Category: 82702-31-6

Some common heterocyclic compound, 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, molecular formula is C8H6BrFO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H6BrFO2

To methyl 3-bromo-4-fluorobenzoate (3.02 g, 13.0 mmol) in ether (30 ml) at 0 C. add dropwise MeMgBr (3.0M in ether, 11 ml, 33 mmol). Stir 1 h and pour onto ice. Acidify with 1N HCl, separate the ether, wash with 1N NaHCO3, dry (MgSO4), and concentrate to obtain the product as a colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 82702-31-6, its application will become more common.

Reference:
Patent; Schering Corporation; US2005/239795; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, A new synthetic method of this compound is introduced below., Formula: C8H6BrFO2

Cesium carbonate ((3.1 g, 9.6 mmol) was added to 2,4-difluorophenol (0.83 g, 6.4 mmol) and methyl 3-bromo-4-fluorobenzoate (1.57 g, 6.7 mmol)In a solution of dimethyl sulfoxide (10 mL). The reaction mixture was stirred at 80 C for 12 hr, then cooled to room temperature, then water (50mL), ethyl acetate (50mL*2). The organic phase was washed with brine (25 mL*4) and evaporated to dryness. The crude product was subjected to column chromatography (peel ether: ethyl acetate = 20:1) to give methyl 3-bromo-4-(2,4-difluorophenoxy)benzoate (1.58 g, 4. 72%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Sun Changan; Zhang Xiaoyu; Chen Gangsheng; Zong Shumin; (45 pag.)CN109836385; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 82702-31-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of methyl 3-bromo-4-fluorobenzoate (4.22 g, 18.10 mmol) and Example 1g (2.727 g, 19.46 mmol) in dimethyl sulfoxide (18.10 mL) was treated with cesium carbonate (9.28 g, 28.5 mmol) . The reaction mixture was heated at about 80 C for about 2 hours and cooled to ambient temperature. Water (50 mL) was added, and the reaction mixture was stirred for 10 minutes. The reaction mixture was extracted with methyl tert-butyl ether (1x 100 mL, then 2×50 mL) . The combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by flash chromatography (silica gel, 100% heptanes to 30ethyl acetate: heptanes) to provide the title compound as a white solid (5.29 g, 15.0 mmol, 83% yield) .

The synthetic route of Methyl 3-bromo-4-fluorobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; COWART, Marlon; FIDANZE, Steven; HASVOLD, Lisa; LIU, Dachun; MCDANIEL, Keith; PRATT, John; SHEPPARD, George; WANG, Le; (241 pag.)WO2018/68283; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., name: Methyl 3-bromo-4-fluorobenzoate

Sodium hydride (0.88 g, 22 mmol, 60% w/w) was added to N,N (1r,4r)-4-methylcyclohexane-1-ol (0.84 g, 7.3 mmol) at 0 C – in dimethylformamide (30 mL) solution. The reaction solution was stirred at 0 C for 10 minutes. Then, methyl 3-bromo-4-fluorobenzoate (1.8 g, 8.2 mmol) was added, and the mixture was stirred at room temperature for 10 hours. The reaction was quenched with saturated ammonium chloride, ethyl acetate (50mL * 2), washed with saturated brine (20mL * 5) The organic phase was dried and evaporated to dryness to give a crude product. The crude product was subjected to column separation (petroleum ether: ethyl acetate = 20:1) to give a methyl group. 3-Bromo-4-(((1r,4r)-4-methylcyclohexyl)oxo)benzoate (1.2 g, yield 50%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 82702-31-6.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Ye Guozhong; Liu Lei; Bao Rudi; Wu Shenghua; Deng Haining; (130 pag.)CN110041253; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 82702-31-6, The chemical industry reduces the impact on the environment during synthesis 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, I believe this compound will play a more active role in future production and life.

b) Preparation of methyl 3-bromo-4-[4-(2-hydroxyethyl)piperazin-1-yl]benzoate Methyl 3-bromo-4-fluoro benzoate (1.39 g, 5.96 mmol) was dissolved in N,N-dimethylformamide (12 mL), added 1-piperazineethanol (3.88 g, 29.8 mmol) and potassium carbonate (2.47 g, 17.9 mmol), and the mixture was stirred under microwave irradiation at 100 C. for 0.5 hours. The reaction solution was added water at room temperature, extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (hexane/acetone). The title compound (730 mg (yield 36%)) was obtained as a yellow oil. 1H-NMR (CDCl3) delta: 2.64 (2H, t, J=5.1 Hz), 2.71-2.75 (5H, m), 3.15-3.19 (4H, m), 3.67 (2H, t, J=5.1 Hz), 3.89 (3H, s), 7.03 (1H, d, J=8.6 Hz), 7.94 (1H, dd, J=1.6, 8.6 Hz), 8.22 (1H, d, J=1.6 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-bromo-4-fluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KOWA COMPANY, LTD.; US2010/280013; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 82702-31-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

Potassium carbonate (681 mg, 4.93 mmol) was added to 2-chloro-4-cyclopropyl-6-methylphenol (300 mg, 1.64 mmol) and methyl 3-bromo-4-fluorobenzoate (363 mg, 1.56 mmol) ) in a solution of dimethyl sulfoxide (10 mL). The reaction solution was reacted at 80 C for 5 hours under a nitrogen atmosphere. The reaction solution was cooled and added to water (25 mL). Ethyl acetate extraction (25 mL * 2), the organic phase was dried and evaporated to dryness to give a crude product, the crude product was separated by column ( petroleum ether: ethyl acetate = 20:1) Methyl 3-bromo-4-(2-chloro-4-cyclopropyl-6-methylphenoxy)benzoate (500 mg, yield 77%).

The chemical industry reduces the impact on the environment during synthesis Methyl 3-bromo-4-fluorobenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Ye Guozhong; Liu Lei; Bao Rudi; Wu Shenghua; Deng Haining; (130 pag.)CN110041253; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 82702-31-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

Potassium carbonate (681 mg, 4.93 mmol) was added to 2-chloro-4-cyclopropyl-6-methylphenol (300 mg, 1.64 mmol) and methyl 3-bromo-4-fluorobenzoate (363 mg, 1.56 mmol) ) in a solution of dimethyl sulfoxide (10 mL). The reaction solution was reacted at 80 C for 5 hours under a nitrogen atmosphere. The reaction solution was cooled and added to water (25 mL). Ethyl acetate extraction (25 mL * 2), the organic phase was dried and evaporated to dryness to give a crude product, the crude product was separated by column ( petroleum ether: ethyl acetate = 20:1) Methyl 3-bromo-4-(2-chloro-4-cyclopropyl-6-methylphenoxy)benzoate (500 mg, yield 77%).

The chemical industry reduces the impact on the environment during synthesis Methyl 3-bromo-4-fluorobenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Ye Guozhong; Liu Lei; Bao Rudi; Wu Shenghua; Deng Haining; (130 pag.)CN110041253; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H6BrFO2

4-chloro-2, 6-dimethylphenol (0.672 g, 4.29 mmol), methyl 3 -bromo-4-fluorobenzoate(1.0 g, 4.29 mmol) and cesium carbonate (2.097 g, 6.44 mmol) were combined in dimethylsulfoxide (4.29 mL) under argon in a sealed tube and heated at 80 C for 3 hours. The mixture was partitioned between water and ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by chromatography (silica, 0-30 % ethyl acetate in heptanes)provided the title compound (1.57 g, 93 %).

The synthetic route of 82702-31-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; HASVOLD, Lisa A.; LIU, Dachun; MCDANIEL, Keith F.; PRATT, John; SCHRIMPF, Michael; SHEPPARD, George S.; WANG, Le; LI, Bing; (191 pag.)WO2017/177955; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 82702-31-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

12a In accordance with a method known from the literature, methyl 3-bromo-4-fluorobenzoate is reacted, under (Ph3 P)2 PdCl2 catalysis, with (trimethylsilyl)acetylene to form methyl 4-fluoro-3-(2-trimethylsilylethinyl)benzoate. MS (ES): 251 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-bromo-4-fluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoechst Aktiengesellschaft; US5679712; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82702-31-6, Application In Synthesis of Methyl 3-bromo-4-fluorobenzoate

Methyl 3 -bromo-4-fluorobenzoate (699 mg, 3.00 mmol), 1 -(4-hydroxy-3 , 5- dimethylphenyl)ethanone (493 mg, 3.00 mmol), and cesium carbonate (1.47 g, 4.50 mmol) were combined in dimethyl sulfoxide (3 mL). The reaction mixture was heated at 100 C for 16 hours, cooled to ambient temperature, and partitioned with ethyl acetate and water. The organic layer was washed with saturated aqueous sodium chloride, dried with anhydroussodium sulfate, filtered, and concentrated. The residue was purified by flash chromatography (silica gel, 10-20 % ethyl acetate in heptanes) to provide the title compound (540 mg, 48 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-bromo-4-fluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; HASVOLD, Lisa A.; LIU, Dachun; MCDANIEL, Keith F.; PRATT, John; SCHRIMPF, Michael; SHEPPARD, George S.; WANG, Le; LI, Bing; (191 pag.)WO2017/177955; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics