Application of 773134-84-2, The chemical industry reduces the impact on the environment during synthesis 773134-84-2, name is Ethyl 1-bromo-2-naphthoate, I believe this compound will play a more active role in future production and life.
86.3g of (362.55 mmol) of 9,9-dimethyl-fluorene-2-boronic acid,92g (329.59 mmol) of ethyl bromonaphthalene-2-carboxylate 159.4g of (692 mmol)Tripotassium phosphate monohydrate,450ml of toluene,And dioxane of 230mlSuspended in water 700mlIt is,6.0g of (19.8 mmol)Tris -o- tolyl phosphineFollowing,Palladium acetate 740 mg (3.3 mmol) was added,Mixture,It is heated for 4 hours boiling.The organic phase is isolated,It is filtered through silica gel,It is vacuum evaporation.The residue,It is recrystallized from heptane.Yield: colorless solid 100.6g (78%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-bromo-2-naphthoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK PATENT GMBH; BUESING, ARNE; STOESSEL, PHILIPP; HEIL, HOLGER; (94 pag.)JP5666130; (2015); B2;,
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