Category: 87-13-8

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Formula: C10H16O5.

Watkins, Sydney M.;Ghose, Debarati;Blain, Joy M.;Grote, Dakota L.;Luan, Chi-Hao;Clare, Michael;Meganathan, R.;Horn, James R.;Hagen, Timothy J. research published 《 Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase》, the research content is summarized as follows. Enzymes in the methylerythritol phosphate pathway make attractive targets for antibacterial activity due to their importance in isoprenoid biosynthesis and the absence of the pathway in mammals. The fifth enzyme in the pathway, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF), contains a catalytically important zinc ion in the active site. A series of de novo designed compounds containing a zinc binding group was synthesized and evaluated for antibacterial activity and interaction with IspF from Burkholderia pseudomallei, the causative agent of Whitmore’s disease. The series demonstrated antibacterial activity as well as protein stabilization in fluorescence-based thermal shift assays. Finally, the binding of one compound to Burkholderia pseudomallei IspF was evaluated through group epitope mapping by saturation transfer difference NMR.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Formula: C10H16O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Product Details of C10H16O5.

Wellaway, Christopher R.;Bamborough, Paul;Bernard, Sharon G.;Chung, Chun-wa;Craggs, Peter D.;Cutler, Leanne;Demont, Emmanuel H.;Evans, John P.;Gordon, Laurie;Karamshi, Bhumika;Lewis, Antonia J.;Lindon, Matthew J.;Mitchell, Darren J.;Rioja, Inmaculada;Soden, Peter E.;Taylor, Simon;Watson, Robert J.;Willis, Rob;Woolven, James M.;Wyspianska, Beata S.;Kerr, William J.;Prinjha, Rab K. research published 《 Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype》, the research content is summarized as follows. The bromodomain and extraterminal domain (BET) family of epigenetic regulators comprises four proteins (BRD2, BRD3, BRD4, BRDT), each containing tandem bromodomains. To date, small mol. inhibitors of these proteins typically bind all eight bromodomains of the family with similar affinity, resulting in a diverse range of biol. effects. To enable further understanding of the broad phenotype characteristic of pan-BET inhibition, the development of inhibitors selective for individual, or sets of, bromodomains within the family is required. In this regard, we report the discovery of a potent probe mol. possessing up to 150-fold selectivity for the N-terminal bromodomains (BD1s) over the C-terminal bromodomains (BD2s) of the BETs. Guided by structural information, a specific amino acid difference between BD1 and BD2 domains was targeted for selective interaction with chem. functionality appended to the previously developed I-BET151 scaffold. Data presented herein demonstrate that selective inhibition of BD1 domains is sufficient to drive anti-inflammatory and antiproliferative effects.

Product Details of C10H16O5, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. HPLC of Formula: 87-13-8.

Wernik, Michaela;Hartmann, Peter E.;Sipos, Gellert;Darvas, Ferenc;Boese, A. Daniel;Dallinger, Doris;Kappe, C. Oliver research published 《 On the Regioselectivity of the Gould-Jacobs Reaction: Gas-Phase Versus Solution-Phase Thermolysis》, the research content is summarized as follows. A detailed investigation of the regioselectivity in the thermal cyclization of (pyridyl)aminomethylenemalonates both in the gas- and solution phase is presented. Flash vacuum pyrolysis (FVP) as a gas-phase thermolysis technique is used to study the Gould-Jacobs reaction at temperatures between 450-650°C, while different solution-phase heating techniques (reflux, microwave, and continuous flow) were employed at 260-350°C. Depending on the position of the substituent in the pyridine moiety and the applied thermolysis technique, the regioselectivity of the cyclization can be controlled either in favor of the kinetic (pyridopyrimidinone) or the thermodn. (naphthyridinone) product. Under FVP conditions, 6-substituted pyridopyrimidinones were obtained in high regioselectivity, which was not demonstrated before under standard Gould-Jacobs reaction conditions. DFT calculations have been addnl. performed to provide further insights into the mechanistic pathways of this specific Gould-Jacobs reaction.

HPLC of Formula: 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Safety of Diethyl 2-(ethoxymethylene)malonate.

Umar, Tarana;Shalini, Shruti;Raza, Kausar Md;Gusain, Siddharth;Kumar, Jitendra;Seth, Prerna;Tiwari, Manisha;Hoda, Nasimul research published 《 A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer’s disease》, the research content is summarized as follows. 2-(Piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides I [R = piperidin-1-yl, 4-methylpiperazin-1-yl, Et 4-((4-yl)piperazin-1-yl)quinoline-3-carboxylate, etc.] were described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid β aggregation inhibitors. Formation of synthesized compounds I was justified via ¹H NMR, ¹³C NMR, mass spectra and single crystal X-Ray diffraction study. All compounds were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activity, inhibition of self-mediated Aβ aggregation and Cu(II)-mediated Aβ aggregation. Also, docking study was carried out in concordance with in vitro results. The most potent mol. amongst the derivatives exhibited excellent anti-AChE activity (IC₅₀ = 4.8 nM). Kinetic study of I [R = 2-((4-yl)piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide] suggested it to be a mixed type inhibitor. In vitro study revealed that all the compounds were capable of inhibiting self-induced β-amyloid (Aβ) aggregation with the highest inhibition percentage to be 81.65%. Potency of I [R = Et 4-((4-yl)piperazin-1-yl)quinoline-3-carboxylate, 2-((4-yl)piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide] to inhibit self-induced Aβ1-42 aggregation was ascertained by TEM anal. Compounds were also evaluated for their Aβ disaggregation, antioxidation, metal-chelation activity.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Safety of Diethyl 2-(ethoxymethylene)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Synthetic Route of 87-13-8.

Veits, Gesine K.;Henderson, Christina S.;Vogelaar, Abigail;Eron, Scott J.;Lee, Linda;Hart, Ashley;Deibler, Richard W.;Baddour, Joelle;Elam, W. Austin;Agafonov, Roman V.;Freda, Jessica;Chaturvedi, Prasoon;Ladd, Brendon;Carlson, Mark W.;Vora, Harit U.;Scott, Thomas G.;Tieu, Trang;Jain, Arushi;Chen, Chi-Li;Kibbler, Emily S.;Pop, Marius S.;He, Minsheng;Kern, Gunther;Maple, Hannah J.;Marsh, Graham P.;Norley, Mark C.;Oakes, Catherine S.;Henderson, James A.;Sowa, Mathew E.;Phillips, Andrew J.;Proia, David A.;Park, Eunice S.;Patel, Joe Sahil;Fisher, Stewart L.;Nasveschuk, Christopher G.;Zeid, Rhamy research published 《 Development of an AchillesTAG degradation system and its application to control CAR-T activity》, the research content is summarized as follows. In addition to the therapeutic applicability of targeted protein degradation (TPD), the modality also harbors unique properties that enable the development of innovative chem. biol. tools to interrogate complex biol. TPD offers an all-chem. strategy capable of the potent, durable, selective, reversible, and time-resolved control of the levels of a given target protein in both in vitro and in vivo contexts. These properties are particularly well-suited for enabling the precise perturbation of a given gene to understand its biol., identify dependencies/vulnerabilities in disease contexts, and as a strategy to control gene therapies. To leverage these elegant properties, we developed the AchillesTag (aTAG) degradation system to serve as a tool in target identification and validation efforts. The aTAG degradation system provides a novel degradation tag based on the MTH1 protein paired with three fully validated bifunctional degraders with both in vitro and in vivo applicability. We catalog the development of the aTAG system from selection and validation of the novel MTH1 aTAG, alongside a comprehensive SAR campaign to identify high performing tool degraders. To demonstrate the utility of the aTAG system to dissect a complex biol. system, we apply the technol. to the control of Chimeric Antigen Receptor (CAR) activity. Using aTAG, we demonstrate the ability to potently and selectively control CAR protein levels, resulting in the exquisite rheostat control of CAR mediated T-cell activity. Furthermore, we showcase the in vivo application of the system via degradation of the aTAG-fused CAR protein in a human xenograft model. The aTAG degradation system provides a complete chem. biol. tool to aid foundational target validation efforts that inspire drug discovery campaigns towards therapeutic applicability.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Synthetic Route of 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Computed Properties of 87-13-8.

Venepally, Vijayendar;Sirisha, K.;Kumar, C. Ganesh;Jala, Ram Chandra Reddy research published 《 Synthesis and antimicrobial evaluation of novel alkylated piperazine-based fluoroquinolone carboxylate derivatives》, the research content is summarized as follows. In the present study, a series of Et 1-ethyl-6-fluoro-7-(4-alkylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate derivatives I (R = hexyl, heptyl, nonyl, etc.) were synthesized and evaluated for their biol. activities. Based on the antimicrobial activity studies, hexyl analog I (R = hexyl) exhibits potent antimicrobial activity against Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 121, Micrococcus luteus MTCC 2470 (MIC value 1.9μg/mL). With respect to other synthesized compounds and reference drug ciprofloxacin, compound I (R = heptyl) and compound I (R = nonyl) show significant activity with MIC value 3.9μg/mL. In the case of antifungal screening, I (R = hexyl, heptyl and nonyl) show significant antifungal activity against Candida albicans MTCC 3017 with MIC value ranged from 3.9 to 7.8μg/mL. Compounds I (R = hexyl) exhibits potent min. bactericidal concentration activity with MIC value 3.9μg/mL against the tested strains.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Computed Properties of 87-13-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Synthetic Route of 87-13-8.

Venkatesan, Perumal;Thamotharan, Subbiah;Percino, M. Judith;Ilangovan, Andivelu research published 《 Crystal Packing Modulation of the Strength of Resonance-Assisted Hydrogen Bonds and the Role of Resonance-Assisted Pseudoring Stacking in Geminal Amido Esters: Study Based on Crystallography and Theoretical Calculations》, the research content is summarized as follows. A detailed exptl. and theor. study of substituted geminal amido esters (Et (2E)-3-(arylamino)-2-(arylcarbamoyl)prop-2-enoate, AME-1-8) leading to the identification of a unique angularly fused pseudotricyclic (S(6),S(6),S(6)) ring system stabilized by an intramol. resonance-assisted H bond (RAHB) and a non-RAHB are presented in addition to weak intermol. interactions. An anal. of x-ray and theor. models reveals that the strength of the intramol. RAHB (N1-H1_N···O1) varies in a wide range (6.9-11.4 kcal mol^-1) due to crystal-packing constraints arising from different aromatic ring substitutions. The effect is less significant and the strength differs only in a narrow range (8.2-9.9 kcal mol^-1) in the case of non-RAHB. The downfield shift (δ ≈ 12.3) observed for the N-H_aniline signal in ¹H NMR spectra of AME-1-8 is due to the presence of intramol. RAHB. A PIXEL energy anal. suggests that the mol. dimer formed by stacking of RAHB pseudorings is strong (E_tot = -14.4 to -17.9 kcal mol^-1), and this dimer forms the basic motif in most of the reported structures. A detailed anal. of the isostructurality suggests that the basic motif exists in most of the structural combinations. The weak intermol. C-H···O, C-H···Cl, and C-H···π interactions play a vital role in the stabilization of these crystal structures, as evaluated by PIXEL and Bader′s quantum theory of atoms in mols. approach (QTAIM). A lattice energy anal. suggests that the Coulombic contribution and total lattice energies are higher in the para-substituted compounds (AME-2, AME-5, and AME-8) in comparison to the other isomeric compounds The crystal packing of these compounds is analyzed from the energy frameworks. Most of the crystals show similar 3D topols., suggesting that these compounds may have similar mech. behavior.

Synthetic Route of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Application of C10H16O5.

Venkatesan, Perumal;Thamotharan, Subbiah;Percino, M. Judith;Ilangovan, Andivelu research published 《 Intramolecular resonance assisted N-H···O=C hydrogen bond and weak noncovalent interactions in two asymmetrically substituted geminal amido-esters: Crystal structures and quantum chemical exploration》, the research content is summarized as follows. Two asym. substituted geminal amido-esters, namely Et (2E)-2-[(2,5-dimethoxy phenyl)carbamoyl]-3-[(4-nitrophenyl)amino] prop-2-enoate (I) and Et (2E)-2-[(9,10-dioxo-9,10-dihydroanthracen-1-yl)carbamoyl]-3-(phenylamino) prop-2-enoate (II) were synthesized and the nature and strength of intramol. resonance assisted hydrogen bond (RAHB) and non-RAHB was studied. X-ray anal. revealed that intramol. N-H···O, and C-H···O interactions lead to the formation of angularly fused pseudo tricyclic (A-C) motif in compound I and fused pseudo pentacyclic (A-E) motif in compound II. Intramol. RAHB; non-RAHB interactions are characterized and quantified by Bader’s quantum theory of atoms-in-mols. approach (QTAIM). In both compounds, ring A was found to exhibit intramol. RAHB characteristics. Crystal structures of I and II are stabilized by weak intermol. C-H···O, C-H···π, and π···π interactions. Intermol. interaction energies for different mol. dimers in I and II have been quantified by using the PIXEL, QTAIM, and DFT methods. The pseudoring stacking interaction is observed only in compound II whereas no such stacking interactions are seen in compound I. Hirshfeld surface (HS) anal. suggested that the H···H and O···H contacts are the first and second dominant contacts in both crystal structures. The theor. charge d. anal. revealed that the C-H···O and C-H···C(π) interactions produce closed-shell characteristics. Further, the crystal packing of compounds I and II analyzed based on the energy frameworks.

Application of C10H16O5, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Safety of Diethyl 2-(ethoxymethylene)malonate.

Suryawanshi, M. R.;Dupade, D. D. research published 《 Synthesis and antibacterial activity of some compounds of 1,8- naphthyridine-3-carboxamide》, the research content is summarized as follows. Synthesis and antibacterial evaluation of ten derivatives of naphthyridine-3-carboxamides I [R = 2-Me, 4-F, 3-Cl, etc.] was discussed in this paper. Synthesis of novel 1,8-naphthyridine-3-carboxamide derivatives starting from substituted pyridine with ethoxymethylenemalonate ester by cyclo-condensation reaction afforded 1,8- naphthyridine-3-carboxylates at high temperature and at specific reaction condition. All 1, 8-naphthyridine-3-carboxylate compounds were treated with an excess of substituted anilines with mild reaction conditions. All the compounds obtained were purified by using the recrystallization method. Structure confirmation of synthesized compounds was accomplished on the basis of IR, ¹H NMR, and MS. The synthesized compounds were tested against bacterial strain, Escherichia coli (Gram-neg.) Staphylococcus aureus (Gram-pos.). Many of the compounds exhibited significant antibacterial profile.

87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Safety of Diethyl 2-(ethoxymethylene)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Quality Control of 87-13-8.

Thopate, Yogesh;Singh, Richa;Rastogi, Sumit K.;Sinha, Arun K. research published 《 Cascade Multicomponent Reaction Involving Unprecedented Gould Jacobs-Heck/Suzuki Coupling-Hydrolysis-Decarboxylation Reactions in One Pot: Rapid Synthesis of Hybrid Heterocyclic Molecules》, the research content is summarized as follows. Multicomponent one-pot five-step reactions by combining two known name reactions viz. Gould-Jacobs reaction and Heck reaction for the synthesis of stilbene/biaryl-quinolone hybrid mols. I [R = H, F; R¹ = Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.], while Gould-Jacobs reaction and Suzuki reaction for II [R² = Ph, 4-OMeC₆H₄, 4-FC₆H₄, 3-ClC₆H₄] from readily available 4-iodoanilines, (diethyl-2-(ethoxymethylene)malonate) and styrenes/aryl boronic acids was reported. The use of di-Ph ether as a reaction solvent effectively mediated not only the Gould-Jacobs reaction but surprisingly also the Heck reaction for the first time. Further, di-Ph ether also allowed easy isolation of crude product due to polar nature of the product via precipitation The developed protocol thus offered unprecedented synthesis of hybrid mols. by converging five steps (Gould-Jacobs reaction, Heck or Suzuki cross coupling, hydrolysis and decarboxylation) into one pot with simultaneous generation of C-C and C-N bonds besides cleavage of C-O and C-C bonds.

Quality Control of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics