48 mmol) was added to a solution of methyl 2-bromo-4- methylbenzoate (10.4 g, 45.6 mmol) in CCl4 (400 ml), followed by benzyol peroxide (441 mg, 1.82 mmol). The reaction mixture was then heated to reflux and after 2 h, the reaction mix became colorless. The mixture was allowed to cool to room temperature and before it was filtered. The filtrate was concentrated to give 12 g of crude material which was purified by column chromatography (440 g silica gel 60, 230-400 mesh, 10 then 20 % CH2Cl2/hexane) to give methyl 2-bromo-4-(bromomethyl)benzoate (5.07 g, 36 %) as a white solid. MS (m/z) 307.3(M+H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromo-4-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.; WO2008/124575; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 87808-49-9,Some common heterocyclic compound, 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Preparation of 3-(2-bromo-4-methylphenyl)pentan-3-ol To a solution of methyl 2-bromo-4-methylbenzoate (10 g, 43.7 mmol) in THF (10 mL) was added dropwise EtMgBr (88 mL, 262 mmol) at 0 C. under nitrogen and then stirred at rt for 12 h. The reaction mixture was quenched with NH4Cl-saturated water and extracted with EA. The combined organic layer was washed with NaHCO3 solution and brine, dried over Na2SO4. The solution was concentrated and the residue was purified by column chromatography over silica gel eluted with PE-EA (10:1?2:1) to provide 3-(2-bromo-4-methylphenyl)pentan-3-ol (8.09 g; yield 71.2%) as a white solid. 1H NMR (400 MHz, CDCl3): delta 7.67 (d, 1H), 7.52 (s, 1H), 7.23 (d, 1H), 2.35 (s, 3H), 1.83 (m, 4H), 0.77 (t, 6H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-bromo-4-methylbenzoate, its application will become more common.

Reference:
Patent; Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; AKAMA, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen; US2013/131017; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-bromo-4-methylbenzoate

[0202] A mixture of the above product (0.600 g, 1.57 mmol), methyl 2-bromo-4-methylbenzoate (0.395 g, 1.72 mmol), potassium carbonate (0.541 g, 3.92 mmol), triphenylphosphine (0.016 g, 0.06 mmol), and palladium acetate (3.5 mg, 0.01 mmol) in 7 mL of THF and 0.2 mL of water was heated in a sealed flask at 100 C. overnight. The mixture was then cooled and partitioned between ethyl acetate and water. The organic extract was washed with brine, dried over Na2SO4, filtered and concentrated under vacuum. The residue was subjected to silica gel chromatography eluted with 0-10% ethyl acetate and hexane to provide methyl 5-methyl-4′-{(1R)-1-[(4-methyl-3-nitropyridin-2-yl)amino]ethyl}-1,1′-biphenyl-2-carboxylate that gave a proton NMR spectrum consistent with theory and a mass ion (ES+) of 406.2 for M+H+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Kuduk, Scott D.; Bock, Mark G.; Feng, Dong-Mei; Wai, Jenny Miu-Chun; US2004/34064; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 87808-49-9,Some common heterocyclic compound, 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-Bromo-4-methoxycarbonylbenzoic acid[0095] 2-bromo-4-methylbenzoic acid methyl ester (10.00 g, 42.8 mmol), tetrabutyl ammonium bromide (345 mg, 0.86 mmol), ruthenium chloride trihydrate (86 mg, 0.43 mmol), dichloroethane (14 mL) and sodium hypochlorite 10% (115 mL) were mixed. The pH at the aqueous phase was adjusted to 9.0 by addition of 20% v/v H2SO4. The biphasic mixture was stirred for 2.5 hours, and meanwhile, NaOH 20% v/v was added to keep the pH at 9. The phases were separated and the aqueous phase was washed with DCM (3 × 50 mL), acidified with 20% H2SO4 and extracted with EtOAc (3 × 50 mL). The organic layer was washed with brine (50 mL), dried over anhydrous magnesium sulfate, filtered and evaporated to dryness in vacuo to afford 3-bromo-4-methoxycarbonylbenzoic acid as a whitish solid (2.33 g, 21% yield). 1H-NMR (400 MHz, CDCl3): 8.38 (d, J = 1.5, 1H), 8.07 (dd, J = 8.1, 1.6, 1H), 7.84 (d, J = 8.1, 1H), 3.98 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-bromo-4-methylbenzoate, its application will become more common.

Reference:
Patent; Prous Institute for Biomedical Research, S.A.; Prous, Josep R.; Serradell, Neus; Munoz, Rosa; Flores, Ramon; Garcia-Delgado, Noemi; EP2573088; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics