Extended knowledge of 79538-28-6

According to the analysis of related databases, 79538-28-6, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 79538-28-6, name is Methyl 2,4,6-trifluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H5F3O2

a) 4-Dimethylamino-2.6-difluoro-benzoic acid methyl ester (6a) To a stirred solution of 4,28 g (22.5 mmol) 2.4,6-Trifluoro-benzoic acid methyl ester (Apollo) and 60.0 ml dimethylsulphoxid are added 2.23 g (27.0 mmol) dimethylamine hydrochloride and 6.54 g (47.3 mmol) potassium carbonate. The reaction mixture is stirred for 5h at 55C in an autoclave and is reduced with high vacuum rotation evaporator at 65C. The residue is diluted with dichloromethane, washed twice with water. The combined water phases are extracted with dichloromethane. The combined dichloromethane phases are washed with diluted sodium hydrogen carbonate solution, dried with sodium sulphate and concentrated. The oily crude is purified by column chromatography and the desired product 6a is obtained in 74 % yield (3.59 g, 16.7 mmol). MS-ESI: 216 (M+ +1,69).

According to the analysis of related databases, 79538-28-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer Schering Pharma Aktiengesellschaft; EP1897885; (2008); A1;,
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