Category: 87-24-1

Reference of 87-24-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87-24-1 name is Ethyl 2-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE A 9,10-Dihydrophenanthrene-1-methanol A stirred mixture of ethyl 2-methylbenzoate (30 grams, 0.183 mole) and N-bromosuccinimide (35 grams, 0.194 mole) in carbon tetrachloride (200 ml) was irradiated with an infrared lamp and heated at reflux for 20 minutes. The reaction mixture was allowed to cool to room temperature, then filtered. The filtrate was evaporated under reduced pressure to give ethyl 2-bromomethylbenzoate as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-methylbenzoate, and friends who are interested can also refer to it.

Reference:
Patent; FMC Corporation; US4451484; (1984); A;; ; Patent; FMC Corporation; US4507317; (1985); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 87-24-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87-24-1, name is Ethyl 2-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(a) A mixture of 100 g. of ethyl o-toluate, 100 g. of N-bromosuccinimide, and 0.3 g. of benzoyl peroxide in 1 liter of carbon tetrachloride is heated under reflux for 3 hours with stirring and filtered. The filtrate is washed with 3% aqueous sodium hydroxide and then with water, dried over magnesium sulfate, and concentrated under reduced pressure to provide ethyl alpha-bromo-o-toluate as an oil.

The synthetic route of Ethyl 2-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Hoechst Corporation; US4585788; (1986); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87-24-1, name is Ethyl 2-methylbenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 2-methylbenzoate

A solution of ethyl 2-toluate (17, 41.2 g, 0.25 mole) in carbon tetrachloride (200 mL) was added dropwise to a stirring mixture of benzoyl peroxide (100 mg), carbon tetrachloride (200 mL), and NBS (44.5 g, 0.25 mole) at 0 C. The mixture was heated at reflux for 3.5 hr under nitrogen, and allowed to cool to room temperature overnight. The precipitated succinimide was removed by filtration and the filter cake was washed with carbon tetrachloride. The combined filtrates were washed successively with 2 N NaOH (100 mL), and water (2*100 mL), and the solution was dried over anhydrous MgSO4, filtered (Celite), and evaporated under vacuum to yield an oil. Drying under high vacuum overnight afforded 60.5 g (99%) of compound 18: 1H NMR of the product showed the presence of ca. 15% of unreacted 17. The mixture was used in the next step without further purification: 1H NMR (CDCl3) delta 1.43 (t, J=7 Hz, 3H, CH2 CH3), 4.41 (q, J=7 Hz, 2H, CH2CH3), 4.96 (s, 1H, CH2Br), 7.24 (m, 1H, ArH), 7.38 (m, 1H, ArH), 7.48 (m, 2H, ArH).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DarPharma, Inc.; US2007/155720; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 87-24-1,Some common heterocyclic compound, 87-24-1, name is Ethyl 2-methylbenzoate, molecular formula is C10H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 2-methylbenzoate (2.0 g, 12.2 mmol) was dissolved in 30 ml carbon tetrachloride. N-bromosuccinimide (2.17 g, 12.2 mmol) and benzoyl peroxide (80 mg, 0.33 mmol) were added and the mixture was heated at 80?C for 4 h. The mixture was allowed to cool and was stirred at room temperature overnight. The mixture was filtered and the solvent was evaporated to give 3.0 g (11.8 mmol, 97%) of the title compound as a yellow oil. Purity 96%. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.43 (t, J=7.23 Hz, 3 H), 4.42 (q, J=7.29 Hz, 2 H), 4.96 (s, 2 H), 7.38 (t, J=7.42 Hz, 1 H), 7.44 – 7.55 (m, 2 H), 7.97 (d, J=7.82 Hz, 1 H). HPLC/MS (9 min) retention time 6.30 min. LRMS: m/z 243 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2-methylbenzoate, its application will become more common.

Reference:
Patent; Almirall, S.A.; EP2457900; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 87-24-1, name is Ethyl 2-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C10H12O2

Example 1 Preparation of intermediate A: Ethyl 2-methylbenzoate (15.0 g, 91 mmol) in ethyl acetate (400 mL) was treated with N-bromosuccinimide (19.5 g, 110 mmol). The resulting solution was illuminated with a 65 W mercury-halogen lamp for 16 h, which provided enough heat to bring the solution to a gentle reflux. The reaction mixture was cooled to room temperature, and ethyl acetate and water were added (100 mL each). After separation of the organic layer, the aqueous layer was extracted with ethyl acetate (400 mL). The combined organic extracts were washed twice with water (100 mL each) and then with brine (100 mL), and then dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude product so obtained was purified by flash chromatography (ethyl acetate/hexane) to afford A as a yellow oil (21.3 g).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 87-24-1.

Reference:
Patent; Roche Palo Alto LLC; US2010/16312; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 87-24-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87-24-1 name is Ethyl 2-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 1-1 (1.97g, 12mmol, 1eq), NBS (2.35g, 13.2mmol, 1eq), AIBN (98.4mg, 0.6mmol, 0.05 eq) was dissolved in 20mL of acetonitrile, the reaction was heated at reflux overnight, with TCL plate detection reaction, after completion of the reaction, the solvent under reduced pressure to give the crude product spin dry, and separated by a silica gel column, particle size of 200-300 mesh silica gel, eluent ratio of methylene chloride / petroleum ether = 1: 1, yields 56%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-methylbenzoate, and friends who are interested can also refer to it.

Reference:
Patent; University of Jinan; Lin, Weiying; Ren, Mingguang; Deng, Beibei; (14 pag.)CN105884713; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 87-24-1, name is Ethyl 2-methylbenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87-24-1, 87-24-1

General procedure: In a glove box, add a ruthenium complex Ia (0.3 to 0.7 mg, 0.0002 to 0.001 mmol) to a 300 mL autoclave,Potassium methoxide (35-700 mg, 0.5-10 mmol), tetrahydrofuran (4-60 mL), and ester compounds (10-200 mmol).After sealing the autoclave, take it out of the glove box and fill it with 50 100atm of hydrogen.The reaction kettle was heated and stirred in an oil bath at 100 C for 10 to 336 hours.After the reaction kettle was cooled in an ice-water bath for 1.5 hours, the excess hydrogen was slowly released.The solvent was removed from the reaction solution under reduced pressure, and the residue was purified with a short silica gel column to obtain an alcohol compound. The results are shown in Table 5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Zhongke Chuangyue Pharmaceutical Co., Ltd.; Ding Kuiling; Tang Yitian; Han Zhaobin; (55 pag.)CN110357923; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics