Category: 87-13-8

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. HPLC of Formula: 87-13-8.

Dube, Phelelisiwe S.;Legoabe, Lesetja J.;Jordaan, Audrey;Jesumoroti, Omobolanle J.;Tshiwawa, Tendamudzimu;Warner, Digby F.;Beteck, Richard M. research published 《 Easily accessed nitroquinolones exhibiting potent and selective anti-tubercular activity》, the research content is summarized as follows. Nitro based DprE1 inhibitors exemplified by benzothiazinones have been reported to elicit potent anti-tubercular activity. Poor PK properties associated with benzothiazinones have inspired the discovery of alternative nitro based DprE1 inhibitors. Quinolone based antibiotics on the other hand have good PK properties. The potent anti-tubercular activity of nitro compounds and the good PK properties of the quinolones have elicited an interest in us to construct a new class of nitro containing compounds around the quinolone scaffold with the aim of identifying novel DprE1 inhibitors with potent anti-tubercular activity. Thus, we report herein the anti-tubercular activity of novel 6-nitroquinolone-3-carboxamide derivatives achieved using less than five cheap synthetic transformations. Among the 23 target compounds evaluated for anti-tubercular activity, 12 were active against Mtb- exhibiting activity in the range of <0.244-31.865 μM. Compound 25 having a mol. weight of 399 Da and ClogP value of 2.7 is the most active (MIC₉₀: <0.244 μM) in this series. The SAR analyses suggest that anti-tubercular activity was influenced by substituents at position N-1 (R₂) and C-3 (R₃) of the quinolone ring. The activity data suggest that the nature of R₃ has a stronger influence on the SAR compared to R₂; with a fluorobenzyl and chlorobenzyl moiety at R₂ being the most favored when R₃ is an aliphatic amine. Docking study confirms that compound 25 binds to the same hydrophobic pocket as does TCA1, and other nitro based DprE1 inhibitors, with its nitro group in close proximity with Cys387 residue.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., HPLC of Formula: 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Product Details of C10H16O5.

Dyachenko, I. V.;Dyachenko, V. D.;Dorovatovskii, P. V.;Khrustalev, V. N.;Nenaidenko, V. G. research published 《 New Options of Multicomponent Condensations Leading to Functional Derivatives of 2-Pyridones》, the research content is summarized as follows. Multicomponent condensations of activated olefins, functionalized CH-acids, and alkylating reagents, which open up the possibility of preparing derivatives of substituted 2-pyridones, were studied. The structure of some compounds was confirmed by X-ray diffraction anal.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Product Details of C10H16O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Computed Properties of 87-13-8.

El-Essawy, Farag A.;Alharthi, Abdulrahman I.;Alotaibi, Mshari A.;Wahba, Nancy E.;Boshta, Nader M. research published 《 Design, synthesis, and evaluation of novel 3-, 4-substituted, and 3,4-di substituted quinazoline derivatives as antimicrobial agents》, the research content is summarized as follows. A novel series of 3-, 4-substituted, and 3,4-di substituted quinazoline derivatives were prepared via various cyclized regents and most of the newly prepared compounds evaluated for their antimicrobial activities in vitro against Gram-pos., Gram-neg. bacterial strains and fungi strains. The structures of the quinazoline derivatives have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Some of the synthesized derivatives displayed a moderate antimicrobial activity in comparison with reference drugs, for example compounds 13d, 15a, 17b, 18b, 18d, 25, and 29a-c. Among the synthesized compounds, the pyrimidoqunazoline derivative 6c elicited the highest activity.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Computed Properties of 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Computed Properties of 87-13-8.

El-Hadidya, Sherihan A.;Abu-Melhab, Sraa research published 《 Some studies in sulfadiazine incorporating pyridine, pyrimidine, oxadiazole, and azo moieties endowed with pharmaceutical potency》, the research content is summarized as follows. A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2-18 and hydrozaones 19a-h which were evaluated for their in vitro cytotoxicity vs. four cancer cell lines. Compounds 3, 5, 19d and 19h were active against the tested cancer cells.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Computed Properties of 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Reference of 87-13-8.

El-Tunsi, Ashraf;Carter, Nicholas;Yeo, Song-Hee;Priest, Joshua D.;Choi, Anthony;Kobras, Carolin M.;Ndlovu, Soneni;Proietti Silvestri, Ilaria;Fenton, Andrew K.;Coldham, Iain research published 《 Kinetic Resolution by Lithiation: Highly Enantioselective Synthesis of Substituted Dihydrobenzoxazines and Tetrahydroquinoxalines》, the research content is summarized as follows. Kinetic resolution provided a highly enantioselective method to access a range of 3-aryl-3,4-dihydro-2H-1,4-benzoxazines using n-butyllithium and the chiral ligand sparteine. The enantioenrichment remained high on removing the tert-butoxycarbonyl (Boc) protecting group. The intermediate organolithium underwent opening to an enamine. The kinetic resolution was extended to give enantiomerically enriched substituted 1,2,3,4-tetrahydroquinoxalines and was applied to the synthesis of an analog of the antibiotic levofloxacin that was screened for its activity against the human pathogen Streptococcus pneumoniae.

Reference of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. HPLC of Formula: 87-13-8.

Chowdhury, Raghunath;Dubey, Akhil K.;Ghosh, Sunil K. research published 《 Organocatalyzed Diastereo- and Enantioselective Conjugate Addition of Nitroalkanes to β-Silylmethylene Malonates: Direct Access to Enantioenriched Organosilanes》, the research content is summarized as follows. Cinchona-alkaloid derived bifunctional thiourea catalyzed conjugate addition reaction of nitroalkanes to β-silylmethylene malonates is reported for direct access of densely functionalized enantioenriched organosilanes in good yields (up to 86%) with excellent stereoselectivities (up to 98:2 dr and 90% ee). Using pseudoenantiomeric catalyst, both the enantiomers of the conjugate addition products were easily accessible. Preparative scale synthesis of two conjugate addition products confirmed the practical applicability of the current methods. Also, the synthetic potential of these organosilanes was demonstrated by employing one of the products in the formal asym. synthesis of the nootropic drug (R)-oxiracetam, the synthesis of sila-analog of PAR-2 agonist AC-264613, and the synthesis of (R)-N-benzyl-4-hydroxy-pyrrolidin-2-one, intermediate for the synthesis of several pharmaceuticals.

HPLC of Formula: 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Category: esters-buliding-blocks.

Coughlin, Omar;De Bruyn, Nathan;Kilgour, David P. A.;Benjamin, Sophie L. research published 《 Crystal Structure and Hirshfeld Surface Analysis of Diethyl (6-methyl-2-pyridyl)aminoethylenemalonate》, the research content is summarized as follows. The title compound, di-Et (6-methyl-2-pyridyl)aminoethylenemalonate (1), crystallizes in the monoclinic space group P2₁/c (Number 14). The unit cell parameters are a = 10.5657(7) Å, b = 9.1784(5) Å, c = 14.5681(7) Å, β = 101.636(6)°, Z’ = 1 and Z = 4 at 150 K. The extended structure forms approx. orthogonal columns of stacked mols. All bond lengths and angles are unremarkable. No disorder, twinning or co-crystallized solvent is present in the structure. An intramol. hydrogen bond exists between the enamine nitrogen and carbonyl oxygen. Hirshfeld surface anal. reveals a short contact between a carbonyl oxygen and neighboring aryl hydrogen, as well as a carbonyl-carbonyl interaction.

Category: esters-buliding-blocks, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Safety of Diethyl 2-(ethoxymethylene)malonate.

Coulibaly, Songuigama;Cimino, Mena;Ouattara, Mahama;Lecoutey, Cedric;Buchieri, Maria V.;Alonso-Rodriguez, Noelia;Briffotaux, Julien;Mornico, Damien;Gicquel, Brigitte;Rochais, Christophe;Dallemagne, Patrick research published 《 Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis》, the research content is summarized as follows. Several phenanthrolinic analogs of quinolones I [R¹ = OH, NH₂, OEt, NHNH₂, NHPh; R² = H, Cl, Br, NO₂; R³ = H, Me, Et; R⁴ = H, NO₂] were synthesized and their antibacterial activity tested against Mycobacterium tuberculosis, other mycobacterial species and bacteria from other genera. Some of them show high activity (of the range observed for rifampicin) against M. tuberculosis replicating in vitro and in vivo (infected macrophages) conditions. These derivatives showed the same activity with all or several M. tuberculosis complex bacterial mutants resistant to fluoroquinolones (FQ). This opened the way to the construction of new drugs for the treatment of FQ resistant bacterial infections, including tuberculosis. Several compounds showed also activity against Staphylococcus aureus and probably other species. These compounds did not showed major toxicity.

Safety of Diethyl 2-(ethoxymethylene)malonate, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Computed Properties of 87-13-8.

Cramer, Emma K.;AbuSalim, Deyaa I.;Lash, Timothy D. research published 《 Oxyquinoliziniporphyrins: Introduction of a Heterocyclic Dimension to Carbaporphyrinoid Systems》, the research content is summarized as follows. Oxyquinoliziniporphyrins I (R = Et, n-Bu), novel carbaporphyrinoids that incorporate quinolizone units, were synthesized. These structures exhibit moderate diamagnetic ring currents that are greatly enhanced upon protonation. Addition of trifluoroacetic acid initially gave a monocation, but this was readily converted into a dicationic species. The aromatic character of the free base and protonated species was assessed by proton NMR, nucleus-independent chem. shift calculations, and anisotropy of induced ring current plots. Stable Ni(II) and Pd(II) complexes II (R = Et, n-Bu; M = Ni, Pd) are also reported.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Computed Properties of 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. SDS of cas: 87-13-8.

Craven, Elliott J.;Latham, Jonathan;Shepherd, Sarah A.;Khan, Imtiaz;Diaz-Rodriguez, Alba;Greaney, Michael F.;Micklefield, Jason research published 《 Programmable late-stage C-H bond functionalization enabled by integration of enzymes with chemocatalysis》, the research content is summarized as follows. Herein, programmable, regioselective C-H bond functionalization methodologies have been reported for the installation of versatile nitrile, amide and carboxylic acid moieties through integration of halogenase enzymes with palladium-catalyzed cyanation and subsequent incorporation of nitrile hydratase or nitrilase enzymes. Using two- or three-component chemobiocatalytic systems, the regioselective synthesis of complex target mols., including pharmaceuticals, was achieved in a one-pot process operable on a gram scale.

SDS of cas: 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics