Application of 874649-82-8,Some common heterocyclic compound, 874649-82-8, name is Methyl 6-fluorochroman-2-carboxylate, molecular formula is C11H11FO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example4: Synthesis of 4hioro-3, 4-dihydro–2Wchromene4–carb&dehyde of Formu1using Vitride in presence of IPA:A solution of methyl (50gm, 0238 moles) in Methylene dichioride (MDC) (500m1) is prepared under nitrogen atmosphere and cooled to 48C. In another flask 100 ml Toluene is added in 86.7 gm of 70% Sodium bis(2 methoxyethoxy)aluminium dihydride (vitride) solution in toluene under nitrogen atmosphere andcooled to 05C. In this solution of vitride 12.63 ml of IPA is added slowly at 05C. This vitride PA solution is added in reaction mass in 34 hrs at 43 to 48C. After the end of addition reaction mass is stirred for 0.5 hrs and then added 22.97 ml IPA at 43 to 48C. Reaction mass then quenched with 130 ml of 15% aqueous HCI solution at 43 to 48C. 250 ml water s added. Organic layer separated at RT and Aqueous layer is washed with 250 ml MDC. Finalorganic layer containing Methyl 6tuoro34dihydro2H-chromene-2-carhaldehyde is washed wti 375 m ounned water and dried over 20 gm sodun suiphatrr HPLC purity- Formula-i 85.94%, hormuia-2-1 1.08%, NOeld 99.01%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 6-fluorochroman-2-carboxylate, its application will become more common.
Reference:
Patent; CADILA PHARMACEUTICALS LIMITED; MODI, Rajiv Indravadan; ISMAILI, Aminmahamad Nasiruddin; RAUT, Dipak Bhikanrao; MANSURI, Javedhusen Karimbhai; DESAI, Chaitanya Chhotubhai; WO2014/111903; (2014); A2;,
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