Category: 721-63-1

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 721-63-1 as follows. Product Details of 721-63-1

General procedure: To a stirred solution of phenyl acetic acid ethyl ester 1a (1 g, 6.09 mmol) in THF (10 mL) was added LiHMDS (9.1 ml, 1 M sol. in THF, 7.31 mmol) at -78 C and the reaction mixture was stirred at this temperature for 30 min. Ethyl-1-imidazole carboxylate 2 (1.2 g, 9.146 mmol) in dry THF (3 ml) was added drop wise to the reaction mixture at -78 C and stirred at rt for 3 h. The reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The combined organic layer was washed with water, saturated brine solution, and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product was chromatographed on a silica gel column. Elution with 4% ethyl acetate/pet ether gave the pure compound 3a (1.1 g, 81% yield) as a colorless liquid.

According to the analysis of related databases, 721-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Behera, Manoranjan; Venkat Ragavan; Sambaiah; Erugu, Balaiah; Rama Krishna Reddy; Mukkanti; Yennam, Satyanarayana; Tetrahedron Letters; vol. 53; 9; (2012); p. 1060 – 1062;,
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Electric Literature of 721-63-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 721-63-1 as follows.

General procedure: Arylacetate(0.05mol) was dissolved in dry THF or toluene, and stirred in the ice bath.Sodium (0.075mol) was added to the solution, the mixture was stirred for 30 minin the ice bath. Ethyl formate (0.1mol) was added by dropwise to the above solution,the temperature of the reaction mixture was maintained at < 5 C.After the addition, the reaction mixture was stirred for another 2 h, thenwarmed to room temperature and stirred overnight (about 15 h). Water (50mL) wasadded to the slurry mixture, and stirred for an additional 30 min, thenportioned between organic layer and water. Water layer was extracted withdichloromethane (2×50mL). These extracts were discarded. The aqueous phase wasacidified with acetic acid or 5% hydrochloric acid, and extracted withdichloromethane (3×50mL). This extract was washed with water and brine, driedover anhydrous sodium sulfate, and the solvent was removed by rotaryevaporation under reduced pressure to give thick yellow oil, which was purifiedby column chromatography with ethyl acetate in petroleum ether. According to the analysis of related databases, 721-63-1, the application of this compound in the production field has become more and more popular. Reference:
Article; Liu, Jinbing; Chen, Changhong; Wu, Fengyan; Tang, Junyuan; Bioorganic and Medicinal Chemistry Letters; vol. 26; 7; (2016); p. 1715 – 1719;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 721-63-1 as follows. Computed Properties of C11H11F3O2

General procedure: To a stirred solution of phenyl acetic acid ethyl ester 1a (1 g, 6.09 mmol) in THF (10 mL) was added LiHMDS (9.1 ml, 1 M sol. in THF, 7.31 mmol) at -78 C and the reaction mixture was stirred at this temperature for 30 min. Ethyl-1-imidazole carboxylate 2 (1.2 g, 9.146 mmol) in dry THF (3 ml) was added drop wise to the reaction mixture at -78 C and stirred at rt for 3 h. The reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The combined organic layer was washed with water, saturated brine solution, and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product was chromatographed on a silica gel column. Elution with 4% ethyl acetate/pet ether gave the pure compound 3a (1.1 g, 81% yield) as a colorless liquid.

According to the analysis of related databases, 721-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Behera, Manoranjan; Venkat Ragavan; Sambaiah; Erugu, Balaiah; Rama Krishna Reddy; Mukkanti; Yennam, Satyanarayana; Tetrahedron Letters; vol. 53; 9; (2012); p. 1060 – 1062;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 721-63-1 as follows. SDS of cas: 721-63-1

A 100 mL two-necked reaction flask was placed in an ice bath at 0 C, p-trifluoromethylphenylacetate 2i (10.0 mmol) and 20 mL of acetonitrile were added, and p-toluenesulfonyl azide 3a (11.0 mmol) was added.1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (15.0 mmol) was slowly added.Stir for 5 minutes in an ice bath and place in a microwave reactor.Set power 400W, heating temperature 40 C, heating time 60 min,Turn on the exhaust fan.After the reaction is completed, the mixture is cooled to room temperature, quenched by the addition of ammonium chloride solution, and extracted with dichloromethane and water. The organic phase is collected, dried over anhydrous sodium sulfate, filtered, and evaporated. Chromatography (eluent is petroleum ether (60-90 C) / ethyl acetate, v / v = 80:1),The red solid target product 1i (2.06 g, yield 80%) was obtained.The target product was confirmed by nuclear magnetic resonance spectroscopy and high resolution mass spectrometry.

According to the analysis of related databases, 721-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nanjing Tech University; Gao Zhen; Yi Xiangyan; Huang Fei; Huang He; Yu Yang; Zhang Zhipeng; Xue Lian; Wang Lize; Qiao Nasen; (12 pag.)CN108727216; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 721-63-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 721-63-1 as follows.

Step B: Ethyl 2-bromo-2-(4-(trifluoromethyl)phenyl)acetate To a solution of ethyl 2-(4-(trifluoromethyl)phenyl)acetate (5 g, 21.5 mmol) in CC14 (100 mL) was added NBS (11.5 g, 64.6 mmol). The resulting mixture was heated to reflux and stirred for 16 hr. The reaction mixture was then filtered and the filtrate was evaporated to dryness. The residue was purified via CombiFlash (80 g column, DCM in Petroleum ether from 0% to 30%) to give ethyl 2-bromo-2-(4-(trifluoromethyl)phenyl)acetate as an oil. NMR (CDC13, 400 MHz): 5 7.68 (d, J= 8.0 Hz, 2H), 7.63 (d, J= 8.0 Hz, 2H), 5.35 (s, 1H), 4.33-4.18 (m, 2H), 1.30 (t, J = 7.0 Hz, 3H).

According to the analysis of related databases, 721-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; CAI, Jiaqiang; CRESPO, Alejandro; DU, Xiaoxing; DUBOIS, Byron Gabriel; GUIADEEN, Deodialsingh; KOTHANDARAMAN, Shankaran; LIU, Ping; LIU, Rongqiang; QUAN, Weiguo; SINZ, Christopher; WANG, Liping; (285 pag.)WO2016/49099; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics