Category: 85-91-6

On August 31, 2016, Tomiyama, Kenichi; Sakurai, Kazutoshi; Yaguchi, Yoshihiro; Kawakami, Yukihiro; Asakawa, Yoshinori published an article.Reference of Methyl N-Methylanthranilate The title of the article was Characteristic Volatile Components of Trifoliate Orange Peel (Poncirus trifoliata). And the article contained the following:

The volatile components of the peel of trifoliate orange {Poncirus trifoliata (L.) Raf.}, family Rutaceae, were investigated using SAFE technique after solvent extraction Limonene was the most abundant component in the peel aroma extract, followed by myrcene, trans-β-ocimene, indole, β-caryophyllene, (3E,6E)-α-farnesene, germacrene D, and β-phellandrene. In this study, the single sulfur- and nitrogen-containing compound, 4-methyl-5-vinylthiazole, and two macrocyclic lactones, cyclododecanolide and (7Z,10Z,13Z)-hexadecatrien-16-olide, were identified as citrus aroma components for the first time. As a result of AEDA for the polar fraction of the aroma extract, indole, Et octanoate and those macrocyclic lactones with musky notes were found to be responsible for the characteristic aroma profile of the peel of trifoliate orange. The enantiomeric distributions of the four odor-active components, linalool, β-citronellol, Et 2-methylbutanoate, and 2-methylbutanoic acid, were also determined by means of multidimensional chiral GC/MS. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Reference of Methyl N-Methylanthranilate

The Article related to poncirus trifoliata peel volatile component, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Reference of Methyl N-Methylanthranilate

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On October 28, 2020, Tokunaga, Keisuke; Sato, Mami; Kuwata, Keiko; Miura, Chizuru; Fuchida, Hirokazu; Matsunaga, Naoya; Koyanagi, Satoru; Ohdo, Shigehiro; Shindo, Naoya; Ojida, Akio published an article.Recommanded Product: Methyl N-Methylanthranilate The title of the article was Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins. And the article contained the following:

Expanding the repertoire of electrophiles with unique reactivity features would facilitate the development of covalent inhibitors with desirable reactivity profiles. We herein introduce bicyclo[1.1.0]butane (BCB) carboxylic amide as a new class of thiol-reactive electrophiles for selective and irreversible inhibition of targeted proteins. We first streamlined the synthetic routes to generate a variety of BCB amides. The strain-driven nucleophilic addition to BCB amides proceeded chemoselectively with cysteine thiols under neutral aqueous conditions, the rate of which was significantly slower than that of acrylamide. This reactivity profile of BCB amide was successfully exploited to develop covalent ligands targeting Bruton’s tyrosine kinase (BTK). By tuning BCB amide reactivity and optimizing its disposition on the ligand, we obtained a selective covalent inhibitor of BTK. The in-gel activity-based protein profiling and mass spectrometry-based chem. proteomics revealed that the selected BCB amide had a higher target selectivity for BTK in human cells than did a Michael acceptor probe. Further chem. proteomic study revealed that BTK probes bearing different classes of electrophiles exhibited distinct off-target profiles. This result suggests that incorporation of BCB amide as a cysteine-directed electrophile could expand the capability to develop covalent inhibitors with the desired proteome reactivity profile. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: Methyl N-Methylanthranilate

The Article related to bicyclobutane carboxylic amide cysteine electrophile, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Recommanded Product: Methyl N-Methylanthranilate

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On January 31, 2022, Chao, Yingxin; Tan, E-yu; Ma, Shaofeng; Chen, Baizhong; Liu, Mengshi; Wang, Kanghui; Yang, Wanling; Wei, Minyan; Zheng, Guodong published an article.SDS of cas: 85-91-6 The title of the article was Dynamic variation of the phytochemical and volatile compounds in the pericarp of Citrus reticulata ”Chachi” (Rutaceae) during 2 years of storage. And the article contained the following:

The pericarp of Citrus reticulata “Chachi” (CRCP) is used as nutritional food and traditional medicine in China, usually harvested at three periods, namely, immature (CRCP-G1), semi-mature (CRCP-G2), and fully mature (CRCP-G3). Traditionally, if the CRCP is stored for a longer period, then the quality will be better. In this study, the dynamic variation of phytochem. and volatile compounds was profiled in the same batches of CRCP during 2 years of storage. Results illustrated that most of the phytochem. compounds showed a decreasing trend during storage, i.e., total flavonoids, total phenolic acids, hesperidin, 3,5,6,7,8,3,4-heptamethoxyflavone, 5-hydroxy-6,7,8,3,4-pentamethoxyflavone, synephrine, and limonin. The ferulic acid increased significantly, whereas no significant changes were observed in the total polymethoxyflavones, nobiletin, and tangeretin after 2 years of storage. In addition, we found that the extraction yield of volatile oil decreased significantly in CRCP-G1 during storage, and the herb odors were enhanced with the increase of phenols and esters. No significant difference in the extraction yield of volatile oil of CRCP-G2 and CRCP-G3 was found after 2 years of storage, but the citrus-like notes were increased with the promoted generation of alkenes. In particular, the multivariate statistical anal. indicated that 7 volatiles showed a higher level after 1 yr of storage, whereas 11 volatiles decreased and 4 volatiles increased after 2 years of storage, resp. This study could show the early aging mechanism of CRCP harvested at different periods and provide a scientific guidance in the storage of CRCP. This study indicated a comprehensive method for rapid anal. of phytochem. and volatile compounds in pericarp of Citrus reticulata ”Chachi” (Rutaceae) (CRCP) harvested at different periods during 2 years of storage. The results obtained from this study would be valuable for revealing the early aging mechanism and sustainable storage of CRCP. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).SDS of cas: 85-91-6

The Article related to dynamic variation volatile compound pericarp citrus storage, phytochemical compounds, storage, the pericarp of citrus reticulata ‘chachi’ (crcp), volatile compounds, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.SDS of cas: 85-91-6

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On June 30, 2017, Ndayishimiye, John; Getachew, Adane Tilahun; Chun, Byung Soo published an article.Recommanded Product: 85-91-6 The title of the article was Comparison of Characteristics of Oils Extracted from a Mixture of Citrus Seeds and Peels Using Hexane and Supercritical Carbon Dioxide. And the article contained the following:

Abstract: The processing of citrus fruits into juice is one of the world’s largest processing industries. The byproducts of this industry are about 50 % of the raw processed fruit. This not only wastes a resource of potential value, but also causes disposal problems. The aim of this work was to study the characteristics of oils extracted from a mixture (MX) of citrus seeds (CS) and citrus peels (CP) using hexane and supercritical carbon dioxide (SC-CO2) so that those byproducts can be valorized effectively. The SC-CO2 extraction conditions were 45 and 60 °C, 200 and 250 bar while for hexane was 70 °C. Hexane showed significantly (P < 0.05) higher yield than SC-CO2. The chem. composition was analyzed by GC-MS and phytosterols, monoterpenes, sesquiterpenes and oxygenated monoterpenes were the main compounds of the oils. The fatty acid composition was determined by GC and linoleic acid was the major fatty acid. The oxidative stability (OS) was performed by Rancimat and the hexane extracted oils showed higher OS. The antioxidant activity was tested with DPPH and ABTS assay and SC-CO2 extracted oils showed higher activity with IC50 values of 3.86 and 4.00 mg/mL resp. for MX and CP oils. Antimicrobial activity was tested for both extracted oils against gram pos. and gram neg. bacteria with SC-CO2 extracted oils exhibiting better inhibition. From this study, we can say that the citrus byproducts can be valorized by combining CS and CP which could give the oils with potentiality to be used in many applications. Graphical Abstract: [Figure not available: see fulltext.]. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: 85-91-6

The Article related to citrus seed oil hexane supercritical carbon dioxide antimicrobial antioxidant, Food and Feed Chemistry: Packaging, Preservation, and Processing and other aspects.Recommanded Product: 85-91-6

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Zheng, Yuying; Zeng, Xuan; Peng, Wei; Wu, Zhong; Su, Weiwei published an article in 2018, the title of the article was Study on the discrimination between citri reticulatae pericarpium varieties based on HS-SPME-GC-MS combined with multivariate statistical analyses.Synthetic Route of 85-91-6 And the article contains the following content:

Citri reticulatae pericarpium (CRP), the dried pericarps of Citrus reticulata Blanco and its cultivars, has been widely used in drugs and foods in China for centuries. In this study, an accurate and feasible anal. method based on HS-SPME-GC-MS coupled with multivariate statistical analyses was developed to comprehensively compare volatile compounds of pericarps derived from Citrus reticulata “Chachi” (“Guangchenpi” in Chinese, GCP) and other cultivars of Citrus reticulata Blanco (“Chenpi” in Chinese, CP). Principal component anal., hierarchical cluster anal., and orthogonal partial least-squares-discrimination anal. were performed to extract meaningful attributes from volatile profiles based on GC-MS data. Results indicated that samples from GCP and CP could easily be differentiated, and seven potential chem. markers were screened for the quality control of CRP. This study illuminated the volatile profile in CRP, and provides a practical method for the authentication of CRP varieties. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Synthetic Route of 85-91-6

The Article related to citrus pericarpium volatile compound gas chromatog mass spectrometry, citri reticulatae pericarpium, hs-spme-gc-ms, multivariate statistical analyses, volatile compounds, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Synthetic Route of 85-91-6

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Chokchaisiri, Suwadee; Apiratikul, Nuttapon; Rukachaisirikul, Thitima published an article in 2020, the title of the article was A new ent-abietane lactone from Glycosmis pentaphylla.Formula: C9H11NO2 And the article contains the following content:

A new ent-abietane lactone, 3-oxojolkinolide A, together with 16 known compounds, helioscopinolide E, helioscopinolide A, 3-methyl-9H-carbazole, carbalexin, carbalexin B, glycaborinine, arborinine, 1H-indole-3-carbaldehyde, glycoamide A, glycoamide B, 2-(N-methyl-2-phenylacetamido)benzoic acid, 2-(methylamine)-methylbenzoate, fraxidin, scopoletin, (-)-syringaresinol and ferulic acid were isolated from Glycosmis pentaphylla. The structures of these compounds were elucidated using spectroscopic techniques such as NMR and MS. Among them, compounds -, and – were isolated from the genus Glycosmis for the first time. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Formula: C9H11NO2

The Article related to abietane lactone isolation glycosmis pentaphylla cancer, glycosmis pentaphylla, rutaceae, alkaloids, coumarins, cytotoxicity, ent-abietane lactones, lignan, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Formula: C9H11NO2

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On January 23, 2020, Wang, Lei; Fang, Kun; Cheng, Junfei; Li, Yu; Huang, Yahui; Chen, Shuqiang; Dong, Guoqiang; Wu, Shanchao; Sheng, Chunquan published an article.Name: Methyl N-Methylanthranilate The title of the article was Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer. And the article contained the following:

Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone scaffold was designed by scaffold hopping. Structure-activity relationship studies led to the discovery of compound 15j, which shows low nanomolar inhibitory activity against the HCT116 cell line. Further antitumor mechanism studies indicated that compound 15j acted by the dual inhibition of topoisomerase 1 and tubulin and induced apoptosis with G2 cell-cycle arrest. The quaternary ammonium salt of compound 15j (compound 15js) exhibited excellent in vivo antitumor activity (TGI = 66.6%) in the HCT116 xenograft model with low toxicity. Indolopyrazinoquinazolinone derivatives represent promising multitargeting antitumor leads for the development of novel antitumor agents. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Name: Methyl N-Methylanthranilate

The Article related to colon cancer antitumor agents sar topoisomerase tubulin scaffold apoptosis, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Name: Methyl N-Methylanthranilate

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Zlatkovic, Dragan; Dallinger, Doris; Kappe, C. Oliver published an article in 2020, the title of the article was A novel pathway for the thermolysis of N-nitrosoanthranilates using flash vacuum pyrolysis leading to 7-aminophthalides.Product Details of 85-91-6 And the article contains the following content:

Flash vacuum pyrolysis of Me N-methyl-N-nitrosoanthranilate leads to elimination of nitric oxide and disproportionation of the formed N-radical to 7-(methylamino)phthalide and Me N-methylanthranilate. This transformation is a convenient, solvent-free method for the preparation of 7-(methylamino)phthalides. An alternative route through pyrolysis of N-benzyl-N-Me anthranilates was also studied. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Product Details of 85-91-6

The Article related to aminophthalide preparation nitrosoanthranilate thermolysis flash vacuum pyrolysis, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Product Details of 85-91-6

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On December 15, 2020, Lu, Nan; Yan, Xiaoqing; Kobayashi, Hisayoshi; Liu, Wen; Chen, Shuang; Liang, Shipan; Zhang, Jiemei; Li, Renhong published an article.Application of 85-91-6 The title of the article was Oxygen-mediated water splitting on metal-free heterogeneous photocatalyst under visible light. And the article contained the following:

We report a visible-light-driven, photocatalytic partial water splitting process that proceeds via an oxygen-mediated, sequential single-electron transfer mechanism over heterogeneous photocatalysts. In the absence of any cocatalyst, hydrogen evolution efficiency of 78.9 and 643.0μmol h-1 g-1catalyst were achieved over a simple carbon nitride catalyst from methanol and formaldehyde solutions, resp., in 1.0 bar O2 atmosphere at room temperature On the carbon nitride catalyst, mol. O2 is photocatalytically transformed into reactive oxygen species, which acted both as an oxidant and as a homogeneous catalyst for the partial photocatalytic water splitting reaction, resulting in the two-step oxidation of methanol to formaldehyde and subsequently formic acid. DFT calculations reveal that the new oxygen mediated photocatalytic hydrogen evolution pathway proceeds with virtually zero activation energy. Further improvement in hydrogen evolution efficiency was attained by doping the carbon nitride catalyst with phosphorous and sulfur, which promoted the transport of photogenerated charge carriers. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Application of 85-91-6

The Article related to oxygen water splitting metal free heterogeneous photocatalyst visible light, Electrochemical, Radiational, and Thermal Energy Technology: Other and other aspects.Application of 85-91-6

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Bekkar, Nour El Houda; Meddah, Boumediene; Keskin, Bahadir; Sonnet, Pascal published an article in 2021, the title of the article was Oral acute toxicity, influence on the gastrointestinal microbiota and in vivo anti-salmonellosis effect of Zizyphus lotus (L.) and Ruta chalepensis (L.) essential oils.Product Details of 85-91-6 And the article contains the following content:

The aim of this study was to evaluate the chem. composition of Zizyphus lotus and Ruta chalepensis essential oils (EOs), the oral acute toxicity, influence on the gastrointestinal microbiota and the in vivo anti-salmonellosis effect. The EOs were isolated using the steam distillation process, and bioactive components were identified by gas chromatog.-mass spectrometry (GC-MS) anal. Oral acute toxicity, influence on the gastrointestinal flora composition and the anti-salmonellosis effect were elucidated using in vivo methods on exptl. animals. The GC-MS allowed us to identify 33 and 58 components in Z. lotus and R. chalepensis, resp. Di-isooctyl phthalate (89.857%) was found to be the major compound identified in Z. lotus. The main compounds in R. chalepensis were 2-undecanone (26.528%) followed by 2-nonanone (13.404%). The LD50 of EOs was found to be greater than 5000 mg/kg. Also, no neg. influence to intestinal microbiota was detected. An important decrease in S. enterica ssp arizonae cells achieving a bactericidal effect was recorded in rats treated with the EOs of both plants at a dose of 400 mg/kg. In parallel, an important significant (P < 0.05) increase in lymphocytes number was observed for all tested animals. A decrease in alk. phosphatase (ALP), amino alanine transferase (ALT) and aspartate aminotransferase (AST) levels was observed Furthermore, a reduced blood erythrocyte sedimentation rate (ESR) was recorded in treated animals. The Z. lotus and R. chalepensis act effectively as anti-salmonellosis agents, which support the use of these plants to cure gastrointestinal infections. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Product Details of 85-91-6

The Article related to zizyphus ruta essential oils gastrointestinal microbiota antisalmonellosis oral acute, Microbial, Algal, and Fungal Biochemistry: Composition and Products and other aspects.Product Details of 85-91-6

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