Category: 792-74-5

Electric Literature of 792-74-5, These common heterocyclic compound, 792-74-5, name is Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2 [[1,1′-trans, trans-Bicyclohexyl]-4,4′-diylbis[4,2-oxazoldiyl(2S)-2,1-pyrrolidinyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-carbamic acid dimethyl ester 20 4,4′-Dimethyl biphenyl-4,4′-dicarboxylate 20.1 (9 g, 33 mmol) was hydrogenated in AcOH (100 ml) in the presence of 10percent Pd/C (3 g) and Rh2O3 (0.15 g) at 250° C. for 16 h and pressure of 60-20 atm H2. After that the mixture was filtered off, evaporated at reduced pressure, excess of 10percent K2CO3 solution in water was added and the mixture was extracted with CHCl3. Organic layer was evaporated, it gave 9 g (96percent) of compound 20.2. 1H NMR (CDCl3): 3.67 (s); 3.65 (s) (total 6H, 2Me) 2.56 (1H, br.s) 2.20 (br.t., 1H) 2.0 (m, 4H) 1.80 (br.t, 2H) 1.5-1.0 (m, 12H).

Statistics shows that Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate is playing an increasingly important role. we look forward to future research findings about 792-74-5.

Reference:
Patent; Alla Chem LLC; Ivachtchenko, Alexandre Vasilievich; Bichko, Vadim Vasilievich; Mitkin, Oleg Dmitrievich; US2013/253008; (2013); A1;,
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Reference of 792-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 792-74-5, name is Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A sample of 4,4′-biphenyldicarboxylate dimethyl ester, 2.0 g, was place in a 50 ml 2 neck 24/40 flask with stirring bar. Then trifluoroacetic acid, 10 ml, was added, and the mix was cooled to 0 0C. The cooled mixture was treated with 90% nitric acid, 0.38 ml, and then trifluoroacetic anhydride , 1.91 ml was added dropwise. TLC with 1 :8 ethyl acetate/hexanes on silica ant 30 minutes post TFAA showed some SM, and a new lower RF product. The mix was stirred 1 hour at 0 0C, then 3 hours at room temperature. The mixture was then poured into 100 ml of cold water, giving a gummy precipitate. The mix was treated with 80 ml of ethyl acetate and 20 ml of hexanes. The layers were separated, and the organic layer was washed with 100 ml of water. The organic layer was then stirred with 20 g of sodium bicarbonate in 100 ml of water. The ethyl acetate was evaporated in vacuo. The residue was treated with 100 ml of hexanes, heated to a boil, and diluted with ethyl acetate hot until a solution was obtained, then hexanes was added to a total volume of 200 ml. The mix was cooled to room temperature, and the resulting solids were collected by filtration, washed with 10 ml hexanes, and air dried to give 2-nitro-4,4′-biphenyldicarboxylate dimethyl ester, 1.319 g.NMR 500 MH D6DMS0: 8.51, d, J=IJ, IH, 8.31, dd, J=U, 8.1, IH, 8.06, dd, J=1.8, 8.3, 2H, 7.76, d, J=8, IH, 7.56, dd, J=1.8, 8.4, 2H, 3.94, s, 3H, 3.89, s, 3H

The synthetic route of Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IMMUSOL INCORPORATED; WO2008/21745; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 792-74-5, name is Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate

The detailed procedure is as follows; to the solution of MBPDC (600 mg, 2.22 mmol) in 40 mL acetic acid, 20 mL of4:1 (v/v) H2SO4/H2O solution was added. Then the reaction mixture was refluxed for 24 h at 120C. The product was washed thoroughl ywith ethanol and dried in oven at 80¡ãC overnight (Yield: 520 mg,96.6percent).

The synthetic route of 792-74-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Medabalmi, Veerababu; Ramanujam, Kothandaraman; Journal of the Electrochemical Society; vol. 164; 7; (2017); p. A1720 – A1725;,
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Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 792-74-5, name is Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 792-74-5

General procedure: To a solution of benzo[b]thiophene (8) (2.15g, 16.0mmol) in 20ml dry THF under an argon atmosphere at?30¡ãC, n-BuLi (10.0ml, 16.0mmol, 1.6M n-hexane) was added slowly. The mixture was treated with the corresponding ester and stirred at room temperature. After quenching with saturated aqueous NH4Cl-solution, the residue was extracted with CHCl3. The organic phase was dried (Na2SO4) and the solvent evaporated.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Katzsch, Felix; Gruber, Tobias; Weber, Edwin; Journal of Molecular Structure; vol. 1114; (2016); p. 48 – 64;,
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Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 792-74-5, name is Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 792-74-5, 792-74-5

a) Preparation of 4,4′-bis (Hydroxy-Methyl) Biphenyl. 789mg (20.8 mmoles) of LiAlH4 in 150ml of anhydrous THF (tetrahydrofuran) are placed in a 2-litre flask which has a mechanical agitator, cooler, filler funnel and heating bath. A solution, heated to 50oC, of 7.5g (27.7 mmoles) of 4,4′-bis (methoxycarbonyl)biphenyl in 500ml of anhydrous THF is added dropwise, over a period of 1 hour, to the mixture, heated in an inert atmosphere to 50oC under agitation. After a further 30 minutes of agitation in a heating bath, the mixture is cooled to ambient temperature and the excess LiAlH4 is destroyed by the careful addition of 15ml of a THF/H2O (80:20) mixture. The reaction mixture is filtered on Septum G2, washing the precipitate with anydrous ethanol (3x100ml). The combined filtrate and washings are evaporated to dryness under vacuum with the heating bath at 40oC. The residue is then redissolved with 100ml of hot acetone (50oC), eliminating the insoluble residue by filtration, dried on anhydrous Na2SO4 and evaporated to dryness. 5.74g of 4,4′-bis (hydroxymethyl) biphenyl are obtained with a molar yield of 96.6percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl [1,1′-biphenyl]-4,4′-dicarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ENIRICERCHE S.p.A.; EP469682; (1992); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics