Category: 71195-85-2

Eberhardt, Marc; Mruk, Ralf; Zentel, Rudolf; Theato, Patrick published the artcile< Synthesis of pentafluorophenyl (meth)acrylate polymers: New precursor polymers for the synthesis of multifunctional materials>, COA of Formula: C9H3F5O2, the main research area is pentafluorophenyl acrylate methacrylate polymerization amine alc reactivity multifunctional polymer.

Pentafluorophenyl acrylate and -methacrylate were polymerized using AIBN as a thermal initiator. The obtained polymers were soluble polymeric active esters that could be used for the preparation of multifunctional polymers. The reactivity of poly(pentafluorophenyl acrylate) and poly(pentafluorophenyl methacrylate) towards primary and secondary amines, as well as alcs. was investigated in a quant. way. Both poly(active esters) reacted satisfactorily with aliphatic primary and secondary amines but only low conversion was found in the case of aromatic amines. Conversions of only 30% were reached when poly(pentafluorophenyl acrylate) was treated with one equivalent of alc. under base catalysis. In time resolved FT-IR studies the rate constants of the polymer analogous reactions were determined

European Polymer Journal published new progress about Fluoropolymers Role: SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yang; Beija, Mariana; Laurent, Sophie; vander Elst, Luce; Muller, Robert N.; Duong, Hien T. T.; Lowe, Andrew B.; Davis, Thomas P.; Boyer, Cyrille published the artcile< Macromolecular Ligands for Gadolinium MRI Contrast Agents>, Application In Synthesis of 71195-85-2, the main research area is fluoropolymer gadolinium MRI contrast agent preparation.

Macromol. ligands for gadolinium contrast agents (CAs) were prepared via a grafting to strategy. Copolymers of oligoethylene glycol Me ether acrylate (OEGA) and an activated ester monomer, pentafluorophenyl acrylate (PFPA), were synthesized and modified with the 1-(5-amino-3-aza-2-oxypentyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO3A-tBu-NH2) chelate for the complexation of Gd3+. The relaxivity properties of the ligated Gd3+ agents were then studied to evaluate the effect of macromol. architecture on their behavior as magnetic resonance imaging (MRI) CAs. Ligands made from linear and hyperbranched macromols. showed a substantially increased relaxivity in comparison to existing com. Gd3+ MRI contrast agents. In contrast, star nanogel polymers exhibited a slightly lower relaxivity per Gd3+ ion (but still substantially higher relaxivity than existing low mol. weight com. CAs). This work shows that macromol. ligands have the potential to serve as components of Gd MRI agents as there are enhanced effects on relaxivity, allowing for lower Gd concentrations to achieve contrast, while potentially imparting control over pharmacokinetics.

Macromolecules (Washington, DC, United States) published new progress about Cytotoxicity. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application In Synthesis of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dao, Nam V.; Ercole, Francesca; Li, Yuhuan; Davis, Thomas P.; Kaminskas, Lisa M.; Sloan, Erica K.; Quinn, John F.; Whittaker, Michael R. published the artcile< Nitroxide-functional PEGylated nanostars arrest cellular oxidative stress and exhibit preferential accumulation in co-cultured breast cancer cells>, Reference of 71195-85-2, the main research area is human breast cancer oxidative stress nitroxide; polyethylene glycol nanostar ROS anticancer.

The limited application of traditional antioxidants to reducing elevated levels of reactive oxygen species (ROS) is potentially due to their lack of stability and biocompatibility when tested in a biol. milieu. For instance, the poor biol. antioxidant performance of small mol. nitroxides arises from their limited diffusion across cell membranes and their significant side effects when applied at high doses. Herein, we describe the use of nanostructured carriers to improve the antioxidant activity of a typical nitroxide derivative, (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). Polymers with star-shaped structures were synthesized and were further conjugated to TEMPO moieties via amide linkages. The TEMPO-loaded stars have small hydrodynamic sizes (<20 nm), and are better tolerated by cells than free TEMPO in a breast cancer-fibroblast co-culture, a system exhibiting elevated ROS levels. At a well-tolerated concentration, the polymer with the highest TEMPO-loading capacity successfully downregulated ROS production in co-cultured cells (a significant decrease of up to 50% vs. basal ROS levels), which was accompanied by a specific reduction in superoxide anion generation in the mitochondria. In contrast, the equivalent concentration of free TEMPO did not achieve the same outcome. Further investigation showed that the TEMPO-conjugated star polymers can be recycled inside the cells, thus providing longer term scavenging activity. Cell association studies demonstrated that the polymers can be taken up by both cell types in the co-culture, and are found to co-locate with the mitochondria. Interestingly the stars exhibited preferential mitochodria targeting in the co-cultured cancer cells compared to accompanying fibroblasts. The data suggest the potential of TEMPO-conjugated star polymers to arrest oxidative stress for various applications in cancer therapy. Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Animal tissue coculture. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

zur Borg, Lisa; Domanski, Anna L.; Berger, Ruediger; Zentel, Rudolf published the artcile< Photoinduced Charge Separation of Self-Organized Semiconducting Superstructures Composed of a Functional Polymer-TiO2 Hybrid>, Computed Properties of 71195-85-2, the main research area is polyphenylenevinylene acrylic diblock copolymer titanium dioxide gel charge separation.

The incorporation of TiO2 nanoparticles into long (several micrometers) fibers of a gel-forming poly(para-phenylene vinylene) (PPV) derivative is described. For that purpose, a PPV-block-dopamine polymer is synthesized, which is used to coat TiO2 nanoparticles leading to well-dispersed nanoparticles and fluorescence quenching of the polymer. Independently, the homopolymer gels in various organic solvents are observed to form long fibers. By mixing the PPV homopolymer with the TiO2-PPV hybrid, we are able to incorporate the nanoparticles into the fibrous network, as shown in transmission electron microscopy (TEM) images. Photoinduced charge separation is measured by Kelvin probe force microscopy. Upon illuminating the polymer fibers, pos. charges are observed, even at distances of around 300 nm. From these results, charge transport along the polymer fibers is inferred.

Macromolecular Chemistry and Physics published new progress about Gels, thermally reversible. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Computed Properties of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Jaemin; Nam, Jiyun; Seo, Myungeun; Li, Sheng published the artcile< Side-Chain Density Driven Morphology Transition in Brush-Linear Diblock Copolymers>, Electric Literature of 71195-85-2, the main research area is side chain density morphol transition brush linear diblock copolymer.

We report the synthesis and self-assembly of brush-linear diblock copolymers with variable side-chain length and d. Poly(pentafluorophenyl acrylate-g-ethylene glycol)-b-polystyrene ((PPFPA-g-PEG)-b-PS) brush-linear diblock copolymers are prepared by sequential reversible addition-fragmentation chain transfer (RAFT) polymerization of PPFPA and PS, followed by postpolymn. reaction between the precursor PPFPA-b-PS diblock copolymer and amine-functionalized PEG. By controlling the PEG chain length and the degree of substitution, brush-linear diblock copolymers with different side-chain lengths and densities are obtained. The solid-state morphologies of the diblocks are then examined by small-angle X-ray scattering (SAXS). At low PEG side-chain d., the segregation of PEG and PS away from PPFPA leads to the formation of PEG and PS lamellar domains with PPFPA in the interface. At high PEG side-chain d., the segregation is between the PPFPA-g-PEG brush block and the PS linear block, and the domain morphol. is determined by the composition of the brush block. A partial exptl. phase diagram is presented, and it illustrates the importance of both side-chain length and d. on the microdomain morphol. of brush-linear diblock copolymers.

ACS Macro Letters published new progress about Acrylic polymers, fluorine-containing, block, diblock Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Oschmann, Bernd; Bresser, Dominic; Tahir, Muhammad Nawaz; Fischer, Karl; Tremel, Wolfgang; Passerini, Stefano; Zentel, Rudolf published the artcile< Polyacrylonitrile Block Copolymers for the Preparation of a Thin Carbon Coating Around TiO2 Nanorods for Advanced Lithium-Ion Batteries>, Safety of Perfluorophenyl acrylate, the main research area is polyacrylonitrile block copolymer carbon coating titania nanorod lithium battery; RAFT-polymerization; TiO2 nanorods; carbon coating; lithium-ion batteries; poly­acrylonitrile.

Herein, a new method for the realization of a thin and homogeneous carbonaceous particle coating, made by carbonizing RAFT polymerization derived block copolymers anchored on anatase TiO2 nanorods, is presented. These block copolymers consist of a short anchor block (based on dopamine) and a long, easily graphitizable block of polyacrylonitrile. The grafting of such block copolymers to TiO2 nanorods creates a polymer shell, which can be visualized by at. force microscopy (AFM). Thermal treatment at 700° converts the polyacrylonitrile block to partially graphitic structures (as determined by Raman spectroscopy), establishing a thin carbon coating (as determined by transmission electron microscopy, TEM, anal.). The carbon-coated TiO2 nanorods show improved electrochem. performance in terms of achievable specific capacity and, particularly, long-term cycling stability by reducing the average capacity fading per cycle from 0.252 mAh g-1 to only 0.075 mAh g-1.

Macromolecular Rapid Communications published new progress about Annealing (of polyacrylonitrile block). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Safety of Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Arnold, Rachelle M.; Sheppard, Gareth R.; Locklin, Jason published the artcile< Comparative Aminolysis Kinetics of Different Active Ester Polymer Brush Platforms in Postpolymerization Modification with Primary and Aromatic Amines>, COA of Formula: C9H3F5O2, the main research area is aminolysis kinetics active ester polymer brush postpolymn modification.

The kinetics of aminolysis between two different active ester polymer brush platforms, poly(4-pentafluorophenyl acrylate) (poly(PFPA)) and poly(N-hydroxysuccinimide-4-vinyl benzoate) (poly(NHS4VB)), are compared using primary and aromatic amines with varying reactivity toward postpolymn. modification. UV-vis was used to monitor the aminolysis of both brush platforms with 1-aminomethylpyrene (AMP), 1-aminopyrene (AP), and Ru(bpy)2(phen-5-NH2)(PF6) (Ru2+A). Using a pseudo-first-order kinetics model, the pseudo-first-order rate constant (k’) was calculated for each system. The k’ of poly(PFPA) modified with AMP, AP, and Ru2+A were 2.46 × 10-1, 5.11 × 10-3, and 2.59 × 10-3 s-1, resp., while poly(NHS4VB) can only be functionalized with the alkyl amine, albeit at a slower rate constant, k’ of 3.49 × 10-3 s-1, compared to that of poly(PFPA) with AMP. The kinetics of surface-initiated photopolymerization of PFPA from oxide surfaces was also studied as an effective method to control grafting d. and film thickness.

Macromolecules (Washington, DC, United States) published new progress about Aminolysis kinetics. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Bin; Thayumanavan, S. published the artcile< Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels>, Recommanded Product: Perfluorophenyl acrylate, the main research area is pH sensitivity acetal ketal encapsulation stability polymeric nanogel.

The effect of structural variations in acetal- and ketal-based linkers upon their degradation kinetics is studied through the design, synthesis, and study of six series of mols., comprising a total of 18 different mols. Through this systematic study, the structural fine-tuning of the linkers allows access to variations in kinetics of degradation of >6 orders of magnitude. Hammett correlations show that the ρ value for the hydrolysis of benzylidene acetals is ∼-4.06, which is comparable to an SN1-like process. There is a strong, developing pos. charge at the benzylic position in the transition state during the degradation of acetals. This pos. charged transition state is consistent with the relative degradation rates of acetals vs. ketals (correlated to stabilities of 1°, 2°, and 3° carboxonium ion type intermediates) and the observed effect of proximal electron-withdrawing groups upon the degradation rates. Following this, the authors studied whether the degradation kinetics study correlates with pH-sensitive variations in the host-guest characteristics of polymeric nanogels that contains these acetal or ketal moieties as crosslinking functionalities. Indeed, the trends observed in the small mol. degradation have clear correlations with the encapsulation stability of guest mols. within these polymeric nanogels. The implications of this fundamental study extend to a broad range of applications, well beyond the polymeric nanogel examples studied here.

Journal of the American Chemical Society published new progress about Acetals Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Van Driessche, Alexandra; Kocere, Agnese; Everaert, Hannelien; Nuhn, Lutz; Van Herck, Simon; Griffiths, Gareth; Fenaroli, Federico; De Geest, Bruno G. published the artcile< pH-Sensitive Hydrazone-Linked Doxorubicin Nanogels via Polymeric-Activated Ester Scaffolds: Synthesis, Assembly, and In Vitro and In Vivo Evaluation in Tumor-Bearing Zebrafish>, Formula: C9H3F5O2, the main research area is doxorubicin nanogel antitumor hydrazone tumor.

Nanoparticle conjugation is a powerful method to reduce the side effects of anticancer agents such as doxorubicin by altering the pharmacokinetic profile of the drug. Nanoparticles can prolong the circulation time and could also promote enhanced accumulation in tumors, either passively via the enhanced permeability and retention effect or actively when decorated with targeting motifs. For the particular case of doxorubicin, the hydrazone-based conjugation chem. is popular but commonly involves laborious chem. transformation steps. Here, we report on a straightforward route for the synthesis of hydrazone-based doxorubicin-polymer conjugates starting from a polymeric-activated ester scaffold onto which doxorubicin-reactive hydrazide moieties are introduced by simple treatment with hydrazine. Using block copolymers composed of a hydrophobic reactive ester block, we demonstrate a simple route to assemble core-crosslinked doxorubicin-loaded nanoparticles. The latter largely retain their bioactivity in vitro. In a zebrafish embryo “”premurine”” in vivo model, we demonstrate a drastic reduction in the systemic toxicity of doxorubicin upon nanoparticle conjugation and also demonstrate enhanced tumor accumulation and tumor growth reduction

Chemistry of Materials published new progress about Antitumor agents. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Woodfield, Peter A.; Zhu, Yicheng; Pei, Yiwen; Roth, Peter J. published the artcile< Hydrophobically Modified Sulfobetaine Copolymers with Tunable Aqueous UCST through Postpolymerization Modification of Poly(pentafluorophenyl acrylate)>, SDS of cas: 71195-85-2, the main research area is hydrophobic pendant sulfobetaine copolymer postpolymn modification aqueous solution UCST.

Polysulfobetaines, polymers carrying highly polar zwitterionic side chains, present a promising research field by virtue of their antifouling properties, hemocompatibility, and stimulus-responsive behavior. However, limited synthetic approaches exist to produce sulfobetaine copolymers comprising hydrophobic components. Postpolymn. modification of an activated ester precursor, poly-(pentafluorophenyl acrylate), employing a zwitterionic amine, 3-((3-aminopropyl)-dimethylammonio)-propane-1-sulfonate, ADPS, is presented as a novel, 1-step synthetic concept toward sulfobetaine (co)-polymers. Modifications were performed in homogeneous solution using propylene carbonate as solvent with mixtures of ADPS and pentylamine, benzylamine, and dodecylamine producing well-defined statistical acrylamido sulfobetaine copolymers containing hydrophobic pentyl, benzyl, or dodecylacrylamide comonomers with well-controllable molar composition as evidenced by NMR and FTIR spectroscopy and size exclusion chromatog. This synthetic strategy was exploited to study, for the first time, the influence of hydrophobic modification on the upper critical solution temperature (UCST) of sulfobetaine copolymers in aqueous solution Surprisingly, incorporation of pentyl groups increases solubility over a wide composition range, whereas benzyl groups decreased solubility, an effect attributed to different entropic and enthalpic contributions of both functional groups. While UCST transitions of polysulfobetaines are typically limited to higher molar mass samples, incorporation of 0-65 mol.% of benzyl groups into copolymers with molar masses 25.5-34.5 kg/mol enabled sharp, reversible transitions 6-82° in solutions containing ≤76 mM NaCl, as observed by optical transmittance and dynamic light scattering. Both synthesis and systematic UCST increase of sulfobetaine copolymers presented here are expected to expand the scope and applicability of these smart materials.

Macromolecules (Washington, DC, United States) published new progress about Cloud point. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, SDS of cas: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics