Some common heterocyclic compound, 850449-93-3, name is Methyl 2-(5-amino-2-methylphenyl)acetate, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Methyl 2-(5-amino-2-methylphenyl)acetate
6-Chloro-4-phenylamino-pyridine-3-carbaldehyde 18 (21 mg, 0.09 mmol) is mixed with 2-(5-amino-2-methyl-phenyl)acetic acid methyl ester 7 (18 mg, 0.1 mmol) and potassium carbonate (37 mg, 0.27 mmol) in DMF (2 mL). The mixture is heated to 100 0C for 16 h. After cooling to rt and removing solvent in vacuo, the crude product is purified using flash chromatography (hexane : ethyl acetate = 1 : 1). The title compound 3-(5-amino- 2-methyl-phenyl)-7-chloro-l-phenyl-lH-[l,6]naphthyridin-2-one 19 is obtained as a pale solid. 1H NMR (400MHz, CDCl3) delta 8.53 (s, IH), 7.68 (s, IH), 7.53-7.57 (m, 2H), 7.47 -7.51 (dt IH), 7.20-7.23 (m, 2H), 6.96 (d, IH), 6.59 (dd, IH), 6.58 (s, IH), 6.52 (s, IH), 2.05 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 850449-93-3, its application will become more common.
Reference:
Patent; IRM LLC; WO2008/51757; (2008); A1;,
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