Category: 756525-95-8

These common heterocyclic compound, 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of tert-Butyl 9-Amino-4,7-dioxanonanoate

SI-22 (270 mg, 1.03 mmol, 1.2 eq.), COMU (440 mg, 1.03 mmol, 1.2 eq.), and N- methylmorpholine (283 pL, 2.57 mmol, 3 eq.) were dissolved in 1.5 mL of DMF and stirred for 1 min. Amino-PEG2-t-butyl ester (200 mg, 0.86 mmol, 1 eq.) was added in 2.5 mL of DMF and the reaction was stirred at room temperature for 1 h. The reaction was diluted with ethyl acetate (lOmL) and the organic phase washed with water (3xl5mL) and brine (lxl5mL). The organic layer was separated, dried over anhydrous MgSCE, and concentrated. The residue was purified by flash chromatography (DCM/EtOAc; 1 : 1) to provide the title compound as a colorless oil (212 mg, 43%). NMR (500 MHz, Chloroform-7) d 7.01 (t, J= 5.7 Hz, 1H), 6.71 (dt, J= 8.7, 2.4 Hz, 1H), 6.68 (s, 1H), 4.43 (s, 2H), 3.74 – 3.69 (m, 2H), 3.67 (td, J= 6.4, 2.0 Hz, 2H), 3.55 (d, j= 2.3 Hz, 4H), 3.51 (ddd, j= 6.5, 3.4, 1.5 Hz, 2H), 2.65 (s, 2H), 2.48 – 2.40 (m, 4H), 2.18 (qd, J= 7.6, 2.1 Hz, 1H), 1.90 (td, j= 6.6, 1.8 Hz, 2H), 1.41 (d, 7= 1.5 Hz, 2H), 1.40 (d, 7= 2.3 Hz, 9H), 1.11 (td, 7= 7.8, 2.6 Hz, 3H). HRMS (ESI) [M+Na]+ for C25H38N207Na 501.2571, found 501.2580.

The synthetic route of tert-Butyl 9-Amino-4,7-dioxanonanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; ZHANG, Xiaoyu; CROWLEY, Vincent; CRAVATT, Benjamin; (121 pag.)WO2020/77278; (2020); A1;,
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Adding a certain compound to certain chemical reactions, such as: 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756525-95-8, Formula: C11H23NO4

Preparation of (9H-fluoren-9-yl)methyl 2-((1-(3-(4-((2-(2-(3-(tert-butoxy)-3- oxopropoxy)ethoxy)ethyl)amino)piperidin-1-yl)-3-oxopropyl)-1H-indol-2-yl)methyl)-1,2- dimethylhydrazine-1-carboxylate (Fmoc-HIPS-PAPip(PEG2(CO2t-Bu))NH) (Figure 62) To a dried scintillation vial containing a magnetic stir bar was added Fmoc-HIPS- piperidinone (355 mg, 0.63 mmol), H2N-PEG2-COOtBu (175 mg, 0.76 mmol), 4 A molecular sieves (activated powder, 100 mg), and 1,2-dichloroethane (2.5 mL). The mixture was stirred for 1 h at room temperature. To the reaction mixture was added sodium triacetoxyborohydride (314 mg, 1.48 mmol). The mixture was stirred for 18 hours at room temperature. The resulting mixture was partitioned between EtOAc and saturated aqueous NaHCO3. The organic layer was washed with saturated aqueous NaHCO3 (2 x 5 mL), and brine (1 x 5 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure to yield the title compound as a yellow oil, which was carried forward without further characterization.

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Reference:
Patent; REDWOOD BIOSCIENCE, INC.; RABUKA, David; ALBERS, Aaron Edward; KUDIRKA, Romas Alvydas; GAROFALO, Albert W.; WO2015/81282; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 756525-95-8, These common heterocyclic compound, 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of (6-((3-(3-(5-methyl-lH-imidazol-l-yl)-5- (trifluoromethyl)benzamido)benzyl)amino)-2H-indazole-3-carbonyl)-L-alanine (16) (170 mg, 0.28 mmol, 1.0 equiv) in DMF (6.8.0 mL, 40.0 vol. equiv) were added tert-butyl 3-(2-(2- aminoethoxy)ethoxy)propanoate (16) (78.60 mg, 0.34 mmol, 1.2 equiv), HATU (320 mg, 0.84 mmol, 3.0 equiv) and DIPEA (43.5 mg, 0.34 mmol, 1.20 equiv). The reaction mixture was stirred for 4 h at RT. The completion of reaction was monitored by TLC. The Reaction mixture was quenched with DMW (100 mL) and extracted with EtOAc (100 mL x 3). The combined organic extract was washed with brine (100 mL), dried over Na2S04 and concentrated under vacuum to get crude of desired compound. The crude was purified with column chromatography eluted with methanol in DCM (0 to 10%) to afford titled compound (17) (220 mg, 95.5%) as a light brown gum. 1H MR (300 MHz, OMSO-d6) delta 12.90 (s, 1H), 10.59 (s, 1H), 8.68 (s, 1H), 8.46 (s, 1H), 8.32-8.16 (m, 4H), 7.79-7.69 (m, 4H), 7.39-7.34 (t, 1H), 7.21-7.19 (d, 1H), 6.76-6.8 (s, 2H), 6.35 (s, 1H), 4.46-4.36 (m, 3H), 4.12-4.00 (t, 2H), 3.63-3.41 (m, 8H), 2.94 (s, 2H)2.21 (s, 3H), 1.45-1.38 (m, 12H). MS (ES+): 821.3 (M+l); MS (ES-): 819.5 (M-l).

Statistics shows that tert-Butyl 9-Amino-4,7-dioxanonanoate is playing an increasingly important role. we look forward to future research findings about 756525-95-8.

Reference:
Patent; QUARTZ THERAPEUTICS, INC.; ZAMBONI, Robert; HENNING, Ryan; JI, Alan; SMITH, Tyler; HELLER, Bradley; REDDY, Thumkunta Jagadeeswar; ROCHELEAU, Sylvain; BEAULIEU, Marc Andre; (266 pag.)WO2018/200981; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 756525-95-8,Some common heterocyclic compound, 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, molecular formula is C11H23NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of carboxylic acid 10 (30 mg, 0.125 mmol), HATU (53 mg, 1.38 mmol) and DIPEA (70 L, 0.375 mmol) in DMF (5 mL) at 25 C was added the corresponding primary amine (33 mg, 0.138 mmol). The reaction mixture was stirred for 16 h, diluted with 0.1 N aqueous NaOH (15 mL) and extracted with CH2C12 (3 x 20 mL). The combined organic phases were dried over anhydrous Na2S04 and concentrated under reduced pressure. The residue was purified by flash column chromatography (0-5 % MeOH in DCM) to give compound M (18 mg, 0.040 mmol, 32% yield). MS (ESI) m/z 456 (M+H)+

The synthetic route of 756525-95-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; GRAY, Nathanael S.; HAGGARTY, Stephen J.; CAI, Quan; TELO BAPTISTA LIMA DA SILVA, Maria Catarina; ZHANG, Tinghu; FERGUSON, Fleur M.; (220 pag.)WO2019/14429; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: tert-Butyl 9-Amino-4,7-dioxanonanoate

To a solution of Z-Glu-OBz (0.5 g, 1.356 mmol) in CH2CI2 (3 mL) was added amino-DPEG2 t-buty ester (3 14 mg, 1.35 mmol), HATU (614 mg, 1.62 mmol), HO At (220 mg, 1 62 mmol) and TEA (0.563 ml, 4.04 mmol). The reaction mixture was stirred overnight at room temperature, diluted with EtOAc, and washed with brine (3x). The organic phase s dried over Na2S04, and concentrated. The crude product was purified on silica gel (ISCO, 40 g, 0-10 % MeOH / DCM eluent) to afford compound 74 (390 mg, 49.4 % yield). ESI MS: C31H42N2O9 (M+H) 587.3; found 587 3

According to the analysis of related databases, 756525-95-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERSANA THERAPEUTICS, INC.; THOMAS, Joshua D.; JONES, Brian D.; KELLEHER, Eugene W.; LOWINGER, Timothy B.; YANG, Liping; YIN, Mao; YURKOVETSKIY, Aleksandr V.; (397 pag.)WO2019/126691; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics