Category: 81245-24-1

Structure-affinity relationship of the binding of phenolic acids and their derivatives to bovine serum albumin was written by Yuan, Sujing;Zhang, Yunyue;Liu, Jiaxin;Zhao, Yu;Tan, Libo;Liu, Jingwen;Wang, Qingyu;Zhang, Hao. And the article was included in Food Chemistry in 2019.SDS of cas: 81245-24-1 This article mentions the following:

Phenolic acids perform biol. effects which are largely influenced by their binding to serum albumin. Therefore, investigating structure-affinity relationship of binding between phenolic acids and serum albumin is important. In this study, 114 phenolic acids and their derivatives, sharing the benzoic acid core with different substituents groups, were selected to investigate structure-affinity relationships with bovine serum albumin. The binding constants were obtained through fluorescence quenching, and a comprehensive math. model with inner-filter effect correction was applied. The results showed that the hydroxy group at the 2-position led to stronger binding affinity, while it had a neg. influence at the 4-position. Substituting hydroxy groups with methoxy groups at 4-position and with Me groups at 3-position both strengthened the binding affinity, resp. Hydrogen bonding was one of the key binding forces for this binding interaction. Our findings provide a fundamental insight on the binding mechanism of phenolic acids to bovine serum albumin. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1SDS of cas: 81245-24-1).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 81245-24-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Efficient Syntheses of Rugulosin Analogues was written by Snider, Barry B.;Gao, Xiaolei. And the article was included in Journal of Organic Chemistry in 2005.Quality Control of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:

Oxidation of anthracen-1-ones I (R = OH, R¹ = H; R = R¹ = Me; R = CH₂OAc, R¹ = Me) with Pb(OAc)₄ in AcOH for 20 min at 25鎺矯 and 1 h at 75鎺矯 gave flavoskyrin-type dimers, e.g. II, in 53-86% yield. Heating a solution of the flavoskyrin-type dimers in pyridine under air for 1 h at 75-80鎺矯 and then for 1-2 h at 110鎺矯 afforded rugulosin-type dimers, e.g. III, in 61-88% yield. This two-step sequence provides a practical route to this unusual natural product skeleton. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Quality Control of Methyl 2-methoxy-4-methylbenzoate).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Methyl 2-methoxy-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The carboxyl group. Infrared absorption and ionization was written by Peltier, Daniel;Pichevin, Annick. And the article was included in Bulletin de la Societe Chimique de France in 1960.Application of 81245-24-1 This article mentions the following:

PK, ν_OH(monomeric), and ν_C:O (monomeric and dimeric) values of 17 substituted benzoic, 34 o-toluic, 17 m-toluic, and 12 p-toluic acids, as well as the ν_C:O values of 55 Me and Et esters were tabulated. For all the acids except the 6-substituted o-toluic acids (6-NO₂, I, Br, Cl, OH, NH₂), ν_OH (cm.^-1) = 3498 + 9pK. The ν_C:O (monomeric) of the o-OH and o-NH₂ acids were on the average 55 cm.^-1 lower and those of nonchelated, 6-substituted o-toluic acids were approx. 5 cm.^-1 higher than calculated from the appropriate equations (CA 53, 17954e). For acids free of chelation and steric effects, ν_OH = 5,028 – 0.857 ν_C:O (monomeric) (cm.^-1). For 3-, 4-, and 5-substituted o-toluic acids, ν_OH = 5053 – 0.874 ν_C:O. The carbonyl frequencies of the Et esters were approx. 5 cm.^-1 lower than those of the corresponding Me esters. These results are explained by electronic effects of H or alkyl group on the carbonyl group. 6-HO(or H₂N)-2-MeC₆H₃CO₂Me exhibited 2 carbonyl frequencies related to chelated and nonchelated forms. Similar data were presented for 2,3- (I), 2,4-, and 2,6-(MeO)MeC₆H₃CO₂H, and o-MeOC₆H₄CO₂H. The dimeric carbonyl absorptions were weak, the ν_OH were lower, and the ν_C:O were higher, based on the relations with pK, than expected for nonchelated acids. I was exceptional, as it gave a strong dimeric carbonyl absorption. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Application of 81245-24-1).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 81245-24-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The synthesis of 1,5,7,10-tetraoxygenated 3-methylphenanthrenes was written by Finnie, Alistair A.;Hill, Robert A.. And the article was included in Journal of Chemical Research, Synopses in 1987.Formula: C10H12O3 This article mentions the following:

Treating 3,5-(MeO)₂C₆H₃CH₂CN with BuLi and then 4,2,6-Me(MeO)₂C₆H₂CO₂Me gave 4,2,6-Me(MeO)₂C₆H₂COCH(CN)C₆H₃(OMe)₂-3,5 (I). Treating I with Ac₂O and H₂SO₄ and then irradiation gave phenanthrene II (R = cyano, R¹ = Ac) (III). Treating II (R = cyano, R¹ = H) with Raney Ni in HCO₂H gave phenanthrene II (R = R¹ = H). Treating III with Br₂ in AcOH gave mono- and dibromides IV (R²-R⁴ = H, Br), with the product ratios dependent on reaction temperature and stoichiometry. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Formula: C10H12O3).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C10H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, Synthesis, and Structure-Activity Relationship of a Novel Series of GluN2C-Selective Potentiators [Erratum to document cited in CA160:398927] was written by Zimmerman, Sommer S.;Khatri, Alpa;Garnier-Amblard, Ethel C.;Mullasseril, Praseeda;Kurtkaya, Natalie L.;Gyoneva, Stefka;Hansen, Kasper B.;Traynelis, Stephen F.;Liotta, Dennis C.. And the article was included in Journal of Medicinal Chemistry in 2015.Safety of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:

On page 2341, compound 162 in Table 4 should have an isonicotinoyl group in the R₁ position instead of a Me group. On page 2345, compounds 159 and 160 in Table 3 should have a Me group in the 2-position of the indole, and the R¹ should be a Me group instead of the nicotinoyl group shown. After rechecking the purity of all reported compounds, compounds 66-68, 85, 89, 90, 100, and 112 did not meet the J. Med. Chem. purity standards In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Safety of Methyl 2-methoxy-4-methylbenzoate).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Methyl 2-methoxy-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics