Category: 75567-84-9

Reference of 75567-84-9,Some common heterocyclic compound, 75567-84-9, name is Methyl 3-(4-bromophenyl)propanoate, molecular formula is C10H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 3-(4-bromophenyl)propanoate (1a) (1.0 g, 4.11 mmol) was dissolved in 7mL ofN,N?-dimethylformamide (DMF). Copper (I) iodide (156 mg, 0.82 mmol),triethylamine (TEA 1.2mL, 8.23mmol), tetrakis (triphenylphosphine) palladium (0)Pd(PPh3)4 475 mg, 0.41 mmol, trimethylsilylacetylene (TMSA 0.74 mL, 5.35mmol) were added and the reaction mixture was stirred at 80 C under Ar until all thestarting material was consumed, as was monitored by TLC. The reaction mixture wasfiltered through a pad of celite and organic solvent (ethyl acetate: n-hexane = 10:1) wasadded. The organic phase was washed two times with saturated ammonium chloride,brine and then dried over magnesium sulfate. The solvent was evaporated to yield theproduct 740 mg and it was used to next without further purification.

The synthetic route of 75567-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ebara, Yasuhito; Hayashi, Tenko; Hori, Sakiko; Kaihatsu, Kunihiro; Kato, Nobuo; Ogata, Katsuya; Okazaki, Miku; Sawada, Shinjiro; Takagi, Kenji; Molecules; vol. 25; 4; (2020);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 75567-84-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75567-84-9, name is Methyl 3-(4-bromophenyl)propanoate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In distinct reactors, 3-(bromophenyl)-propionic methyl esters 16, 17 (1.0 equiv) were dissolved in toluene (7 mL). Phenyl boronic acids 18-21 (2 equiv) in EtOH (3.5 mL) and Na2CO3 2 M (2 M, aq, 3.0 equiv) were then added to the corresponding reactors, and the resulting mixtures were deoxygenated with a stream of N2. After 10 min, Pd(PPh3)4 (0.005 equiv) was added and each mixture was stirred at reflux temperature for 5 h under N2, then cooled to room temperature and treated as follows. Each solution was poured into a mixture of H2O (5 mL) and Et2O (5 mL), and the two phases were separated. The aqueous layer was washed with Et2O (5 mL), and the organic phases were combined and washed with 1 M NaOH (5 mL), followed by brine (5 mL), then dried over Na2SO4 and evaporated. Purification of each crude product performed by flash chromatography on silica gel (petroleum ether/EtOAc = 8/2) yielded the corresponding biphenyl propanoic acid methyl esters 22a-e (Scheme 3).

The chemical industry reduces the impact on the environment during synthesis Methyl 3-(4-bromophenyl)propanoate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Chiriano, Gianpaolo; De Simone, Angela; Mancini, Francesca; Perez, Daniel I.; Cavalli, Andrea; Bolognesi, Maria Laura; Legname, Giuseppe; Martinez, Ana; Andrisano, Vincenza; Carloni, Paolo; Roberti, Marinella; European Journal of Medicinal Chemistry; vol. 48; (2012); p. 206 – 213;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics