Category: 85-91-6

On April 30, 2022, Chandra, Sonam; Qureshi, Saba; Chopra, Deepti; Shukla, Saumya; Patel, Sunil Kumar; Singh, Jyoti; Ray, Ratan Singh published an article.Electric Literature of 85-91-6 The title of the article was UVR-induced phototoxicity mechanism of methyl N-methylanthranilate in human keratinocyte cell line. And the article contained the following:

Fragrances are used in almost every cosmetic product. International Fragrance Association (IFRA) is the regulatory body that controls the use of fragrances in cosmetic products. Methyl-N-methylanthranilate (DMA) is a naturally derived fragrance, commonly used in cosmetic products such as fine perfumes, skin care products, etc. But there is a lack of detailed study in terms of its phototoxic and photogenotoxicity mechanisms under UVA/sunlight exposure. In this study, we have shown that DMA photodegrades in 4 h under UVA (1.5 mW/cm2) and sunlight. DMA (0.0001%-0.0025%) significantly reduced the cell viability as demonstrated by NRU and MTT assays in a dose-dependent manner under UVA (5.4 J/cm2) and sunlight (1 h) exposure in the HaCaT cell line. It generated excessive intracellular ROS (superoxide anion radical via type-I photodynamic reaction), resulting in lysosomal destabilization and mitochondrial membrane depolarization. Photo-activated DMA caused DNA fragmentation as observed by olive tail moment. DNA double-strand breaks was demonstrated by phosphorylation of H2AX-histone protein and formation of photo-micronuclei in skin keratinocytes. Addnl., photo-activated DMA upregulated the oxidative stress marker gene hemeoxygenase-1 and apoptotic marker genes (cytochrome-C, caspase-3, caspase-9). Activated caspase-cascade pathway established that photo-activated DMA can potentially trigger apoptosis in the human skin cells. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Electric Literature of 85-91-6

The Article related to skin keratinocyte phototoxicity methyl n methylanthranilate uv a sunlight, fragrance, methyl-n-methylanthranilate, photogenotoxicity, phototoxicity, type-i photodynamic reaction and other aspects.Electric Literature of 85-91-6

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2017, Radulovic, Niko S.; Miltojevic, Ana B.; Stojanovic, Nikola M.; Randjelovic, Pavle J. published an article.Name: Methyl N-Methylanthranilate The title of the article was Distinct urinary metabolite profiles of two pharmacologically active n-methylanthranilates: three approaches to xenobiotic metabolite identification. And the article contained the following:

Two volatile alkaloids, iso-Pr N-methylanthranilate (IMA) and Me N-methylanthranilate (MMA), present in the human diet and cosmetic products, were recently demonstrated to possess important pharmacol. activities. While MMA is considered to be phototoxic, there is scarce data on the toxicity of IMA. Herein, we analyzed urinary metabolites of IMA and MMA in rats (200 mg kg-1, i.p., 7 days) by combining three different approaches: 1) preparative chromatog., 2) synthesis, and 3) SPR. The preparative approach, Sephadex LH-20 chromatog. of the extract of urine samples of IMA treated animals, in conjunction with NMR, enabled the identification of 16 different anthranilate derivatives, among which products of aromatic core hydroxylation (iso-Pr 5-hydroxy-N-methylanthranilate, iso-Pr 5-hydroxyantranilate, iso-Pr 3-hydroxyantranilate) were the major ones. The first application of the synthetic/combinatorial approach led to a successful identification of MMA metabolites, where 2-(methylamino)benzamide and N-methylanthranilic acid were the principal ones, among 14 others. Generally, MMA and IMA undergo analogous biotransformation pathways; however, MMA predominantly underwent chem. conversions of the ester group, i.e. transformation into derivatives of anthranilamide and anthranilic acid, while the major metabolic pathway of IMA was hydroxylation of the aromatic core. Addnl., pathohistol. examinations revealed no signs of liver toxicity, or other signs of toxicity. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Name: Methyl N-Methylanthranilate

The Article related to urinary metabolite isopropyl methyl n methylanthranilate, isopropyl n-methylanthranilate, metabolite identification, methyl n-methylanthranilate, rat, urinary metabolites, xenobiotic and other aspects.Name: Methyl N-Methylanthranilate

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On October 31, 2020, Zhang, Penghan; Carlin, Silvia; Lotti, Cesare; Mattivi, Fulvio; Vrhovsek, Urska published an article.Application In Synthesis of Methyl N-Methylanthranilate The title of the article was On sample preparation methods for fermented beverage VOCs profiling by GCxGC-TOFMS. And the article contained the following:

Aromas and tastes have crucial influences on the quality of fermented beverages. The determination of aromatic compounds requires global non-targeted profiling of the volatile organic compounds (VOCs) in the beverages. However, exptl. VOC profiling result depends on the chosen VOC collection method. This study aims to observe the impact of using different sample preparation techniques [dynamic headspace (DHS), vortex-assisted liquid-liquid microextraction (VALLME), multiple stir bar sorptive extraction (mSBSE), solid phase extraction (SPE), and solid phase micro-extraction (SPME)] to figure out the most suitable sample preparation protocol for profiling the VOCs from fermented beverages. Five common sample preparation methods were studied with beer, cider, red wine, and white wine samples. After the sample preparation, collected VOCs were analyzed by two-dimensional gas chromatog. coupled with time of flight mass spectrometry (GCxGC-TOFMS). GCxGC oven parameters can be optimized with the Box-Behnken surface response model and response measure on peak dispersion. Due to the unavoidable column and detector saturation during metabolomic anal., errors may happen during mass spectrum construction. Profiling results obtained with different sample preparation methods show considerable variance. Common findings occupy a small fraction of total annotated VOCs. For known fermentative aromas, best coverage can be reached by using SPME together with SPE for beer, and VALLME for wine and cider. GCxGC-TOFMS is a promising tool for non-targeted profiling on VOCs from fermented beverages. However, a proper data processing protocol is lacking for metabolomic anal. Each sample preparation method has a specific profiling spectrum on VOC profiling. The coverage of the VOC metabolome can be improved by combining complementary methods. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Application In Synthesis of Methyl N-Methylanthranilate

The Article related to fermented beverage sample preparation voc profiling gcxgc tofms, fermented beverages, sample preparation methods, two dimensional gas chromatography–mass spectrometry, voc profiling and other aspects.Application In Synthesis of Methyl N-Methylanthranilate

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Ester – an overview | ScienceDirect Topics

On July 31, 2022, Kamel, Al Khansaa A.; Hozayen, Walaa; El-kawi, Samraa H. Abd; Hashem, Khalid S. published an article.Computed Properties of 85-91-6 The title of the article was Galaxaura elongata Extract (GE) Modulates Vanadyl Sulfate-Induced Renal Damage via Regulating TGF-β/Smads and Nrf2/NF-κB Pathways. And the article contained the following:

Nephrotoxicity becomes a provoked problem as the kidneys are the target of many chemotherapies. For this reason, we aimed to study the protective effect of Galaxaura elongata extract (GE) against the vanadyl sulfate (Van) induced nephrotoxicity in rats. Forty Wistar albino rats (male) were divided into four groups (n = 10) as follows: control group: rats received 0.5% CM-cellulose (CMC). Galaxa group: rats received GE at a dose (100 mg/kg orally) daily for 6 wk. Van group: rats injected with Van at a dose (50 mg/kg i.p.) once weekly for 6 successive weeks. Galaxa+Van group: rats received GE at a dose (100 mg/kg orally) daily for 6 wk concurrently with Van at a dose (50 mg/kg i.p.) for 6 wk. Our results showed that Van significantly raised urea and creatinine serum levels as compared to the control group as well as disordered renal oxidative/antioxidant redox. Administration of GE with Van alleviated the adverse impact of Van over the kidney tissues. Furthermore, GE administration in Galaxa+ Van group downregulates angiotensin-converting enzyme (ACE1) mRNA expression, angiotensin II (Ang II) concentration, transforming growth factor β (TGF-β) mRNA expression and protein concentration and Nuclear factor κB (NF-κB) mRNA expression as compared to Van group. Also, GE administration caused a noticeable upregulation of Nrf2 and heme oxygenase-1 (HO-1) expressions with a consequent decrease of DNA fragmentation % compared to Van group. The results of the current study show that simultaneous treatment with GE can alleviate nephrotoxicity caused by Van in diabetic rats. The GE treatment of the Van treated animals restored altered renal oxidative/antioxidant redox values towards normal and lessened fibrosis. These results are consistent with these efects being caused by interactions with the TGF-B/Smads and Nrf2/NF-κB signaling pathways. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Computed Properties of 85-91-6

The Article related to galaxaura elongata vanadyl sulfate tgfbeta smad nrf renal damage, ace1, ang ii, galaxaura elongata extract, ho-1, nf-κb, nephro toxicity, nrf2, smad3, smad7, tgf-β, vanadyl sulfate and other aspects.Computed Properties of 85-91-6

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2022, Zhang, Yan; Yu, Yiping; Li, Hong; Huang, Wenge; Wang, Ping published an article.Product Details of 85-91-6 The title of the article was Effects of Citri Reticulatae Pericarpium and grapefruit juice on the pharmacokinetics of omeprazole in rats. And the article contained the following:

The effects of Citri Reticulatae Pericarpium (CRP) and grapefruit juice (GFJ) on the pharmacokinetics of omeprazole were investigated in this study. Sprague-Dawley rats were pretreated with CRP decoction or GFJ for 28 consecutive days. After a single intragastric administration of 6.0 mg/kg, the concentration of omeprazole in the plasma was determined by high-performance liquid chromatog. (HPLC), and the pharmacokinetic parameters were calculated by Kinetica software 5.0. A high-performance liquid chromatog.-quadrupole-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was established to identify the chem. components in CRP decoction and GFJ. The results showed that the AUCt-∞ was significantly increased when coadministrated with CRP. The AUC0-t and AUC0-∞ was remarkably increased; the Cl was decreased when coadministrated with GFJ. A total of 31 and 28 bioactive compounds were identified in the CRP decoction and GFJ, resp. Flavonoids and furanocoumarins, including hesperidin, hesperetin, naringenin, sinensetin, tangeretin, nobiletin, and 6′,7′-dihydroxybergamottin, were simultaneously identified in CRP decoction and GFJ. This study indicates that the increased bioavailability of omeprazole may be due to the inhibition of hepatic cytochrome P 450 enzymes, and the systemic exposure should be monitored when concomitant administration with CRP and GFJ. Citri Reticulatae Pericarpium (CRP) has been widely consumed as a daily condiment, functional food, and a traditional Chinese medicine. Omeprazole, primary metabolized by CYP450 enzymes, was usually coadministered with CRP for the treatment of gastrointestinal disease. Studies have confirmed that much fruit juices, including grapefruit juice, may affect drug metabolism enzymes. CRP and grapefruit (Citrus paradisi Macf.) belong to the genus Citrus and family Rutaceae with different species. Therefore, the pharmacokinetic interaction of CRP decoction and grapefruit juice with omeprazole is worthy of attention. The results of this study can provide basic pharmacol. data support for the safe and effective clin. use of omeprazole. It can also provide a theor. basis for the development of new functional products and daily application of CRP. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Product Details of 85-91-6

The Article related to citri reticulatae pericarpium grapefruit juice omeprazole pharmacokinetics effect, citri reticulatae pericarpium, grapefruit juice, herb-drug interaction, omeprazole, pharmacokinetics and other aspects.Product Details of 85-91-6

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2021, Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Christensen, Henrik; Kouba, Maryline; Fasmon Durjava, Mojca; Lopez-Alonso, Marta; Lopez Puente, Secundino; Marcon, Francesca; Mayo, Baltasar; Pechova, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Brantom, Paul; Chesson, Andrew; Westendorf, Johannes; Manini, Paola; Pizzo, Fabiola; Dusemund, Birgit; EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) published an article.Computed Properties of 85-91-6 The title of the article was Safety and efficacy of a feed additive consisting of expressed mandarin oil from the fruit peels of Citrus reticulata Blanco for use in all animal species ( FEFANA asbl. And the article contained the following:

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on the safety and efficacy of expressed mandarin oil from the fruit peels of Citrus reticulata Blanco, when used as a sensory additive (flavouring) in feed and water for drinking for all animal species. The FEEDAP Panel concluded that the essential oil under assessment is safe up to the maximum proposed use levels in complete feed of 15 mg/kg for poultry, 33 mg/kg for pigs, 30 mg/kg for ruminants, 40 mg/kg for horse, and 15 mg/kg for salmon and rabbit. The presence of perillaldehyde was identified as a source of potential concern. However, in target species fed citrus byproducts as part of daily feed the use of the expressed mandarin oil in feed was not expected to increase the exposure to perillaldehyde to a relevant extent (< 4%). For companion animals and ornamental fish not normally exposed to citrus byproducts, no conclusion can be drawn. The FEEDAP Panel considered that the use in water for drinking is safe provided that the total daily intake of the additive does not exceed the daily amount that is considered safe when consumed via feed. No concerns for consumer safety were identified following the use of the additive up to the maximum proposed use level in feed. The essential oil under assessment should be considered as irritant to skin, eyes and the respiratory tract, and as a skin sensitizer. The use of the additive in animal feed under the proposed conditions of use was not expected to pose a risk for the environment. Expressed mandarin oil was recognized to flavor food. Since its function in feed would be essentially the same as that in food, no further demonstration of efficacy was considered necessary. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Computed Properties of 85-91-6

The Article related to citrus fruit peel mandarin oil feed additive, citrus reticulata blanco, d‐limonene, expressed mandarin oil, flavouring compounds, perillaldehyde, polymethoxylated flavones, sensory additives and other aspects.Computed Properties of 85-91-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 15, 2019, Li, Shang-Zhen; Guan, Xiang-Ming; Gao, Zhao; Lan, Hong-Ci; Yin, Qiang; Chu, Chu; Yang, De-Po; Liu, E-Hu; Zhou, Ping published an article.Quality Control of Methyl N-Methylanthranilate The title of the article was A simple method to discriminate Guangchenpi and Chenpi by high-performance thin-layer chromatography and high-performance liquid chromatography based on analysis of dimethyl anthranilate. And the article contained the following:

Citri Reticulatae Pericarpium (CRP), the dried pericarp of Citrus reticulata Blanco, can be divided into “Guangchenpi” (GCP, the dried pericarps derived from Citrus reticulata ‘Chachi’) and “Chenpi” (CP, the dried pericarps derived from other cultivars of Citrus reticulata Blanco). To discriminate between GCP and CP, a simple and reliable high-performance thin-layer chromatog. (HPTLC) method was firstly developed to analyze the volatile compound di-Me anthranilate, and a high-performance liquid chromatog. (HPLC) method was established to simultaneously quantify di-Me anthranilate and three predominant flavonoids (hesperidin, nobiletin and tangeretin) in CRP samples. Both the HPTLC anal. and HPLC-orthogonal partial least squares discrimination anal. (OPLS-DA) indicated that GCP can be effectively distinguished from CP based on anal. of di-Me anthranilate. Our results indicated that di-Me anthranilate can be used as a marker compound for discrimination of GCP and CP. This work provided a convenient approach which might be applied for quality evaluation of CRP. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Quality Control of Methyl N-Methylanthranilate

The Article related to guangchenpi chenpi hplc hptlc dimethyl anthranilate, citri reticulatae pericarpium, dimethyl anthranilate, high-performance liquid chromatography, high-performance thin-layer chromatography and other aspects.Quality Control of Methyl N-Methylanthranilate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Dan; Wang, Ping; Wu, Hanfu; Li, Jilan published an article in 2017, the title of the article was Synthesis and antimicrobial activities of novel quinazoline-2,4-dione acetyl hydrazones.Recommanded Product: Methyl N-Methylanthranilate And the article contains the following content:

Me 2-aminobenzoate was reacted with iodomethane to get Me N-methylanthranilate. The key intermediate 2-(6-chloro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl) acetohydrazide (I) was synthesized from Me N-methylanthranilate via substitution, hydrolysis, cyclization and hydrazinolysis reactions. Then the key intermediate I was reacted with various substituted aromatic aldehydes or ketones to afford a series of quinazolin-2,4-dione acetyl hydrazone compounds II [R1 = H, R2 = OMe-2, Cl-2, Br-2, OH-2, F-2, NO2-2, F-4, Cl-4, Br-4, OH-4, NO2-4, SMe-4, OMe-3-OH-4, NO2-3, OH-2-Cl-5 OMe-4; R1 = Me, R2 = Me-4, H, OMe-4; R1 = Et, R2 = H;]. The structures of all target compounds were characterized by means of 1H NMR, 13C NMR and MS. The preliminary bioassay indicated that the as-synthesized compounds had certain antibacterial activities against the tested strains. At the same time, some of them showed better antibacterial activities than the com. drugs such as streptomycin sulfate and polyoxin B. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: Methyl N-Methylanthranilate

The Article related to quinazolinedione acetyl hydrazones preparation antimicrobial antibacterial antifungal activity, dioxodihydroquinazolinyl acetohydrazide preparation condensation aromatic aldehydes ketones and other aspects.Recommanded Product: Methyl N-Methylanthranilate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 16, 2021, Ma, Yongkai; Shi, Qingshan; He, Qianxian; Chen, Gu published an article.Recommanded Product: 85-91-6 The title of the article was Metabolomic insights into the inhibition mechanism of methyl N-methylanthranilate: A novel quorum sensing inhibitor and antibiofilm agent against Pseudomonas aeruginosa. And the article contained the following:

The quorum sensing (QS) inhibition effect of Me N-methylanthranilate (MMA) from Pericarpium Citri Reticulatae Chachiensis against foodborne pathogen Pseudomonas aeruginosa was reported for the first time. MMA effectively attenuated QS related virulence factors production and biofilm formation, while suppressed expression of a dozen of QS related genes. Untargeted LC-MS metabolomics revealed 108 significantly altered metabolites after MMA treatment. They indicated that MMA addition reduced the efficiency of TCA cycle and antioxidant systems, disturbed amino acid and nucleotide metabolism, increased unsaturated fatty acid and decreased peptidoglycan components, which might ultimately attenuate P. aeruginosa pathogenicity and restrain biofilm formation. Physiol. characterization confirmed the compromised membrane integrity and increased intracellular oxidative stress after MMA treatment. Furthermore, metabolomics data implied that MMA inhibition on QS might exert through disrupting QS autoinducer PQS biosynthesis, which was supported by mol. docking. Our data indicated that MMA could be used as a novel QS inhibitor and anti-biofilm agent to improve food safety. It also provided new insight in the possible underlying inhibition mechanism of MMA and the response of P. aeruginosa to MMA. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: 85-91-6

The Article related to pseudomonas methyl n methylanthranilate quorum sensing biofilm food safety, antibiofilm, metabolomics, methyl n-methylanthranilate, pqsa, pseudomonas aeruginosa, quorum sensing inhibitor and other aspects.Recommanded Product: 85-91-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Frost, Grant B.; Mittelstaedt, Michaela N.; Douglas, Christopher J. published an article in 2019, the title of the article was Chemoselectivity for Alkene Cleavage by Palladium-Catalyzed Intramolecular Diazo Group Transfer from Azide to Alkene.Quality Control of Methyl N-Methylanthranilate And the article contains the following content:

A palladium-catalyzed intramol. azide to alkene DGT, which granted chemoselectivity over competing aziridination. The data supported a catalytic cycloreversion mechanism distinct from other known metal-catalyzed azide/alkene reactions: nitrenoid/metalloradical and (3+2) cycloadditions Kinetics experiments revealed an unusual mechanistic profile in which the catalyst was not operative during the rate-controlling step, rather, it was active during the product-determining step. Catalytic DGT was used to synthesize N-heterocyclic quinazolinones, a medicinally relevant structural core. On the competing aziridination and subsequent ring expansion to another N-heterocyclic core structure of interest, benzodiazepinones was also reported. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Quality Control of Methyl N-Methylanthranilate

The Article related to benzyl alkenyl phenyl carbamoyl azide preparation palladium catalyst chemoselective, benzo dihydroquinazolinone preparation, alkene cleavage, azides, cycloreversion, diazo group transfer, palladium and other aspects.Quality Control of Methyl N-Methylanthranilate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics