Category: 79642-50-5

Solansky, Martin; Mikulasek, Kamil; Zapletalova, Martina; Petrivalsky, Marek; Chiltz, Annick; Zdrahal, Zbynek; Leborgne-Castel, Nathalie; Lochman, Jan published an article in 2021, the title of the article was The oligomeric states of elicitins affect the hypersensitive response and resistance in tobacco.Synthetic Route of 79642-50-5 And the article contains the following content:

Successful plant defense against microbial pathogens is based on early recognition and fast activation of inducible responses. Key mechanisms include detection of microbe-associated mol. patterns by membrane-localized pattern recognition receptors that induce a basal resistance response. A well-described model of such responses to pathogens involves the interactions between Solanaceae plants and proteinaceous elicitors secreted by oomycetes, called elicitins. It has been hypothesized that the formation of oligomeric structures by elicitins could be involved in their recognition and activation of defensive transduction cascades. In this study, we tested this hypothesis using several approaches, and we observed differences in tobacco plant responses induced by the elicitin β-cryptogein (β-CRY) and its homodimer, β-CRYDIM. We also found that the C-terminal domain of elicitins of other ELI (true-elicitin) clades plays a significant role in stabilization of their oligomeric structure and restraint in the cell wall. In addition, covalently crosslinking β-CRYDIM impaired the formation of signalling complexes, thereby reducing its capacity to elicit the hypersensitive response and resistance in the host plant, with no significant changes in pathogenesis-related protein expression. By revealing the details of the effects of β-CRY dimerization on recognition and defense responses in tobacco, our results shed light on the poorly understood role of elicitins′ oligomeric structures in the interactions between oomycetes and plants. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Synthetic Route of 79642-50-5

The Article related to oligomeric elicitin beta cryptogein hypersensitive response tobacco, nicotiana tabacum , phytophthora , cell wall, elicitin response, suppressor of bir1-1 (sobir1), elicitin β-cry, hypersensitive response, oligomeric structure, resistance, signalling, tobacco and other aspects.Synthetic Route of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2021, Pettersson, Pontus; Patrick, Joan; Jakob, Mario; Jacobs, Malte; Kloesgen, Ralf Bernd; Wennmalm, Stefan; Maeler, Lena published an article.Related Products of 79642-50-5 The title of the article was Soluble TatA forms oligomers that interact with membranes: Structure and insertion studies of a versatile protein transporter. And the article contained the following:

The twin-arginine translocase (Tat) mediates the transport of already-folded proteins across membranes in bacteria, plants and archaea. TatA is a small, dynamic subunit of the Tat-system that is believed to be the active component during target protein translocation. TatA is foremost characterized as a bitopic membrane protein, but has also been found to partition into a soluble, oligomeric structure of yet unknown function. To elucidate the interplay between the membrane-bound and soluble forms we have investigated the oligomers formed by Arabidopsis thaliana TatA. We used several biophys. techniques to study the oligomeric structure in solution, the conversion that takes place upon interaction with membrane models of different compositions, and the effect on bilayer integrity upon insertion. Our results demonstrate that in solution TatA oligomerizes into large objects with a high degree of ordered structure. Upon interaction with lipids, conformational changes take place and TatA disintegrates into lower order oligomers. The insertion of TatA into lipid bilayers causes a temporary leakage of small mols. across the bilayer. The disruptive effect on the membrane is dependent on the liposome’s neg. surface charge d., with more leakage observed for purely zwitterionic bilayers. Overall, our findings indicate that A. thaliana TatA forms oligomers in solution that insert into bilayers, a process that involves reorganization of the protein oligomer. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Related Products of 79642-50-5

The Article related to arabidopsis soluble tata structure oligomer cell membrane, chemical crosslinking, circular dichroism, electron microscopy, fluorescence correlation spectroscopy, light scattering, membrane insertion, membrane leakage, oligomer, twin-arginine translocase, vesicles and other aspects.Related Products of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2021, Lin, Han; Hong, Haofei; Feng, Lipeng; Shi, Jie; Zhou, Zhifang; Wu, Zhimeng published an article.Synthetic Route of 79642-50-5 The title of the article was Synthesis of DNP-modified GM3-based anticancer vaccine and evaluation of its immunological activities for cancer immunotherapy. And the article contained the following:

Tumor-associated carbohydrate antigens (TACAs) are attractive targets for vaccine development. In this context, we described a strategy combining artificial TACA and glyco-engineering for cancer vaccine development. A 2,4-ditrophenyl (DNP)-modified GM3 intermediate was synthesized chemo-enzymically and conjugated to keyhole limpet hemocyanin (KLH), and the resulting bioconjugate was tested for its potential as a vaccine candidate. Mice immunol. studies revealed that the DNP-modified GM3 (GM3-NHDNP) analog elicited strong and rapid immune responses by recruiting anti-DNP antibodies to facilitate the targeted delivery of the vaccine construct to antigen processing cells (APCs). Moreover, the endogenously produced anti-DNP antibodies, together with the elicited antibodies against GM3-NHDNP, may synergistically promote tumor binding and cancer cell death when the cancer cell surfaces are glycoengineered to express the GM3-NHDNP antigen. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Synthetic Route of 79642-50-5

The Article related to ifn il6 igg igm sialooligosaccharide preparation apoptosis, human serum albumin bioconjugate sialooligosaccharide preparation sialic aldolase, keyhole limpet hemocyanin bioconjugate vaccine tumor associated carbohydrate antigen, dnp gm3 sialooligosaccharide preparation antitumor antigen vaccine antibody prodrug and other aspects.Synthetic Route of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2016, Shi, Qixun; Masseroni, Daniele; Rebek, Julius published an article.Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Macrocyclization of Folded Diamines in Cavitands. And the article contained the following:

In the presence of a water-soluble cavitand, long-chain alkanediamines H2N(CH2)nNH2 (n = 11, 12, 14, 16, 18) underwent chemoselective monoacylation and macrolactamization reactions in water. The cavitand binds diamines in folded conformations that bury the hydrocarbon chains and expose the amino groups to the aqueous medium. Acylation of diamines H2N(CH2)nNH2 (n = 11, 12, 14, 16) with succinic anhydride in water in the presence of the water-soluble cavitand provided monofunctionalized amido acids HO2CCH2CH2CONH(CH2)nNH2 (n = 11, 12, 14, 16) in 64-71% yields, approx. twice the yields obtained in the absence of the cavitand. The C11- and C12-amido acids underwent macrocyclization to dilactams in the presence of the water-soluble cavitand using the coupling reagent EDC and a sulfonated N-hydroxysuccinimide in higher yields than in the absence of the cavitand. Direct reaction of diamines H2N(CH2)nNH2 (n = 11, 12, 14, 16, 18) with the N-hydroxysuccinimide diesters of succinic acid and glutaric acids in the presence of the water-soluble cavitand resulted in 54-96% yields of 17- to 25-membered dilactams, with three- to ten-fold increases in yield over reactions performed in the absence of the cavitands. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to macrolactam chemoselective preparation, succinic anhydride chemoselective acylation diamine water soluble cavitand catalyst, chemoselective macrolactamization diamine amido acid water soluble cavitand catalyst,hydroxysuccinimide succinate glutarate ester chemoselective macrolactamization diamine cavitand catalyst and other aspects.Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiong, Chenghe; Feng, Shaojie; Qiao, Yin; Guo, Zhongwu; Gu, Guofeng published an article in 2018, the title of the article was Synthesis and Immunological Studies of Oligosaccharides that Consist of the Repeating Unit of Streptococcus pneumoniae Serotype 3 Capsular Polysaccharide.Synthetic Route of 79642-50-5 And the article contains the following content:

A highly convergent and efficient strategy was developed for the chem. synthesis of complex oligosaccharides of Streptococcus pneumoniae type 3 capsular polysaccharides that contain multiple glucuronic acid units. Once the oligo-glucosides were efficiently and stereoselectively assembled, the designated glucose units were regioselectively oxidized to glucuronic acid in one step at the final synthetic stage, which helped avoid difficult glycosylation that involved glucuronic acid. The target oligosaccharides had a free amino group at the reducing terminus and varied caps at the non-reducing terminus to enable further modification and structure-activity relationship studies. Immunol. evaluations of the oligosaccharide-tetanus toxoid conjugates showed that they elicited robust T-cell-dependent IgG antibody responses and that the sugar chain length had a major impact on their immunol. properties. In particular, the penta- and hexasaccharides were identified as promising antigens for vaccine development. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Synthetic Route of 79642-50-5

The Article related to bovine serum albumin tetanus toxoid glucuronic acid oligosaccharide preparation, structure activity igg antibody glycosylation glucuronic acid oligosaccharide, igg antibody vaccine tetanus toxoid glycosylation glucuronic acid oligosaccharide, oligosaccharide preparation immunol repeating unit streptococcus pneumoniae polysaccharide and other aspects.Synthetic Route of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics