Category: 73349-07-2

Perez, Lark J.; Ng, Wai-Leung; Marano, Paul; Brook, Karolina; Bassler, Bonnie L.; Semmelhack, Martin F. published the artcile< Role of the CAI-1 Fatty Acid Tail in the Vibrio cholerae Quorum Sensing Response>, Application of C5H10O3, the main research area is Vibrio quorum sensing CAI1 fatty acid tail preparation antibacterial.

Quorum sensing is a mechanism of chem. communication among bacteria that enables collective behaviors. In V. cholerae, the etiol. agent of the disease cholera, quorum sensing controls group behaviors including virulence factor production and biofilm formation. The major V. cholerae quorum-sensing system consists of the extracellular signal mol. called CAI-1 and its cognate membrane bound receptor called CqsS. Here, the ligand binding activity of CqsS is probed with structural analogs of the natural signal. Enabled by the discovery of a structurally simplified analog of CAI-1, a focused library was prepared and analyzed. The mols. were designed to probe the effects of conformational and structural changes along the length of the fatty acid tail of CAI-1. The results, combined with pharmacophore modeling, suggest a mol. basis for signal mol. recognition and receptor fidelity with respect to the fatty acid tail portion of CAI-1. These efforts provide novel probes to enhance discovery of anti-virulence agents for the treatment of V. cholerae.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Application of C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tokamolthom, Jindarat; Chen, Shui-Tein; Jeyashoke, Narumon; Krisnangkura, Kanit published the artcile< Gas chromatographic separation of R/S-伪-hydroxy fatty acid esters>, Application of C5H10O3, the main research area is hydroxy fatty acid ester enantiomer resolution gas chromatog; wool wax analysis hydroxy fatty acid gas chromatog; pea leaf lipid analysis hydroxy fatty acid gas chromatog.

Gas chromatog. (GC) separations of R/S-伪-hydroxy fatty acids (AHFAs) are carried out on several columns, including 伪-cyclodextrin derivative (Cydex B) chiral column. R/S-AHFAs are well separated on achiral columns (BP 1, nonpolar phase and RTX 2330, very polar phase) as diasteriomeric esters of the optically active alcs., whereas the shorter chain length of the alc. tends to give lower separation factor (伪) on the same column. The longest chain length of alc. used in this study is 2-octanol and its ester shows the highest 伪 on the RTX 2330 capillary column. Thus, the four thermodynamically related column constants (a, b, c and d) of for R- and S-AHFAs standard are determined: ln k’ = a + bn + cT + dnT where k’ is the retention factor, n the equivalent carbon number and T the absolute temperature This equation was used to estimate the equivalent n, and also subsequently used to identify and determine the configuration of AHFAs in wool wax without using a standard AHFA as a reference

Analytica Chimica Acta published new progress about Chromatographic chiral resolution. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Application of C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Xiuru; Wang, Yanhua; Han, Fu-She published the artcile< A thermoregulated phase-separable chiral Pt nanocatalyst for recyclable asymmetric hydrogenation of α-ketoesters>, Computed Properties of 73349-07-2, the main research area is asym hydrogenation ketoester platinum nanocatalyst chiral ionic liquid; cinchonidine polyethylene glycol chiral ionic liquid catalyst asym hydrogenation.

The design and preparation of a chiral Pt nanocatalyst system possessing thermoregulated phase-separation property and its application in recyclable asym. hydrogenation of α-ketoesters are presented. The catalyst was prepared from polyethylene glycol monomethyl ether and cinchonidine.

Chemical Communications (Cambridge, United Kingdom) published new progress about Carboxylic esters Role: RCT (Reactant), RACT (Reactant or Reagent) (α-ketoesters). 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Computed Properties of 73349-07-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Utaka, Masanori; Watabu, Hisashi; Higashi, Hiroshi; Sakai, Takashi; Tsuboi, Sadao; Torii, Sigeru published the artcile< Asymmetric reduction of aliphatic short- to long-chain β-keto acids by use of fermenting bakers' yeast>, COA of Formula: C5H10O3, the main research area is oxoalkanoic acid stereoselective reduction; fatty acid oxo stereoselective reduction; hydroxyalkanoic acid stereoselective preparation.

Me(CH2)nCOCH2CO2H (I, n = 0-4, 7-10, 12, 14) were reduced with fermenting bakers’ yeast to optically active Me(CH2)nCH(OH)CH2CO2H (II) isolated as their Me esters. In all cases, (R)-II acids were obtained in ≥98% enantiomeric excess (ee), except for I (n = 0), which afforded (S)-II (n = 0) in 86% ee. Inhibition of fermentation was observed for I (n = 7), but lowering of the substrate concentration was effective in decreasing the inhibition.

Journal of Organic Chemistry published new progress about Enzymic reduction, stereoselective. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, COA of Formula: C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koenig, Wilfried A.; Icheln, Detlef; Hardt, Ingo published the artcile< Unusual retention behavior of methyl lactate and methyl 2-hydroxybutyrate enantiomers on a modified cyclodextrin>, COA of Formula: C5H10O3, the main research area is methyl lactate enantiomer elution reversal GC; methyl hydroxybutyrate enantiomer elution behavior GC; gas chromatog enantiomer elution behavior; elution reversal enantiomer gas chromatog; cyclodextrin derivative stationary phase gas chromatog; butyryldipentyl cyclodextrin stationary phase gas chromatog; capillary gas chromatog elution reversal enantiomer.

Gas chromatog. elution behavior was investigated for Me lactate and Me 2-hydroxybutyrate enantiomers on a Pyrex capillary column coated with octakis(3-O-butyryl-2,6-di-O-pentyl)-γ cyclodextrin over the complete range of operating temperatures Elution order reversal was achieved for the Me lactate but not for the latter example.

Journal of High Resolution Chromatography published new progress about 73349-07-2. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, COA of Formula: C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koenig, Wilfried A.; Icheln, Detlef; Hardt, Ingo published the artcile< Unusual retention behavior of methyl lactate and methyl 2-hydroxybutyrate enantiomers on a modified cyclodextrin>, COA of Formula: C5H10O3, the main research area is methyl lactate enantiomer elution reversal GC; methyl hydroxybutyrate enantiomer elution behavior GC; gas chromatog enantiomer elution behavior; elution reversal enantiomer gas chromatog; cyclodextrin derivative stationary phase gas chromatog; butyryldipentyl cyclodextrin stationary phase gas chromatog; capillary gas chromatog elution reversal enantiomer.

Gas chromatog. elution behavior was investigated for Me lactate and Me 2-hydroxybutyrate enantiomers on a Pyrex capillary column coated with octakis(3-O-butyryl-2,6-di-O-pentyl)-γ cyclodextrin over the complete range of operating temperatures Elution order reversal was achieved for the Me lactate but not for the latter example.

Journal of High Resolution Chromatography published new progress about 73349-07-2. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, COA of Formula: C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmed, Farjad; Al-Mutairi, Eiman H.; Avery, Kathryn L.; Cullis, Paul M.; Primrose, William U.; Roberts, Gordon C. K.; Willis, Christine L. published the artcile< An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P450 from Bacillus megaterium with potential application in biotransformations>, SDS of cas: 73349-07-2, the main research area is cytochrome P450 hydroxymyristate hydroxylase Bacillus stereochem.

Cytochrome P450 from Bacillus megaterium catalyzes the diastereoselective hydroxylations of 13-hydroxymyristic acid, to predominantly erythro-12,13-dihydroxymyristic acid, of 12-hydroxymyristic acid to give predominantly threo-12,13-dihydroxymyristic acid, in reactions that are stereocomplementary and with considerable potential application in biotransformations.

Chemical Communications (Cambridge) published new progress about Bacillus megaterium. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, SDS of cas: 73349-07-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bekele, Tefsit; Shah, Meha H.; Wolfer, Jamison; Abraham, Ciby J.; Weatherwax, Anthony; Lectka, Thomas published the artcile< Catalytic, Enantioselective [4 + 2]-Cycloadditions of Ketene Enolates and o-Quinones: Efficient Entry to Chiral, α-Oxygenated Carboxylic Acid Derivatives>, Safety of (R)-Methyl 2-hydroxybutanoate, the main research area is cinchona alkaloid catalyst enantioselective cycloaddition quinone ketene enolate.

The authors report catalytic, enantioselective [4 + 2]-cycloadditions of o-quinones with ketene enolates (derived from readily available acid chlorides) using cinchona alkaloid derivatives as catalysts to produce products in high enantiomeric excess (ee) and good to excellent yields. The thermodn. driving force for these reactions is due in part to the restoration of aromaticity to the products. The resulting chiral, bicycloadducts, e.g. I, can be synthetically manipulated in a variety of useful ways, for example to provide a flexible synthesis of α-oxygenated carboxylic acid derivatives

Journal of the American Chemical Society published new progress about [4+2] Cycloaddition reaction. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Safety of (R)-Methyl 2-hydroxybutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bohman, Bjorn; Flematti, Gavin R.; Unelius, C. Rikard published the artcile< Practical one-pot stereospecific preparation of vicinal and 1,3-diols>, Application In Synthesis of 73349-07-2, the main research area is diol stereoselective preparation; hydroxy ester reduction.

A facile one-pot synthesis providing vicinal diols and 1,3-diols in >95% stereoisomeric purity from com. available enantiopure hydroxy esters has been developed. The esters were reduced with DIBALH and alkylated in situ with 4-pentenylmagnesium bromide, which after workup generated the title diols as diastereomeric pairs. These pairs were easily separated by preparative chromatog., affording products with retained stereoisomeric purity from the starting materials. This method represents an expedient preparation of many common natural products, such as cerambycid beetle pheromones and intermediates towards bicyclic acetal bark beetle pheromones.

Tetrahedron Letters published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Application In Synthesis of 73349-07-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bohman, Bjorn; Flematti, Gavin R.; Unelius, C. Rikard published the artcile< Practical one-pot stereospecific preparation of vicinal and 1,3-diols>, Application In Synthesis of 73349-07-2, the main research area is diol stereoselective preparation; hydroxy ester reduction.

A facile one-pot synthesis providing vicinal diols and 1,3-diols in >95% stereoisomeric purity from com. available enantiopure hydroxy esters has been developed. The esters were reduced with DIBALH and alkylated in situ with 4-pentenylmagnesium bromide, which after workup generated the title diols as diastereomeric pairs. These pairs were easily separated by preparative chromatog., affording products with retained stereoisomeric purity from the starting materials. This method represents an expedient preparation of many common natural products, such as cerambycid beetle pheromones and intermediates towards bicyclic acetal bark beetle pheromones.

Tetrahedron Letters published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Application In Synthesis of 73349-07-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics