Category: 87-13-8

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Category: esters-buliding-blocks.

Tiwari, Shailendra;Ahmad, Akeel;Singh, Vinod Kumar research published 《 Dihetero double Michael addition in PEG-400: synthesis of 2,3-dihydro-[2,3-c]-[1,2,4]-triazole scaffold》, the research content is summarized as follows. Potassium carbonate in poly(ethylene glycol-400) had been found to be a highly effective and efficient medium for the straight forward, convenient, one pot and green synthesis of phenyl-dihydrotriazolothiadiazoles I [R = H, 2-Cl, 4-Cl, 2,4-di-Cl, 4-NO₂; R¹ = CN, CO₂Et] through intramol. cyclo-elimination of Michael adducts formed between the reaction of 4-amino-5-substituted phenyl-3-mercapto-1,2,4-triazole with diethyl-2-(ethoxymethylene)malonate and Et 2-cyano-3-ethoxyacrylate resp. The structures of all the new compounds had been elucidated using IR, ¹H and ¹³C NMR, mass spectral data and elemental anal. The compounds I were screened for their antibacterial and antifungal activities.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Quality Control of 87-13-8.

Tsizorik, Nazar M.;Hrynyshyn, Yevhenii V.;Musiychuk, Anna R.;Bol’but, Andriy V.;Nechayev, Maxim A.;Vovk, Mikhailo V. research published 《 Synthesis of 4-heteryl-substituted derivatives of methylpyrazolo[1,5-a]pyrazine-4-carboxylates》, the research content is summarized as follows. Methylpyrazolo[1,5-a]pyrazine-4-carboxylates were synthesized by palladium-catalyzed carbonylation of 4-chloropyrazolo[1,5-a]-pyrazines at elevated pressure and converted via nitrile intermediates to the corresponding amidoximes and amidines. Cyclocondensation of the obtained amidoximes with trifluoroacetic anhydride or Et chloroformate and amidines with acetoacetate or Et ethoxymethylidenemalonate were used to synthesize new 4-(1,2,4-oxadiazolyl)- and 4-(pyrimidin-2-yl)-substituted pyrazolo[1,5-a]pyrazines.

Quality Control of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Formula: C10H16O5.

Shaik, Althaf;Angira, Deekshi;Thiruvenkatam, Vijay research published 《 Insights into supramolecular assembly formation of diethyl aryl amino methylene malonate (DAM) derivatives assisted via non-covalent interactions》, the research content is summarized as follows. The crystal structures of four derivatives of di-Et 2-(((aryl)amino)methylene)malonate (DAM) have been studied by single crystal X-ray diffraction. The mol. structures of all the four derivatives were found to be in co-planar conformation. The detailed anal. of mol. conformation in four derivatives reveals the presence of a common strong intramol. N-H···O hydrogen bonding, forming a ring of graph-set motif S¹₁ (6). The effect of chloro and nitro substitution on their relative strengths of hydrogen bonding are analyzed here. Particularly, in compound 1, addnl. intramol. hydrogen bonding between -NO₂ and N-H was observed that results in the formation of another six-membered chelate ring. On the other hand in case of compound 3, we have observed type-I Cl···Cl interaction for the first time in this class of compounds Further, Hirshfeld surface has been generated that is mapped with dnorm shape index and curvedness to summarize the weak interactions and examine the mol. shapes in all four derivatives Effect of nitro (1 and 2) and chloro (3 and 4) substitution on the C···H, N···O and C···O interaction is highlighted in mol. contour and 2D fingerprint plots.

Formula: C10H16O5, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Recommanded Product: Diethyl 2-(ethoxymethylene)malonate.

Shi, Yanhua;Zhang, Shuai;Wan, Fuxian;Sun, Changxing;Jiang, Lin research published 《 Synthesis, fungicidal activity and molecular docking study of N-[2-((substituted phenyl) amino)pyridin-3-yl]pyrimidine-4-carboxamides》, the research content is summarized as follows. To explore succinate dehydrogenase inhibitor with new structure, the excellent fungicide boscalid was chosen as a lead compound, and seventeen N-[2-((substituted phenyl)amino)pyridin-3-yl]-4-methyl-2-(methylthio)pyrimidine-5-carboxamides (4a∼4g) and N-[2-((substituted phenyl)amino)pyridin-3-yl]-4-methoxy-2-(methylthio)pyrimidine-5-carboxamides (4h∼4q) were designed and synthesized. The structures of target compounds were characterized by ¹H NMR, ¹³C NMR, and MALDI-TOF-MS. The in vitro bioassay showed that sixteen compounds possessed high fungicidal activity against S. sclerotiorum with more than 90% inhibitory rate at 50μg/mL, and some compounds showed moderate activity against B. cinerea at the same dose with inhibitory rate in the range of 70%∼84%. The mol. docking study revealed that four hydrogen bonds and one cation-π interaction were formed between N-[2-((3-fluoro-4-methylphenyl)amino)pyridin-3-yl]-4-methoxy-2-(methylthio)pyrimidine-5-carboxamide (4p) and succinate dehydrogenase (SDH) enzyme.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Recommanded Product: Diethyl 2-(ethoxymethylene)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Recommanded Product: Diethyl 2-(ethoxymethylene)malonate.

Shruthi, T. G.;Subramanian, Sangeetha;Eswaran, Sumesh research published 《 Design, synthesis and study of antibacterial and antitubercular activity of quinoline hydrazone hybrids》, the research content is summarized as follows. Hydrazones and quinolines possess a wide variety of biol. activities. Here with, eleven quinoline hydrazone derivatives I (R = 3-cyanophenyl, 4-fluorophenyl, 4-methoxyphenyl, 4-methylphenyl, 4-isopropylphenyl) and II (R¹ = Ph, 2,5-dimethylphenyl, cyclohexyl, 4-methoxyphenyl, etc.) have been designed, synthesized, characterized and evaluated for their antibacterial activity and antitubercular potential against Mtb WT H37Rv. Compounds I (R = 4-fluorophenyl, 4-methoxyphenyl, 4-isopropylphenyl) (III) were found to be promising compounds with an MIC value of 4μg/mL against Mtb WT H37Rv. Compounds III and II (R¹ = 4-isopropylphenyl) were also found to be active against bacterial strains including Acinetobacter baumanii, Escherichia coli and Staphylococcus aureus. Further, experiments to confirm the cytotoxicity of the active compounds and found them to be non-toxic were carried out.

Recommanded Product: Diethyl 2-(ethoxymethylene)malonate, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Application In Synthesis of 87-13-8.

Simeone, X.;Iorio, M. T.;Siebert, D. C. B.;Rehman, S.;Schnuerch, M.;Mihovilovic, M. D.;Ernst, M. research published 《 Defined concatenated α6α1β3γ2 GABA_A receptor constructs reveal dual action of pyrazoloquinolinone allosteric modulators》, the research content is summarized as follows. Pyrazoloquinolinones (PQs) have been extensively studied as modulators of GABA_A receptors with different subunit composition, exerting modulatory effects by binding at α+/β- interfaces of GABA_A receptors. PQs with a substituent in position R7 have been reported to preferentially modulate α6- subunit containing GABA_A receptors which are mostly expressed in the cerebellum but were also found in the olfactory bulb, in the cochlear nucleus, in the hippocampus and in the trigeminal sensory pathway. They are considered potentially interesting in the context of sensori-motor gating deficits, depressive-like behavior, migraine and orofacial pain. Here we explored the option to modify the lead ligands’ R7 position. In the compound series we observed two different patterns of allosteric modulation in recombinantly expressed α6β3γ2 receptors, namely monophasic and biphasic pos. modulation. In the latter case the addnl. phase occurred in the nanomolar range, while all compounds displayed robust modulation in the micromolar range. Nanomolar, near silent binding has been reported to occur at benzodiazepine binding sites, but was not investigated at the diazepam insensitive α6+/γ2- interface. To clarify the mechanism underlying the biphasic effect we tested one of the compounds in concatenated receptors. In these constructs the subunits are covalently linked, allowing to form either the α6+/γ2- interface, or the α6+/β3- interface, to study the resulting modulation. With this approach we were able to ascribe the nanomolar modulation to the α6+/γ2- interface. While not all compounds display the nanomolar phase, the strong modulation at the α6+/β3 interface proved to be tolerant for all tested R7 groups. This provides the future option to introduce e.g. isotope labeled or fluorescent moieties or substituents that enhance solubility and bioavailability.

Application In Synthesis of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. SDS of cas: 87-13-8.

Soda, Anil Kumar;Kurva, Srinivas;Singh, Kamini;Veeragoni, Dileepkumar;Misra, Sunil;Murahari, Manikanta;Madabhushi, Sridhar research published 《 Synthesis and Pharmacological Evaluation of Hexafluoro Functionalized Quinolone Derivatives as Potential Chemotherapeutic Agents》, the research content is summarized as follows. Synthesizedma series of compound I [R¹= R² = R³ = H, Et; X = H, 8-F, 5-Cl, 8-Cl] from aryl amines as novel chemotherapeutic agents. The compound I [ R¹ = Et; R² = R³= OH; X= 5-Cl] exhibited the most potent promising antimicrobial and antibiofilm activity against Gram-pos. Staphylococcus aureus MTCC96 with a min. bactericidal concentration (MBC) value of 1.8 μg/mL and an IC₅₀ value of 15.6 ± 0.04 μM. The presence of ester linkage, electron withdrawing chlorine ortho (5-Cl) to hexafluoro-2-propanol and an unsubstituted nitrogen in the quinolone scaffold enhanced the antimicrobial activity. The compounds I [R¹= R² = R³ = H, Et; X = H, 8-F, 5-Cl] was displayed a significant cytotoxicity towards cancer cells without any toxic effects towards the normal cells.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., SDS of cas: 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Safety of Diethyl 2-(ethoxymethylene)malonate.

Sosa-Gil, Concepcion;Babiano, Reyes;Cintas, Pedro;Light, Mark E.;Palacios, Juan C. research published 《 On the anomeric preference of the isothiocyanato group》, the research content is summarized as follows. This work is aimed at providing a systematic and comprehensive anal. of the anomeric effect exerted by the isothiocyanato group taking the xylopyranose ring as a scaffold because enhanced effects have been detected in that ring-bearing halogen and pseudohalogen substituents. To this end, both α- and β-anomers of tri-O-acetoxypyranosyl-D-xylose have been prepared and thoroughly characterized. The axial preference of the isothiocyanato group reflects a dominant anomeric effect, whose origin could be determined through DFT calculations with identification of the stereoelectronic interactions as revealed by Natural Bond Orbital (NBO) anal. In this way, this study expands the repertoire of groups biasing the conformation and reactivity of monosaccharides and related heterocycles.

Safety of Diethyl 2-(ethoxymethylene)malonate, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. SDS of cas: 87-13-8.

Stolpovskaya, N. V.;Kruzhilin, A. A.;Zorina, A. V.;Shikhaliev, Kh. S.;Ledeneva, I. V.;Kosheleva, E. A.;Vandyshev, D. Yu. research published 《 Synthesis of Substituted Aminopyrimidines as Novel Promising Tyrosine Kinase Inhibitors》, the research content is summarized as follows. A procedure was proposed for the synthesis of a series of substituted N-(1,3-thiazol-2-yl)-pyrimidin-2-amines and N-(pyrimidin-2-yl)thioureas by reactions of di-Et 2-(ethoxymethylidene)malonate and Et 2-(ethyoxymethylidene)-3-oxobutanoate with 1,3-thiazol-2-ylguanidines and amidinothiourea, resp. Preliminary screening revealed high inhibitory activity of Et 2-(carbamothioylamino)-4-methylpyrimidine-5-carboxylate and Et 2-(carbamothioylamino)-6-oxo-1,6-dihydropyrimidine-5-carbox-ylate toward several protein kinases.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., SDS of cas: 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Safety of Diethyl 2-(ethoxymethylene)malonate.

Su, Tong;Zhu, Jiongchang;Sun, Rongqin;Zhang, Huihui;Huang, Qiuhua;Zhang, Xiaodong;Du, Runlei;Qiu, Liqin;Cao, Rihui research published 《 Design, synthesis and biological evaluation of new quinoline derivatives as potential antitumor agents》, the research content is summarized as follows. A series of new quinoline derivatives I [R = 3-F, 3-Br, 3,4-di-Cl, etc.; R¹ = Cl, EtO, OCH₂Ph, etc.] was designed, synthesized and evaluated for their antiproliferative activity. The results demonstrated that compounds I [R = 3-F, 3-MeO, 3-NO₂; R¹ = O(CH₂)₇CH₃, OCH₂Ph, O(CH₂)₃Ph, 4-FC₆H₄CH₂O] exhibited potent antiproliferative activity with IC₅₀ value of lower than 10 μM against seven human tumor cell lines and compound I [R = 3-MeO; R¹ = O(CH₂)₃Ph] was found to be the most potent antiproliferative agent against HCT-116, RKO, A2780 and Hela cell lines with an IC₅₀ value of 2.56, 3.67, 3.46 and 2.71 μM, resp. The antitumor efficacy of the representative compound I [R = 3-MeO; R¹ = O(CH₂)₃Ph] in mice was also evaluated, and the results showed that compound I [R = 3-MeO; R¹ = O(CH₂)₃Ph] effectively inhibited tumor growth and decreased tumor weight in animal models. Further investigation on mechanism of action indicated that compound I [R = 3-MeO; R¹ = O(CH₂)₃Ph] could inhibit colorectal cancer growth through ATG5-depenent autophagy pathway.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Safety of Diethyl 2-(ethoxymethylene)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics