Category: 84228-44-4

Related Products of 84228-44-4, A common heterocyclic compound, 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, molecular formula is C8H8ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Amino-3-chloro-benzoic acid methyl ester (21.6 mmol) was saponified in EtOH (25 ml) and NaOH (IM5 25 ml) at reflux for 2h. The organic solvent was evaporated and pH adjusted to 4. The product was removed by filtration, washed with water and dried in vacuo to give A- amino-3-chloro-benzoic acid.Yield: 92%IH NMR (D6-DMSO): 6.15 (s, 2H); 6.79 (d, IH); 7.59 (dd, IH); 7.71 (d, IH); 12.37 (br s,IH).

The synthetic route of 84228-44-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. LUNDBECK A/S; WO2006/114093; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 84228-44-4, The chemical industry reduces the impact on the environment during synthesis 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, I believe this compound will play a more active role in future production and life.

Reference Example 8 Methyl 4-amino-3-chlorobenzoate (5.65 g; synthesised in accordance with Synthesis, 1985, 669) was dissolved in tetrahydrofuran (112 ml) and admixed with a solution of sodium hydrogen carbonate (7.67 g) in water (84.8 ml) and benzyl chloroformate (39.1 ml) and the mixture was stirred under a nitrogen atmosphere at room temperature for 22.5 hours. The reaction mixture was extracted with ethyl acetate and the ethyl acetate layer was washed three times with water and then twice with saturated brine. The ethyl acetate layer was dried over magnesium sulfate and then the solvent was distilled off under reduced pressure, and then the residue was purified by column chromatography on silica gel (ethyl acetate/hexane=1:7). A desired fraction was concentrated under reduced pressure and the residue was crystallized from a mixture of ethyl acetate and diisopropyl ether to yield methyl 4-benzyloxycarbonylamino-3-chlorobenzoate (7.51 g) as white crystals. 1H-NMR (CDCl3) delta: 3.91 (3H, s), 5.25 (2H, s), 7.38-7.44 (6H, m), 7.95 (1H, dd, J=8.8 Hz, 2.0 Hz), 8.06 (1H, d, J=2.0 Hz), 8.33 (1H, d, J=8.8 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-3-chlorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6495604; (2002); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, A new synthetic method of this compound is introduced below., SDS of cas: 84228-44-4

A mixture of methyl 4-amino-3-chlorobenzoate (1.0 g, 5.4 mmol), n-pentyl nitrite (0.95 g, 8.1 mmol) and iodine (1.78 g, 7.0 mmol) was stirred under refluxing for 1 h. The mixture was diluted with methylene chloride (30 ml). The purple solution was washed with saturated sodium thiosulfate solution, brine, and dried over sodium sulfate. The title compound was obtained after flash column using EtOAc:hexane/2:98 as the eluant.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK & CO., INC.; WO2007/79186; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 84228-44-4, The chemical industry reduces the impact on the environment during synthesis 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, I believe this compound will play a more active role in future production and life.

Sodium triacetoxyborohydride (3.47 g, 16.39 mmol) was added to a solution of methyl 4-amino-3-chlorobenzoate (1.014 g, 5.46 mmol), cyclopropanecarboxaldehyde (0.816 mL, 10.93 mmol), and acetic acid (1.876 mL, 32.78 mmol) in CH2Cl2 (40 mL). The reaction mixture was stirred at room temperature under nitrogen for 24 h. After concentration, the product was taken up with EtOAc (100 mL), washed with saturated NaHCO3 (3*20 mL), NaCl (20 mL) and dried over Na2SO4. The crude product was purified by MPLC on silica gel using Hex/EtOAc (4:1) to give 1.154 g (88%) of a colorless oil. 1H NMR (400 MHz, CHLOROFORM-D) delta 0.27-0.32 (m, 2H), 0.59-0.65 (m, 2H), 1.09-1.21 (m, 1H), 3.07 (dd, J=7.03, 5.08 Hz, 2H), 3.86 (s, 3H), 4.82-4.95 (m, 1H), 6.59 (d, J=8.59 Hz, 1H), 7.82 (dd, J=8.59, 1.95 Hz, 1H), 7.95 (d, J=1.95 Hz, 1H); MS (ESI) (M+H)+: 240.13.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-3-chlorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; US2009/62251; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, A new synthetic method of this compound is introduced below., Safety of Methyl 4-amino-3-chlorobenzoate

Example 42A Methyl 4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-chlorobenzoate (0510) (0511) To a solution of 1.50 g (3.82 mmol) of the compound from example 2A and 710 mg (3.82 mmol) of 172 methyl 4-amino-3-chlorobenzoate in 15 ml of 49 DMF were added, in small portions at RT, 430 mg (3.82 mmol) of 153 potassium tert-butoxide. The mixture was stirred at RT for 15 min. Subsequently, another 215 mg (1.91 mmol) of potassium tert-butoxide were added in small portions, and the mixture was stirred at RT for a further 2 h. Thereafter, the mixture was introduced into 40 ml of a 10% 83 aqueous citric acid solution while stirring, whereupon there was precipitation of solids. After diluting with water, the solids were filtered off, washed with water and dried under reduced pressure. The crude product thus obtained was purified by means of column chromatography (100 g of silica gel, eluent: cyclohexane/ethyl acetate 85:15, Biotage). 1.60 g (80% of theory, 98% purity) of the 173 title compound were obtained. (0512) 1H-NMR (400 MHz, DMSO-d6): [ppm]=10.96 (s, 1H), 8.14-8.08 (m, 3H), 8.07-8.02 (m, 2H), 7.94 (dd, 1H), 7.66-7.61 (m, 2H), 7.60-7.50 (m, 3H), 3.90 (s, 3H), 2.48 (s, 3H). (0513) LC/MS (Method 1, ESIpos): Rt=1.32 min, m/z=509/511 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Bayer Pharma Aktiengesekkschaft; BECK, Hartmut; THALER, Tobias; KAST, Raimund; MEIBOM, Daniel; MEININGHAUS, Mark; TERJUNG, Carsten; DELBECK, Martina; LUSTIG, Klemens; MUENSTER, Uwe; OLENIK, Britta; (100 pag.)US2017/260140; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 84228-44-4, A common heterocyclic compound, 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, molecular formula is C8H8ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Amino-3-chloro-benzoic acid methyl ester (21.6 mmol) was saponified in EtOH (25 ml) and NaOH (IM5 25 ml) at reflux for 2h. The organic solvent was evaporated and pH adjusted to 4. The product was removed by filtration, washed with water and dried in vacuo to give A- amino-3-chloro-benzoic acid.Yield: 92%IH NMR (D6-DMSO): 6.15 (s, 2H); 6.79 (d, IH); 7.59 (dd, IH); 7.71 (d, IH); 12.37 (br s,IH).

The synthetic route of 84228-44-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. LUNDBECK A/S; WO2006/114093; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84228-44-4, Application In Synthesis of Methyl 4-amino-3-chlorobenzoate

Step 1: methyl 4-amino-3-chlorobenzoate (1.24g, 6.68 mmol) was dissolved in THF (20 ml) followed with Boc anhydride (20.4 ml, 1M in THF) and DMAP (0.1 eq). The mixture was refluxed for 1h15, then it was allowed to reach the room temperature before to evaporate it to dryness.Step 2: The obtained crude was dissolved in MeOH (40 ml), K2CO3 (2.3 g) was added and the mixture was refluxed for 2 h. The mixture was allowed to reach the room temperature, it was then diluted with ether (100 ml) and washed with Brine (3*30 ml), followed with citric acid 0.5 M (10 ml). The organic layer was dried with MgSO4, filtered off and purified on silica gel Biotage column to get the desired compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-amino-3-chlorobenzoate, and friends who are interested can also refer to it.

Reference:
Patent; Genesis Technologies Limited; AHLFORS, Jan-Eric; MEKOUAR, Khalid; (105 pag.)EP2697246; (2018); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84228-44-4, Recommanded Product: 84228-44-4

To a solution of methyl 4-amino-3-chlorobenzoate (0.37g, 0.002 mol) and diisopropylethylamine (0.39g, 0.003 mole) in dioxane at ambient temperature was added in one portion 2-oxo-l ,2-dihydro-3-pyridinecarbonyl chloride (0.4g, 0.002 mol) [prepared as described in WO/201 1/088201 Al]. The mixture was heated at reflux for 24 h. after which it was cooled to ambient temperature and partitioned between EtOAc and water. The two phase material was filtered and the solid was washed with water, then EtOAc and air dried to obtain a 25% yield of the title compound as an off-white solid. MS: m z 305 (MIT) and m/z 307 (MH+). NMR (500 MHz, DMSO-d6): delta 3.848 (s, 3H), 6.604 (t, 1H), 7.878 (qd, 1H), 7.942 (dd, 1H), 8.015 (d, 1H), 8.504 (dd, 1H), 8.744 (d, 1H), 12.787 (br s, 1H), 12.893 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-3-chlorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NORTH CAROLINA CENTRAL UNIVERSITY; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; SEXTON, Jonathan Z.; BRENMAN, Jay E.; WO2014/165816; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics