Category: 7364-20-7

Related Products of 7364-20-7, These common heterocyclic compound, 7364-20-7, name is Methyl 4-ethylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (Diacetoxyiodo)benzene (5 mmol, 1.61 g), I2 (0.4 mmol, 102 mg), p-toluenesulfonamide (0.4 mmol, 68.4 mg), and ethylbenzene (2 mmol, 184 mg) were added to dichloroethane (3 mL). The mixture was warmed at 60 C for 2 h under an argon atmosphere. Then, the mixture was poured into saturated aqueous sodium sulfite solution and extracted with diethyl ether (3 × 20 mL). The organic layer was dried over Na2SO4. After filtration and removal of the solvent under reduced pressure, the residue was subjected to preparative TLC on silica gel using a mixture of hexane and ethyl acetate (5:1) as an eluent to give alpha-(acetoxy)ethylbenzene in 63% yield.

Statistics shows that Methyl 4-ethylbenzoate is playing an increasingly important role. we look forward to future research findings about 7364-20-7.

Reference:
Article; Baba, Haruka; Moriyama, Katsuhiko; Togo, Hideo; Tetrahedron Letters; vol. 52; 33; (2011); p. 4303 – 4307;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 7364-20-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7364-20-7, name is Methyl 4-ethylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Hydrazine hydrate 64% (v/v) (30.0 mL, 0.33 mol) was heated up to 50-60 C. The methyl ester 3 (0.01 mol) was added and the mixture was heated at reflux for 10 min. The cooling was performed sequentially in water bath, followed by ice bath and dry ice-ethanol bath. The precipitate was filtered and washed with cold water.

The chemical industry reduces the impact on the environment during synthesis Methyl 4-ethylbenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Ishii, Marina; Jorge, Salomao Doria; De Oliveira, Alex Alfredo; Palace-Berl, Fanny; Sonehara, Ieda Yuriko; Pasqualoto, Kerly Fernanda Mesquita; Tavares, Leoberto Costa; Bioorganic and Medicinal Chemistry; vol. 19; 21; (2011); p. 6292 – 6301;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7364-20-7, name is Methyl 4-ethylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 7364-20-7

Under nitrogen protection, the1-formic acid methyl-4-ethylbenzene1 t (0.5 mmol), NBS (1.25 mmol) and acetonitrile (2 mL) were added to the reaction tube. Stir at 100 C for 12 hours. After stopping the reaction, cool to room temperature, evaporate the solvent and separate by column chromatography. The volume ratio (mL / mL) of the eluent used is ethyl acetate: petroleum ether = 0: 100 ~ 1: 200.1- (4-formic acid methyl) phenyl-1,2-dibromoethane3t, yield is 83%.

According to the analysis of related databases, 7364-20-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute; Qian Bo; Li Weihe; (12 pag.)CN110862292; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics