Category: 764667-64-3

Electric Literature of 764667-64-3,Some common heterocyclic compound, 764667-64-3, name is 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, molecular formula is C14H11F3O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

547 gm of 4-oxo-4-[3-(trifiuoromethyl)-556-dihydro[l,2,4]triazolo[4,3-alpha]pyrazin-7(8H)- yl]-l-(2,4,5-trifiuororhohenyl)butan-2-one (Formula V) was obtained by adding 500 gm of 5-[l-hydroxy-2-(2,4,5-trifluorophehy)ethylidene]-2,2-dimethyl-l ,3-dioxane-4,6- dione in to the solution 5000 ml toluene containing 440 gm of ‘ 3-(trifluoromethyl)-5,6,7,8-tetrahydro[l,2,4]triazolo[4,3-?]pyrazine .hydrochloride (Formula VI) and 1100 ml of diisopropyl ethylamine at 25-3O0C followed by heating the reaction mass to toluene reflux temperature till the completion of reaction monitor by TLC or HPLC. Isolation of the above said product done by’, ethylacetate and. aqueous -acidic workup followed by distillation.The isolated compound has been characterized by, Mass and HPLC purity. Mass : 407.18 [M+H]+HPLC purity ‘ . : NLT – 85 %. ‘ ‘ ‘ i

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, its application will become more common.

Reference:
Patent; GLENMARK GENERICS LIMITED; WO2009/84024; (2009); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 764667-64-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 764667-64-3, name is 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, This compound has unique chemical properties. The synthetic route is as follows.

A round bottom flask is charged with 3-trifluoromethyl-5,6,7,8-tetrahydro- 1 ,2,4-thazolo[4,3a]pyrazine hydrochloride (144.6 g) and ethyl acetate (2000 ml_) at 28C, then N-methylmorpholine (67.2 g) is added. 5-[1 -hydroxy-2-(2,4,5- trifluorophenyl)ethyledine]-2,2-dimethyl-1 ,3 dioxane-4,6-dione (200 g) is added and the mixture is heated to reflux for 6 hours. The mixture is slowly cooled to room temperature. Water (1000 ml_) is added, the mixture is stirred for 15 minutes, and the organic layer is separated. The aqueous layer is extracted with ethyl acetate (200 ml_). The two organic layers are combined and solvent is distilled at 37C. Toluene (400 ml_) is added to the residue and stirred for 3 hours. The solid is filtered, washed with toluene (200 ml_), and dried under reduced pressure at 500C for 12.5 hours, to afford the title compound. (252.0 g, 98.1 % yield).

The chemical industry reduces the impact on the environment during synthesis 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; GUDIMALLA, Nagaraju; DWIVEDI, Namrata; CHETLURU, Kiran Kumar; GADE, Srinivas Reddy; MUVVA, Venkateswarlu; SRIVASTAVA, Bindu; WO2011/25932; (2011); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 764667-64-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 764667-64-3, name is 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, This compound has unique chemical properties. The synthetic route is as follows.

A round bottom flask is charged with 3-trifluoromethyl-5,6,7,8-tetrahydro- 1 ,2,4-thazolo[4,3a]pyrazine hydrochloride (144.6 g) and ethyl acetate (2000 ml_) at 28C, then N-methylmorpholine (67.2 g) is added. 5-[1 -hydroxy-2-(2,4,5- trifluorophenyl)ethyledine]-2,2-dimethyl-1 ,3 dioxane-4,6-dione (200 g) is added and the mixture is heated to reflux for 6 hours. The mixture is slowly cooled to room temperature. Water (1000 ml_) is added, the mixture is stirred for 15 minutes, and the organic layer is separated. The aqueous layer is extracted with ethyl acetate (200 ml_). The two organic layers are combined and solvent is distilled at 37C. Toluene (400 ml_) is added to the residue and stirred for 3 hours. The solid is filtered, washed with toluene (200 ml_), and dried under reduced pressure at 500C for 12.5 hours, to afford the title compound. (252.0 g, 98.1 % yield).

The chemical industry reduces the impact on the environment during synthesis 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; GUDIMALLA, Nagaraju; DWIVEDI, Namrata; CHETLURU, Kiran Kumar; GADE, Srinivas Reddy; MUVVA, Venkateswarlu; SRIVASTAVA, Bindu; WO2011/25932; (2011); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 764667-64-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 764667-64-3 as follows.

Under stirring at room temperature, to a 2L three-necked reaction flask equipped with 800mL of acetonitrile,The compound obtained in Example 1 (316.2 g, 1.0 mol, 1 eq)After it is completely dissolved,Add in an ice bath(R) -tert-butylsulfenamide(133.3 g, 1.1 mol, 1.1 eq),After adding the system slowly warmed to room temperature,65 C overnight,TLC detection of the reaction process, the reaction was completed, remove most of the solvent, add water,Dichloromethane extraction, the combined organic phase was dried over anhydrous sodium sulfate,Remove the solvent, methanol and methylene chloride solution to give a white solid,Yield 81%.

According to the analysis of related databases, 764667-64-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suzhou Aimate Biological Technology Co., Ltd.; Wang Mingzhong; Zhu Mingxin; Su Dao; Liu Junpeng; (14 pag.)CN107501112; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 764667-64-3 as follows. HPLC of Formula: C14H11F3O5

Under nitrogen protection,Acetonitrile (284 mL) was added to a 250 mL three-necked flask in sequence,Compound C (56.7 g, 0.179 mol) and benzyl alcohol (19.4 g, 0.179 mol),Stirring.Heating to reflux(The internal temperature of 80 ~ 84 for the normal boiling point)About 24 hours.Cooling to below 30 ,concentrate,3 V methanol was added,0 ~ 5 crystallization of 12h,Filtered product 47.2g,Yield 81.6%.

According to the analysis of related databases, 764667-64-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai SynCores Technologies, Inc.; Qian, Wangke; Hong, Jian; Wang, Yusheng; Wang, Boyu; Huang, Luning; Gu, Hong; (8 pag.)CN105566138; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A common heterocyclic compound, 764667-64-3, name is 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, molecular formula is C14H11F3O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 764667-64-3.

2,4, 5-TRIFLUOROPHENYLACETIC acid (2-1) (150 g, 0.789 mol), Meldrum’s acid (125 g, 0. 868 mol), and 4- (DIMETHYLAMINO) pyridine (DMAP) (7.7 g, 0063 mol) were charged into a 5 L three-neck flask. N, N-DIMETHYLACETAMIDE (DMAC) (525 ML) was added in one portion at room temperature to dissolve the solids. N, N-diisopropylethylamine (282 ML, 1.62 mol) was added in one portion at room temperature while maintaining the temperature below 40 C. Pivaloyl chloride (107 ML, 0.868 mol) was added dropwise over 1 to 2 h while maintaining the temperature between 0 and 5 C. The reaction mixture was aged at 5 C for 1 h. Triazole hydrochloride 1-4 (180 g, 0.789 mol) was added in one portion at 40-50 C. The reaction solution was aged at 70 C for several h. 5% Aqueous sodium hydrogencarbonate solution (625 ML) was then added dropwise at 20-45 C. The batch was seeded and aged at 20-30 C for 1-2 h. Then an additional 525 mL of 5% aqueous sodium hydrogencarbonate solution was added dropwise over 2-3 h. After aging several h at room temperature, the slurry was cooled to 0-5 C and aged 1 h before filtering the solid. The wet cake was displacement-washed with 20% aqueous DMAC (300 mL), followed by an additional two batches of 20% aqueous DMAC (400 mL), and finally water (400 mL). The cake was suction-dried at room temperature. The isolated yield of final product 2-3 was 89%.

The synthetic route of 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2005/20920; (2005); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A common compound: 764667-64-3, name is 5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 764667-64-3

2,4,5-Trifluorophenylacetic acid (2-1) (150 g, 0.789 mol), Meldrum’s acid (125 g, 0.868 mol), and 4- (dimethylamino)pyridine (7.7 g, 0063 mol) were charged into a 5 L three-neck flask. N,N-Dimethylacetamide (DMAc) (525 mL) was added in one portion at room temperature to dissolve the solids. N,N-diisopropylethylamine (282 mL, 1.62 mol) was added in one portion at room temperature while maintaining the temperature below 40 C. Pivaloyl chloride (107 mL, 0.868 mol) was added dropwise over 1 to 2 h while maintaining the temperature between 0 and 5 C. The reaction mixture was aged at 5 C for 1 h. Triazole hydrochloride 1-4 (180 g, 0.789 mol) was added in one portion at 40-50 C. The reaction solution was aged at 70 C for several h. 5% Aqueous sodium hydrogencarbonate solution (625 mL) was then added dropwise at 20 – 45 C. The batch was seeded and aged at 20 – 30 C for 1-2 h. Then an additional 525 mL of 5% aqueous sodium hydrogencarbonate solution was added dropwise over 2-3 h. After aging several h at room temperature, the slurry was cooled to 0 – 5 C and aged 1 h before filtering the solid. The wet cake was displacement-washed with 20% aqueous DMAc (300 mL), followed by an additional two batches of 20% aqueous DMAc (400 mL), and finally water (400 mL). The cake was suction-dried at room temperature.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 764667-64-3, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; SOLVIAS AG; WO2005/97733; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics