Reference of 79025-26-6,Some common heterocyclic compound, 79025-26-6, name is Methyl 2-amino-5-chloro-4-methoxybenzoate, molecular formula is C9H10ClNO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of compound 2 (26 g, 167 mmol) in a solution of NaOH (13.4 g, 0.334 mmol) in water (400 mL) was stirred at r.t. overnight, after which time complete reaction was observed by TLC. The reaction was acidified with 2N HCl and filtered, washed with water, and dried to provide the desired product as a white solid (30 g, 90% yield). NMR (400 MHz, DMSO-d6) delta: 7 62 (IH, s), 6.44 (IH, s), 3.80 (3H, s).
The synthetic route of 79025-26-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CEREPEUT, INC.; LU, Bingwei; (43 pag.)WO2019/55528; (2019); A1;,
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