Category: 7778-83-8

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7778-83-8 as follows. Application In Synthesis of Propyl 3-Phenylacrylate

The substrate is used cinnamic acidPropyl ester (47.6mg, 0.2mmol) and (S) -1,1′- binaphthyl-2,2′-diyl hydrogen phosphate (73.1mg, 0.21mmol, 1.01Equiv.), Was addedAfter N- bromosuccinimide, 30h is reacted, and other experimental conditions were the same method as in Example 1, to obtain a colorless oily liquid 97.2mg, yield 70.7%.Two non enantiomers by high performance liquid chromatography )The chalcone (41.6mg, 0.2mmol) and (R / S) -1,1′- binaphthyl-2,2′-diyl hydrogen phosphate (73.1mg, 0.21mmol, 1.01Equiv.) Was dissolved in 2mLTHF ; and at room temperature, under argon atmosphere, was slowly every 2hWas added N- bromosuccinimide (0.1mmol, 0.5Equiv.) For a total of 4 times was added, N- bromosuccinimide was added, reaction was continued for 24h, the solvent was removed under reduced pressure, the residue by column chromatography gel (ethyl acetate: n-hexane; (1: 10, V / V, 100mL), (1: 5, V / V100mL), (1: 3, V / V, 200mL)), to give a colorless oily liquid121.7mg, yield 86%.The product form two diastereomers by high performance liquid.

According to the analysis of related databases, 7778-83-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dalian Institute of Chemical Physics; Zhao, Zongbao; Suo, Heier; Liu, Wujun; (44 pag.)CN105524110; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 7778-83-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7778-83-8 as follows.

General procedure: To a deoxygenated solution of ethyl cinnamate (176 mg, 1 mmol)and NaN3 (98 mg, 1.5 mmol) in anhydrous MeCN, a deoxygenatedsolution of CAN (1.370 g, 2.5 mmol) in the same solvent (10 mL)was added dropwise at 0 C and stirred well. H2O (400 mL) wasadded to the reaction mixture and the aqueous layer was extractedwith CH2Cl2 (4 × 150 mL). The combined organic extracts werewashed with H2O (2 × 100 mL), and dried over anhydrous Na2SO4.The crude residue, on treatment with anhydrous NaOAc (123 mg,1.5 mmol) in anhydrous acetone (5 mL), followed by usual workupand purification by silica gel column chromatography using petroleumether-EtOAc (98:2) as eluent, afforded 2a as a pale yellowviscous liquid.

According to the analysis of related databases, 7778-83-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hu, Manman; He, Xinwei; Niu, Zhiqiang; Yan, Zhenglei; Zhou, Fuyin; Shang, Yongjia; Synthesis; vol. 46; 4; (2014); p. 510 – 514;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics