Category: 85-91-6

On April 30, 2019, Roell, Daniela; Roesler, Thomas W.; Hessenkemper, Wiebke; Kraft, Florian; Hauschild, Monique; Bartsch, Sophie; Abraham, Tsion E.; Houtsmuller, Adriaan B.; Matusch, Rudolf; van Royen, Martin E.; Baniahmad, Aria published an article.Category: esters-buliding-blocks The title of the article was Halogen-substituted anthranilic acid derivatives provide a novel chemical platform for androgen receptor antagonists. And the article contained the following:

Here we analyzed structure-activity relationships of a battery of 36 non-steroidal structural variants of Me anthranilate including 23 synthesized compounds We identified structural requirements that lead to more potent AR antagonists. Specific compounds inhibit the transactivation of wild-type AR as well as AR mutants that render treatment resistance to hydroxyflutamide, bicalutamide and the second-generation AR antagonist enzalutamide. This suggests a distinct mode of inhibiting the AR compared to the clin. used compounds Competition assays suggest binding of these compounds to the AR ligand binding domain and inhibit PCa cell proliferation. Moreover, active compounds induce cellular senescence despite inhibition of AR-mediated transactivation indicating a transactivation-independent AR-pathway. In line with this, fluorescence resonance after photobleaching (FRAP) – assays reveal higher mobility of the AR in the cell nuclei. Mechanistically, fluorescence resonance energy transfer (FRET) – assays indicate that the amino-carboxy (N/C)-interaction of the AR is not affected, which is in contrast to known AR-antagonists. This suggests a mechanistically novel mode of AR-antagonism. Together, these findings indicate the identification of a novel chem. platform as a new lead structure that extends the diversity of known AR antagonists and possesses a distinct mode of antagonizing AR-function. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Category: esters-buliding-blocks

The Article related to prostate cervical cancer methyl anthranilate androgen receptor antiandrogen antihormone, androgen receptor, antiandrogens, antihormone, cellular senescence, methyl anthranilate derivatives, prostate cancer and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Awadelkareem, Amir Mahgoub; Al-Shammari, Eyad; Elkhalifa, Abd Elmoneim O.; Adnan, Mohd; Siddiqui, Arif Jamal; Snoussi, Mejdi; Khan, Mohammad Idreesh; Azad, Z. R. Azaz Ahmad; Patel, Mitesh; Ashraf, Syed Amir published an article in 2022, the title of the article was Phytochemical and In Silico ADME/Tox Analysis of Eruca sativa Extract with Antioxidant, Antibacterial and Anticancer Potential against Caco-2 and HCT-116 Colorectal Carcinoma Cell Lines.HPLC of Formula: 85-91-6 And the article contains the following content:

Eruca sativa Mill. (E. sativa) leaves recently grabbed the attention of scientific communities around the world due to its potent bioactivity. Therefore, the present study investigates the metabolite profiling of the ethanolic crude extract of E. sativa leaves using high resolution-liquid chromatog.-mass spectrometry (HR-LC/MS), including antibacterial, antioxidant and anticancer potential against human colorectal carcinoma cell lines. In addition, computer-aided anal. was performed for determining the pharmacokinetic properties and toxicity prediction of the identified compounds Our results show that E. sativa contains several bioactive compounds, such as vitamins, fatty acids, alkaloids, flavonoids, terpenoids and phenols. Furthermore, the antibacterial assay of E. sativa extract showed inhibitory effects of the tested pathogenic bacterial strains. Moreover, the antioxidant activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) were found to be IC50 = 66.16 μg/mL and 76.05 μg/mL, resp. E. sativa also showed promising anticancer activity against both the colorectal cancer cells HCT-116 (IC50 = 64.91 μg/mL) and Caco-2 (IC50 = 83.98 μg/mL) in a dose/time dependent manner. The phytoconstituents identified showed promising pharmacokinetics properties, representing a valuable source for drug or nutraceutical development. These investigations will lead to the further exploration as well as development of E. sativa-based nutraceutical products. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).HPLC of Formula: 85-91-6

The Article related to gene expression eruca antioxidant antibacterial anticancer agent colorectal carcinoma, eruca sativa, bioactive compounds, colorectal cancer, erucin, isothiocyanates, jarjeer, nutraceutical, phytochemical analysis and other aspects.HPLC of Formula: 85-91-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 15, 2018, Xu, Yangyang; Cai, Hao; Cao, Gang; Duan, Yu; Pei, Ke; Tu, Sicong; Zhou, Jia; Xie, Li; Sun, Dongdong; Zhao, Jiayu; Liu, Jing; Wang, Xiaoqi; Shen, Lin published an article.Product Details of 85-91-6 The title of the article was Profiling and analysis of multiple constituents in Baizhu Shaoyao San before and after processing by stir-frying using UHPLC/Q-TOF-MS/MS coupled with multivariate statistical analysis. And the article contained the following:

Baizhu Shaoyao San (BSS) is a famous traditional Chinese medicinal formula widely used for the treatment of painful diarrhea, intestinal inflammation, and diarrhea-predominant irritable bowel syndrome. According to clin. medication, three medicinal herbs (Atractylodis Macrocephalae Rhizoma, Paeoniae Radix Alba, and Citri Reticulatae Pericarpium) included in BSS must be processed using some specific methods of stir-frying. On the basis of the classical theories of traditional Chinese medicine, the therapeutic effects of BSS would be significantly enhanced after processing. Generally, the changes of curative effects mainly result from the variations of inside chem. basis caused by the processing procedure. To find out the corresponding changes of chem. compositions in BSS after processing and to elucidate the material basis of the changed curative effects, an optimized ultra-high-performance liquid chromatog.-quadrupole/time-of-flight mass spectrometry in pos. and neg. ion modes coupled with multivariate statistical analyses were developed. As a result, a total of 186 compounds were ultimately identified in crude and processed BSS, in which 62 marker compounds with significant differences between crude and processed BSS were found by principal component anal. and t-test. Compared with crude BSS, the contents of 23 compounds were remarkably decreased and the contents of 39 compounds showed notable increase in processed BSS. The transformation mechanisms of some changed compounds were appropriately inferred from the results. Furthermore, compounds with extremely significant differences might strengthen the effects of the whole herbal formula. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Product Details of 85-91-6

The Article related to baizhu shaoyao san constituent stir frying uhplc qtof ms, baizhu shaoyao san, chemical markers, multivariate statistical analysis, traditional chinese herbal formula, traditional chinese medicine processing, uhplc/q-tof-ms/ms and other aspects.Product Details of 85-91-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Rong; Li, Zhihong; Ren, Peiling; Chen, Wenzhang; Kuang, Yuanyuan; Chen, Jiakang; Zhan, Yuexiong; Chen, Hongli; Jiang, Biao published an article in 2018, the title of the article was N-phenyl-N-aceto-vinylsulfonamides as efficient and chemoselective handles for N-terminal modification of peptides and proteins.COA of Formula: C9H11NO2 And the article contains the following content:

A number of vinylsulfonamides were synthesized and screened to identify reagents that can be used to modify octreotide under biol. pH and room temperature with improved efficiency. N-Phenyl-N-aceto-vinylsulfonamide exhibits higher reactivity and has emerged as an efficient reagent that has the ability to realize the selective modification of peptides and proteins at the N-terminus via aza-Michael addition We showed that, after conjugation of peptides and proteins with the reagent containing a bioorthogonal functional group, the derivatives could be further labeled by functionalities, including fluorescent tags, modified drugs and polyethylene glycol (PEG) polymers without the need for prior treatment. Somatostatin, lysozyme, and RNaseA were selectively modified at the N-terminus, which illustrated the application of the method. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).COA of Formula: C9H11NO2

The Article related to phenyl aceto vinyl sulfonamide synthesis handle peptide protein modification, somatostatin lysozyme rnasea aza michael addition vinylsulfonamide regioselective synthesis, lysozyme rnasea click chem azide alkyne cycloaddition fluorescein and other aspects.COA of Formula: C9H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2019, Miltojevic, Ana B.; Stojanovic, Nikola M.; Randjelovic, Pavle J.; Radulovic, Niko S. published an article.COA of Formula: C9H11NO2 The title of the article was Distribution of methyl and isopropyl N-methylanthranilates and their metabolites in organs of rats treated with these two essential-oil constituents. And the article contained the following:

Two volatile alkaloids, Me (MMA) and iso-Pr N-methylanthranilates (IMA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been proven to possess polypharmacol. properties (antinociceptive, anti-inflammatory, gastro-, hepato-, nephroprotective activities, anxiolytic and antidepressant properties, and likewise an effect on diazepam-induced sleep). In the continuation of our investigation of their urinary-metabolite profiles, we performed GC-MS analyses of the diethyl-ether extracts of selected tissues (liver, kidneys, heart, brain, lungs, quadriceps femoris muscle, and spleen) of rats i.p. treated with MMA or IMA (2 g kg-1). Organ-metabolite profiles of MMA and IMA were qual. mutually analogous (varying only in the alc. moiety of the metabolites), and generally analogous to their urinary-metabolite profiles. The principal anthranilate-related compounds in the organs of rats treated with MMA, among 12 detected, were the products of ester hydrolysis, N-methylanthranilic and anthranilic acids. In the tissues of IMA-treated rats, among 16 compounds, the most abundant ones were the unmetabolized IMA and N-methylanthranilic acid. A collection of the compositional data regarding the anthranilate-related metabolites was statistically treated by multivariate statistical anal. that provided a better insight into the possible biotransformation pathways. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).COA of Formula: C9H11NO2

The Article related to choisya essential oil methyl isopropyl n methylanthranilate organ distribution, isopropyl n-methylanthranilate, metabolite identification, methyl n-methylanthranilate, multivariate statistical analysis, organs distribution, xenobiotic and other aspects.COA of Formula: C9H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 18, 2017, Abe, Takumi; Suzuki, Takuro; Anada, Masahiro; Matsunaga, Shigeki; Yamada, Koji published an article.Recommanded Product: Methyl N-Methylanthranilate The title of the article was 2-Hydroxyindoline-3-triethylammonium Bromide: A Reagent for Formal C3-Electrophilic Reactions of Indoles. And the article contained the following:

A novel indole-2,3-epoxide equivalent, trans-2-hydroxyindoline-3-triethylammonium bromide (I), was found to be a convenient reagent for formal C3-electrophilic reactions of indoles with various nucleophiles. By taking advantage of the nucleophilic character of the oxygen of the 2-hydroxyindoline, the interrupted retro-Claisen and interrupted Feist-Benary reactions with 1,3-dicarbonyl compounds were efficiently achieved. The process was successfully applied to the synthesis of cryptolepine. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: Methyl N-Methylanthranilate

The Article related to hydroxyindole triethylammonium bromide nucleophilic amination substitution indole, cryptolepine preparation, interrupted retro claisen hydroxyindole triethylammonium bromide dicarbonyl compound, feist benary interrupted hydroxyindole triethylammonium bromide cyclic diketone and other aspects.Recommanded Product: Methyl N-Methylanthranilate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Tao; Wei, Xu-Ning; Zhang, Miao; Liu, Yu; Zhu, Li-Min; Zhao, Yun-Hui published an article in 2020, the title of the article was Catalyst and additive-free oxidative dual C-H sulfenylation of imidazoheterocycles with elemental sulfur using DMSO as a solvent and an oxidant.Recommanded Product: Methyl N-Methylanthranilate And the article contains the following content:

Dual C-H sulfenylation was used to obtain 3-vulcanized imidazoheterocycles using odorless elemental sulfur under catalyst- and additive-free conditions. C-H activation of both imidazoheterocycles and arylamines/arenols/indoles was realized by a practical protocol in which DMSO served as both a solvent and an internal oxidant. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: Methyl N-Methylanthranilate

The Article related to arylamine aryl imidazopyridine sulfur regioselective sulfenylation, arylamino thioimidazopyridine preparation antitumor activity, arenol aryl imidazopyridine sulfur regioselective sulfenylation, hydroxyphenyl thioimidazopyridine preparation antitumor activity, indole aryl imidazopyridine sulfur sulfenylation and other aspects.Recommanded Product: Methyl N-Methylanthranilate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 15, 2019, Zhang, Huijuan; Cui, Jiefen; Tian, Guifang; DiMarco-Crook, Christina; Gao, Wei; Zhao, Chengying; Li, Genyuan; Lian, Yunhe; Xiao, Hang; Zheng, Jinkai published an article.Recommanded Product: Methyl N-Methylanthranilate The title of the article was Efficiency of four different dietary preparation methods in extracting functional compounds from dried tangerine peel. And the article contained the following:

Dried tangerine peel (DTP) is an excellent plant resource that has been used as ingredients for both food and traditional Chinese medicine. In this study, the efficiency of four different dietary preparation methods (i.e. soaking, boiling, steaming, and ethanol extraction) in extraction of functional compounds (i.e. flavonoids and essential oil constituents) from DTP was evaluated systematically for the first time. To conduct a comprehensive evaluation of the extraction of the functional compounds, a synthetic evaluation model based on a weighting method was established. The optimum conditions of each dietary preparation method (e.g., time, temperature, solid-liquid ratio, etc.) were determined by response surface methodol. Ethanol extraction showed the best extraction efficiency, followed by soaking, boiling, and steaming. Addnl., different DTP extracts were shown to be clearly distinguished by electronic eye and electronic tongue. This research provides essential findings for the effective dietary instruction of DTP consumption. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: Methyl N-Methylanthranilate

The Article related to boiling, citrus tangerina, essential oils role: bsu (biological study, unclassified), ffd (food or feed use), biol (biological study), uses (uses), flavonoids role: bsu (biological study, unclassified), ffd (food or feed use), biol (biological study), uses (uses), food processing, natural products, plant tissue, peel, solvent extraction, steam heating, tangerine and other aspects.Recommanded Product: Methyl N-Methylanthranilate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 5, 2021, Zhao, Huaibo; Leonori, Daniele published an article.Reference of Methyl N-Methylanthranilate The title of the article was Minimization of Back-Electron Transfer Enables the Elusive sp3 C-H Functionalization of Secondary Anilines. And the article contained the following:

Anilines are some of the most used class of substrates for application in photoinduced electron transfer. N,N-Dialkyl-derivatives enable radical generation α to the N-atom by oxidation followed by deprotonation. This approach is however elusive to monosubstituted anilines owing to fast back-electron transfer (BET). Here we demonstrate that BET can be minimised by using photoredox catalysis in the presence of an exogenous alkylamine. This approach synergistically aids aniline SET oxidation and then accelerates the following deprotonation. In this way, the generation of α-anilinoalkyl radicals is now possible and these species can be used in a general sense to achieve divergent sp3 C-H functionalization. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Reference of Methyl N-Methylanthranilate

The Article related to arylamine arylpyrrolidinone aminobenzonitrile chemoselective photochem preparation, iridium cobalt photoredox catalyst dealkylation addition arylation base mediated, inhibition back electron transfer photochem dealkylation addition alkylarylamine, c−h functionalization, anilines, electron transfer, late-stage modification, photoredox catalysis and other aspects.Reference of Methyl N-Methylanthranilate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics