Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73792-12-8, name is Ethyl 4-amino-3-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 73792-12-8
Step 1 : Ethyl 3-fluoro-4-hydrazinylbenzoate hydrochloride: To a stirred and cooled (-20C) solution of ethyl 4-amino-3-fluorobenzoate (18 g, 98.809 mmol) in cone. HC1 (200 mL) was added aqueous solution of NaN02 (7.5 g, 108.69 mmol). This mixture was added very slowly to a precooled (-10 C) mixture of and tin chloride (100 g, 444.7 mmol) in cone. HC1 (80 mL) and stirred at the same temperature for 30 min. The precipitate obtained was filtered and washed with diethyl ether (2 x 100 mL) to obtain 19.6 g of the title compound as white solid. 1H NMR (300 MHz, DMSO-i) delta 1.30 (t, J = 7.2 Hz, 3H), 4.27 (q, J = 6.9 Hz, 2H), 7.19 (t, J = 8.1 Hz, 1H), 7.67 (d, J = 8.1 Hz, 1H), 7.78 (d, J = 8.4 Hz, 1H), 8.94 (br s, 1H), 10.50 (br s, 2H); APCI-MS (m/z) 199 (M+H)+.
According to the analysis of related databases, 73792-12-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; DAS, Sanjib; CHAUDHARI, Sachin Sundarlal; THOMAS, Abraham; PARDESHI, Shailesh Ramesh; DESHMUKH, Vishal Govindrao; WADEKAR, Prashant Dilip; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; BAJPAI, Malini; WO2015/87234; (2015); A1;,
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