Category: 83-27-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 83-27-2, name is Diethyl 2-(sec-butyl)malonate, A new synthetic method of this compound is introduced below., name: Diethyl 2-(sec-butyl)malonate

A. 3-sec-Butyl-6-fluoro-4-hydroxyl-2(1H)-quinolinone The title compound was prepared from 4-fluoroaniline (10 g, 80 mmol) and diethyl sec-butylmalonate by the method used in Example 1. Reaction time was 5 d. MS (ES+): m/z 236.0 (M+H); 1H NMR (DMSO-d6) delta 11.2 (bs, 1H, OH), 9.95 (bs, 1H, NH), 7.60 (d, 1H, ArH), 7.31-7.20 (m, 2H, ArH), 3.13 (m, 1H, CH), 1.9 (m, 1H, CH), 1.6 (m, 1H, CH), 1.2 (d, 3H, CH3), 0.7 (m, 3H, CH3).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Andrews,III, Clarence Webster; Freeman, George Andrew; Hopkins, Andrew Lee; US2003/69271; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

83-27-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 83-27-2, name is Diethyl 2-(sec-butyl)malonate, This compound has unique chemical properties. The synthetic route is as follows.

STEP A: 1-(3,4-dichlorophenyl)-4-(sec-butyl)-pyrazolidine-3,5-dione 50 g of 3,4-dichlorophenylhydrazine (85%) and 122.5 g of diethyl sec-butyl-malonate were heated for 10 hours at 180 C. (external temperature) while distilling 21.3 g of ethanol. The remainder was taken up in 200 ml of methylene chloride, and the solution was extracted with 2N sodium hydroxide, then with water. The combined aqueous phases were washed with methylene chloride and acidified to pH 1 by concentrated hydrochloric acid. The precipitate was separated, washed with water, separated, dried under reduced pressure at 40 C. to obtain 64.8 g of 1-(3,4-dichlorophenyl)-4-(sec-butyl)-pyrazolidine-3,5-dione melting at 118-120 C.

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Reference:
Patent; Roussel Uclaf; US4808210; (1989); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics