Synthetic Route of 80051-07-6, These common heterocyclic compound, 80051-07-6, name is Methyl 4-(1-aminoethyl)benzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred solution ofthe corresponding amine (2 mmol) in anhydrous CH2Cl2 containing drytriethylamine (5 mmol) a solution of 3 or 15a-c (2.5 mmol) in anhydrousCH2Cl2 (5 mL) was added dropwise over 15 min at 0 C. Afterstirred for another 5 h at room temperature, water was added, and themixture was extracted with CH2Cl2. The combined organic phase wasdried (Na2SO4) and filtered to obtain the crude products, which werepurified by column chromatography using silica gel and a CH2Cl2/MeOH mixture. (CH2Cl2: MeOH=100:1)
Statistics shows that Methyl 4-(1-aminoethyl)benzoate is playing an increasingly important role. we look forward to future research findings about 80051-07-6.
Reference:
Article; Hu, Jinhui; An, Baijiao; Pan, Tingting; Li, Zhengcunxiao; Huang, Ling; Li, Xingshu; Bioorganic and Medicinal Chemistry; vol. 26; 21; (2018); p. 5718 – 5729;,
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