Category: 7126-50-3

Abell, Andrew D.; Martyn, Derek C.; May, Barnaby C. H.; Nabbs, Brent K. published the artcile< An amino acid N-derivatising group that can be colored on demand>, Reference of 7126-50-3, the main research area is colored red amino acid pyrrolizinone solution solid phase synthesis; amino acid formylpyrrolecarboxylic cinnamoyl chloride; peptide pyrrolizinone preparation red colored.

A method is presented whereby an amino acid is reacted with 5-formyl-1H-pyrrole-2-carboxylic acid to give an N-derivatized tag that has a latent ability to be colored. A characteristic red pyrrolizin-3-one (colored tag) is then revealed on treatment with hydrocinnamoyl chloride. This sequence has been carried out on amino acids in solution, and on solid phase, and also on dipeptides.

Tetrahedron Letters published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Reference of 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Duan, Guiyun; Liu, Hao; Zhang, Liqing; Yuan, Chunhao; Li, Yongchao; Ge, Yanqing published the artcile< Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the SN2 substitution/condensation/tautomerization cascade process>, Category: esters-buliding-blocks, the main research area is indolizine preparation; imidazopyridine preparation; pyrrole carbaldehyde acetoacetic ester substitution condensation tautomerization cascade.

A simple and efficient cascade reaction was developed for the construction of hydroxy substituted indolizines I [R1 = CHO, COMe, I, etc.; R2 = H, COOMe, Cl, etc.] and imidazopyridines II [R3 = H, Me; R4 = Me, Et] from pyrrole-2-carbaldehydes and com. available 4-halogenated acetoacetic esters. Their optical properties were also evaluated.

RSC Advances published new progress about Condensation reaction. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wimmer, Eric; Borghese, Sophie; Blanc, Aurelien; Beneteau, Valerie; Pale, Patrick published the artcile< Zeolite-Based Organic Synthesis (ZeoBOS) of Acortatarin A: First Total Synthesis Based on Native and Metal-Doped Zeolite-Catalyzed Steps>, Reference of 7126-50-3, the main research area is acortatarin A total synthesis zeolite organic synthesis; spiroketalization silver zeolite catalyst total synthesis acortatarin A; cross coupling copper zeolite catalyst total synthesis acortatarin A; copper; doped-zeolite; silver; spiroketalization; ynamide formation.

Similarly to polymer-supported assisted synthesis (PSAS), organic synthesis could be envisaged being performed by using zeolites, native or metal-doped, as heterogeneous catalysts. To illustrate this unprecedented Zeolite-Based Organic Synthesis (ZeoBOS), the total synthesis of acortatarin A (I) was achieved through a novel strategy and using five out of eleven synthetic steps catalyzed by H- or metal-doped zeolites as catalysts. Notably, the formation of an yne-pyrrole intermediate with a copper-doped zeolite and the spiroketalization of an alkyne diol with a silver-doped zeolite have been developed as key steps of the synthesis.

Chemistry – A European Journal published new progress about Cross-coupling reaction. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Reference of 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wimmer, Eric; Borghese, Sophie; Blanc, Aurelien; Beneteau, Valerie; Pale, Patrick published the artcile< Zeolite-Based Organic Synthesis (ZeoBOS) of Acortatarin A: First Total Synthesis Based on Native and Metal-Doped Zeolite-Catalyzed Steps>, Reference of 7126-50-3, the main research area is acortatarin A total synthesis zeolite organic synthesis; spiroketalization silver zeolite catalyst total synthesis acortatarin A; cross coupling copper zeolite catalyst total synthesis acortatarin A; copper; doped-zeolite; silver; spiroketalization; ynamide formation.

Similarly to polymer-supported assisted synthesis (PSAS), organic synthesis could be envisaged being performed by using zeolites, native or metal-doped, as heterogeneous catalysts. To illustrate this unprecedented Zeolite-Based Organic Synthesis (ZeoBOS), the total synthesis of acortatarin A (I) was achieved through a novel strategy and using five out of eleven synthetic steps catalyzed by H- or metal-doped zeolites as catalysts. Notably, the formation of an yne-pyrrole intermediate with a copper-doped zeolite and the spiroketalization of an alkyne diol with a silver-doped zeolite have been developed as key steps of the synthesis.

Chemistry – A European Journal published new progress about Cross-coupling reaction. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Reference of 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Warashina, Takuya; Matsuura, Daisuke; Sengoku, Tetsuya; Takahashi, Masaki; Yoda, Hidemi; Kimura, Yoshikazu published the artcile< Regioselective Formylation of Pyrrole-2-Carboxylate: Crystalline Vilsmeier Reagent vs Dichloromethyl Alkyl Ether>, SDS of cas: 7126-50-3, the main research area is regioselective formylation pyrrolecarboxylate; crystalline Vilsmeier reagent dichloromethyl alkyl ether preparation; formyl pyrrolecarboxylate preparation.

New preparations of crystalline Vilsmeier reagent (VR) and dichloromethyl Pr or Bu ether were developed. The methods are environmentally benign and applicable to large-scale synthesis. Formylations of 1H-pyrrole-2-carboxylates were achieved with these reagents, regioselectively affording the 4-formyl and 5-formyl derivatives in nearly quant. yields.

Organic Process Research & Development published new progress about Ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (dichloromethyl alkyl). 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, SDS of cas: 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, DaWon; Lee, Jeong Hwa; Kim, Hye Yun; Shin, Jisu; Kim, Kyeonghwan; Lee, Sejin; Park, Jinwoo; Kim, JinIkyon; Kim, YoungSoo published the artcile< Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model>, Application of C8H9NO3, the main research area is alzheimer disease brain amyloid beta.

Alzheimer disease (AD) is a neurodegenerative disorder characterized by the aberrant production and accumulation of amyloid-β (Aβ) peptides in the brain. Accumulated Aβ in soluble oligomer and insoluble plaque forms are considered to be a pathol. culprit and biomarker of the disorder. Here, we report a fluorescent universal Aβ-indicator YI-13, 5-(4-fluorobenzoyl)-7,8-dihydropyrrolo[1,2-b]isoquinolin-9(6H)-one, which detects Aβ monomers, dimers, and plaques. We synthesized a library of 26 fluorescence chems. with the indolizine core and screen them through a series of in vitro tests utilizing Aβ as a target and YI-13 was selected as the final imaging candidate. YI-13 was found to stain and visualize insoluble Aβ plaques in the brain tissue, of a transgenic mouse model with five familial AD mutations (5XFAD), by a histochem. approach and to label soluble Aβ oligomers within brain lysates of the mouse model under a fluorescence plate reader. Among oligomers aggregated from monomers and synthetic dimers from chem. conjugated monomers, YI-13 preferred the dimeric Aβ.

PLoS One published new progress about Alzheimer disease. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Application of C8H9NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Laha, Joydev K.; Sharma, Shubhra; Kirar, Seema; Banerjee, Uttam C. published the artcile< Design, Sustainable Synthesis, and Programmed Reactions of Templated N-Heteroaryl-Fused Vinyl Sultams>, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is heteroarylfused vinyl sultam preparation Michael addition hydrogenation cycloaddition.

A de novo design and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chem. reactions on vinyl sultam periphery or (hetero)aryl ring is described. The key features include rational designing and sustainable synthesis of the template, customized reactions of vinyl sultams at C=C bond or involving N-S bond cleavage, and reactions on the periphery of the heteroaryl ring for late-stage diversification. The simple, easy access to the template coupled with opportunities for the synthesis of diversely functionalized heterocyles from a single template constitutes a rare study in contemporary organic synthesis.

Journal of Organic Chemistry published new progress about Cycloaddition reaction. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lo, Ho Yin; Bentzien, Jorg; White, Andre; Man, Chuk C.; Fleck, Roman W.; Pullen, Steven S.; Khine, Hnin Hnin; King, Josephine; Woska, Joseph R. Jr.; Wolak, John P.; Kashem, Mohammed A.; Roth, Gregory P.; Takahashi, Hidenori published the artcile< 2-Aminobenzimidazoles as potent ITK antagonists: de novo design of a pyrrole system targeting additional hydrogen bonding interaction>, SDS of cas: 7126-50-3, the main research area is aminobenzimidazole derivative preparation ITK antagonist.

Based on information from mol. modeling, a series of 2-aminobenzimidazoles with pyrrole moieties were designed and synthesized as ITK antagonists. Results showed that a significant improvement of intrinsic and cell-based potency was achieved. X-ray crystallog. anal. of an inhibitor complex with ITK confirmed the prediction from the de novo design that the pyrrole moiety of the inhibitor would form an addnl. hydrogen bonding interaction with Glu436 in the catalytic domain, and hence improve overall binding affinity of the inhibitor.

Tetrahedron Letters published new progress about Anti-inflammatory agents. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, SDS of cas: 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khan, M. K. A.; Morgan, K. J.; Morrey, D. P. published the artcile< Carbonyl derivatives of heterocyclic compounds. III. The preparation of 3-acylpyrroles>, SDS of cas: 7126-50-3, the main research area is .

Synthetic routes to 3-acylpyrroles by methods involving ring closure, transformation of substituents, and further substitution of monosubstituted pyrroles were investigated. The condensation of H2NCHCHO with acylpyruvates appears to provide a general route to the 3-ketones. The related condensation of N-carbethoxyglycine ester and nitrile gave poor yields of 3-cyanopyrrole but attempts to obtain the 3-Ac derivative by the use of MeCOCH:CH2 showed the occurrence of an alternative reaction path and gave no useful product. Attempts to convert 3-cyano- and 3-carboxypyrroles into acyl derivatives by the action of nucleophilic reagents were not successful. Pyrrole-3-carboxaldehyde was obtained by decarboxylation of the minor formylation product of Et pyrrole-2-carboxylate. 24 references.

Tetrahedron published new progress about Carbonyl compounds (organic). 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, SDS of cas: 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wallace, David M.; Leung, Sam H.; Senge, Mathias O.; Smith, Kevin M. published the artcile< Rational tetraarylporphyrin syntheses: tetraarylporphyrins from the MacDonald route>, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is tetraarylporphyrin; porphyrin tetraaryl; condensation MacDonald tetraarylporphyrin.

Four new synthetic routes to meso-tetraarylporphyrins using a MacDonald-type [2 + 2] condensation are described. Self-condensation of a 5-aryldipyrromethane, e.g., 5-(4-tolyl)dipyrromethane, with an aryl-substituted one-carbon bridging unit affords a mixture of tetraarylporphyrins due to acid-catalyzed redistribution reactions. The second and third methods presented here show wide applicability for the preparation of 5,10,15,20-tetraaryl-substituted porphyrins, e.g., I, with 2-fold rotational symmetry and involves self-condensation of 5-aryl-1-aryldipyrromethanecarbinols, e.g., II. Finally, the 4th approach involves a [2 + 2] approach in which one of the 2 dipyrromethanes bears both of the bridging carbons in the porphyrin products, affording a porphyrin which possesses 3 different aryl rings, with one pair of uniquely opposite identical aryl groups. The last two [2 + 2] methods are further extended to give a tetraarylporphyrin bearing four different aryl groups in a predesignated array, the structure of which is confirmed by a single-crystal X-ray study.

Journal of Organic Chemistry published new progress about Condensation reaction. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics