Category: 707-07-3

On January 30, 2014, Peng, Peng; Xiong, De-Cai; Ye, Xin-Shan published an article.Safety of (Trimethoxymethyl)benzene The title of the article was ortho-Methylphenylthioglycosides as glycosyl building blocks for preactivation-based oligosaccharide synthesis. And the article contained the following:

Thioglycosides are widely used in orthogonal glycosylation, armed-disarmed chemoselective glycosylation, and preactivation-based glycosylation. Nevertheless, aglycon transfer occasionally occurred in the glycosylation process of thioglycosides. This problem was also encountered in preactivation-based reactions, which limited the applications of preactivation-based glycosylation to some extent. To tackle this problem, sterically hindered aglycon ortho-methylphenylthioglycosides were introduced as glycosyl building blocks. These thioglycosides prevented the aglycon transfer and enhanced the efficiency of glycosyl coupling reactions, especially in the reactions of disarmed donors with armed acceptors. Moreover, these thioglycosides were employed in preactivation-based one-pot oligosaccharide assembly. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Safety of (Trimethoxymethyl)benzene

The Article related to ortho methylphenylthioglycoside synthesis preactivation glycosylation oligosaccharide, aglycon transfer, glycosylation, oligosaccharide, preactivation, o-methylphenylthioglycoside and other aspects.Safety of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Ruixue; Zhan, Miao; Peng, Lingling; Pang, Xuehai; Yang, Jun; Zhang, Tao; Jiang, Hongxia; Zhao, Lifeng; Chen, Yuanwei published an article in 2015, the title of the article was Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties.Safety of (Trimethoxymethyl)benzene And the article contains the following content:

Nintedanib is a novel triple angiokinase inhibitor that inhibits three growth factors simultaneously. Deuterated derivatives of nintedanib I (R1 = CH3, CD3; R2 = CH3, CD3) at certain metabolically active sites were prepared and evaluated in vitro and in vivo. In particular, deuterated compound I (R1 = CH3; R2 = CD3) had significantly improved pharmacokinetic properties compared with nintedanib. These efforts lay the foundation for further investigating the druggability of I (R1 = CH3; R2 = CD3). The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Safety of (Trimethoxymethyl)benzene

The Article related to deuterated nintedanib preparation human antitumor angiokinase inhibitor pharmacokinetic property, nintedanib, antitumor activity, deuterium isotope effect, triple angiokinase inhibitor and other aspects.Safety of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xin; Wang, Dongyue; Jin, Guoxia; Wang, Lizhen; Guo, Zhongwu; Gu, Guofeng published an article in 2017, the title of the article was Synthesis of a tetrasaccharide repeating unit of the exopolysaccharide from Burkholderia multivorans.Application of 707-07-3 And the article contains the following content:

The chem. synthesis of a tetrasaccharide repeating unit of the exopolysaccharide discovered from Burkholderia multivorans with a 3-aminopropyl group linked to the glycan downstream end, α-D-Manp-(1→2)-α-D-Manp-(1→2)-3-O-methyl-α-D-Rhap-(1→3)-α-D-Rhap-O(CH2)3NH2, was described. The target tetrasaccharide was achieved by both a convergent [2+2] and a linear glycosylation strategies. The latter synthesis was proved to be more efficient than the former due to the excellent stereocontrol of glycosylation. Furthermore, the 3-aminopropyl group in the target mol. would enable its conjugation with functional biomols. to explore its biol. applications. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Application of 707-07-3

The Article related to stereoselective glycosylation aminopropyl tetrasaccharide repeating unit exopolysaccharide burkholderia, burkholderia multivorans exopolysaccharide repeating unit oligosaccharide preparation and other aspects.Application of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 15, 2019, Hussein, Buthaina; Ikhmais, Balqis; Kadirvel, Manikandan; Magwaza, Rachael N.; Halbert, Gavin; Bryce, Richard A.; Stratford, Ian J.; Freeman, Sally published an article.SDS of cas: 707-07-3 The title of the article was Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinone oxidoreductase-2 (NQO2). And the article contained the following:

N1-ribosyl-, N1-methyl-, N1-benzyl-dihydronicotinamide:quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism Thus, there is a need to develop inhibitors of NQO2 that are active in vitro and in vivo. As part of a strategy to achieve this, 4-aminoquinoline backbone is used as a starting point and synthesized I [R = Me], II [R1 = Ph, 4-imidazoyl, 2-nitrofuranyl, etc.], III novel analogs. The syntheses utilized p-anisidine with Meldrum’s acid and tri-Me orthoacetate or tri-Me orthobenzoate to give the 4-hydrazin-quinoline scaffold I [R = Me, Ph], which was derivatized with aldehydes R1CHO or acid chlorides R1C(O)Cl to give hydrazone II or hydrazide analogs III, resp. The hydrazones II were the most potent inhibitors of NQO2 in cell free systems, some with low nano-molar IC50 values. Structure-activity anal. highlighted the importance of a small substituent at the 2-position of the 4-aminoquinoline ring, to reduce steric hindrance and improve engagement of the scaffold within the NQO2 active site. Cytotoxicity and NQO2-inhibitory activity in vitro was evaluated using ovarian cancer SKOV-3 and TOV-112 cells (expressing high and low levels of NQO2, resp.). Generally, the hydrazones were more toxic than hydrazide analogs and further, toxicity is unrelated to cellular NQO2 activity. Pharmacol. inhibition of NQO2 in cells was measured using the toxicity of CB1954 as a surrogate end-point. Both the hydrazone II and hydrazide derivs III. are functionally active as inhibitors of NQO2 in the cells, but at different inhibitory potency levels. In particular, 4-((2-(6-methoxy-2-methylquinolin-4-yl)hydrazono)methyl)phenol has the greatest potency of any compound yet evaluated (53 nM), which is 50-fold lower than its toxicity IC50. This compound and some of its analogs could serve as useful pharmacol. probes to determine the functional role of NQO2 in cancer development and response to therapy. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).SDS of cas: 707-07-3

The Article related to aminoquinoline hydrazone preparation antitumor docking quinone oxidoreductase inhibitor, 4-aminoquinoline, anticancer, cb1954, hydrazine, nqo2 inhibitors, ovarian cancer, skov-3 cells, tov-112d cells and other aspects.SDS of cas: 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 21, 2017, Taylor, Nicholas J.; Emer, Enrico; Preshlock, Sean; Schedler, Michael; Tredwell, Matthew; Verhoog, Stefan; Mercier, Joel; Genicot, Christophe; Gouverneur, Veronique published an article.Name: (Trimethoxymethyl)benzene The title of the article was Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands. And the article contained the following:

The compatibility of various heterocycles, particularly nitrogen heterocycles, towards the copper-mediated 18F-fluorination of aryl pinacolboronates with 18F-fluoride was determined using fluorination reactions of a model substrate in the presence of exogenous heterocycles and the fluorination reactions of substrates possessing heterocycles with fluorination on an attached aromatic ring or directly attached to the heterocycle of interest. Using this information, syntheses of seven 18F-labeled structurally complex pharmaceutically relevant heterocycle-containing mols. were designed and executed. The method may be useful in designing syntheses of other radiolabeled compounds and delineating the scope of utility of other radiolabeling methods. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Name: (Trimethoxymethyl)benzene

The Article related to robustness screen copper catalyzed radiofluorination, chemoselectivity copper catalyzed radiofluorination arylpinacolboronate attached unattached heterocycle, radiofluorinated pet mol synthetic design and other aspects.Name: (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 29, 2022, Loro, Camilla; Molteni, Letizia; Papis, Marta; Lo Presti, Leonardo; Foschi, Francesca; Beccalli, Egle M.; Broggini, Gianluigi published an article.Related Products of 707-07-3 The title of the article was Non-Decarboxylative Ruthenium-Catalyzed Rearrangement of 4-Alkylidene-isoxazol-5-ones to Pyrazole- and Isoxazole-4-carboxylic Acids. And the article contained the following:

Non-decarboxylative ruthenium-catalyzed rearrangement of 4-(2-hydroaminoalkylidenyl)- and 4-(2-hydroxyalkylidenyl)-substituted isoxazol-5(4H)-ones with catalytic amounts of [RuCl2(p-cymene)]2, without any additive, afforded pyrazole-4-carboxylic acids I [R1 = Me, Pr, Ph, etc.; R2 = H, Me, Et, etc.; R3 = Ph, CH2Bn, etc.] and isoxazole-4-carboxylic acids I [R1 = Me, Pr, Ph, etc.; R2 = H, Me, Ph, etc.] resp. The presence of an intramol. H-bond in these substrates was the key to divert the classical mechanism toward a ring-opening non-decarboxylative path that was expected to generate a vinyl Ru-nitrenoid intermediate, the cyclization of which afforded the rearranged products I and II. A gram scale protocol demonstrated the synthetic applicability of this transformation. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Related Products of 707-07-3

The Article related to pyrazole carboxylic acid preparation, hydroaminoalkylidenyl isoxazolone rearrangement ruthenium catalyst, isoxazole carboxylic acid preparation, hydroxyalkylidenyl isoxazolone rearrangement ruthenium catalyst and other aspects.Related Products of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2017, Abronina, Polina I.; Zinin, Alexander I.; Malysheva, Nelly N.; Stepanova, Elena V.; Chizhov, Alexander O.; Torgov, Vladimir I.; Kononov, Leonid O. published an article.SDS of cas: 707-07-3 The title of the article was A Novel Glycosyl Donor with a Triisopropylsilyl Nonparticipating Group in Benzyl-Free Stereoselective 1,2-cis-Galactosylation. And the article contained the following:

A novel glycosyl donor with a triisopropylsilyl (TIPS) nonparticipating group at O-2 is introduced for use in 1,2-cis-galactosylation. Coupling the 2-O-TIPS-substituted thiogalactoside donor with a series of mono- and disaccharide glycosyl acceptors was found to lead exclusively to α-linked oligosaccharides. The observed exceptionally high α-selectivity was interpreted in terms of conformational changes in the glycosyl cation induced by the bulky 2-O-TIPS group. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).SDS of cas: 707-07-3

The Article related to coupling disaccharide oligosaccharide protecting group preparation stereoselective glycosylation, stereoselective glycosylation galactosylation conformation glycoside preparation thioglycoside disaccharide trisaccharide and other aspects.SDS of cas: 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 1, 2017, Luo, Shipeng; Zhang, Xiao; Zheng, Yu; Harms, Klaus; Zhang, Lilu; Meggers, Eric published an article.Recommanded Product: (Trimethoxymethyl)benzene The title of the article was Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by a Sterically Highly Demanding Chiral-at-Rhodium Lewis Acid. And the article contained the following:

The enantioselective catalytic alkynylation of aromatic aldehydes is reported using a sterically highly hindered bis-cyclometalated rhodium-based Lewis acid catalyst featuring the octahedral metal as the only stereogenic center. Yields of 58-98% with 79-98% enantiomeric excess were achieved using 1-2 mol % of catalyst. This work complements previous work from the authors’ laboratory on the enantioselective alkynylation of 2-trifluoroacetyl imidazoles and trifluoromethyl ketones using catalysts with octahedral metal-centered chirality. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: (Trimethoxymethyl)benzene

The Article related to biscyclometalated rhodium lewis acid catalyst preparation mol crystal structure, arylaldehyde terminal alkyne enantioselective alkynylation biscyclometalated rhodium lewis acid, chiral diaryl propargylic alc preparation and other aspects.Recommanded Product: (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2020, Yakovenko, Georgiy G.; Lukianov, Oleh A.; Yagodkina-Yakovenko, Marta S.; Bol’but, Andriy V.; Vovk, Mikhailo V. published an article.Category: esters-buliding-blocks The title of the article was Synthesis of 5-amino-1H-pyrazolo[4,3-b]pyridine derivatives and annulation of imidazole and pyrimidine rings thereto. And the article contained the following:

A series of 5-amino-1H-pyrazolo[4,3-b]pyridine derivatives I [R1 = Me, Et, Ph, etc.; R2 = H, OMe; R3 = CN, C(O)NH2, CO2tBu] was synthesized via Friedlander reaction of N-Boc-protected 1-alkyl(aryl)-5-formyl-1Hpyrazol-4-amines with alkyl nitriles. Cyclocondensation of some of the compounds I with orthoesters, Et oxalyl chloride or carbonyldiimidazole to afford pyrazolo[3′,4′,5,6]pyrido[2,3-d]pyrimidine derivatives II [R4 = Me, tBu, Ph; R5 = H, iPr, Ph] and III [R1 = Me, Et, Ph, etc.] was reported. Cyclocondensation of some of the compounds I with chloroacetaldehyde, bromotrifluoroacetone or Et bromopyruvate to form imidazo[1,2-a]pyrazolo[3,4-e]pyridines IV [R6 = Me, Et, tBu, Ph; R2 = H, OMe; R7 = CN, C(O)NH2; R8 = H, CO2Et, CF3] was reported. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Category: esters-buliding-blocks

The Article related to amino pyrazolopyridine preparation, formyl pyrazole amine alkyl nitrile friedlander, imidazopyrazolopyridine preparation, carbonyl halide amino pyrazolopyridine cyclocondensation, pyrazolopyridopyrimidine preparation and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 17, 2014, Hodgson, David M.; Man, Stanislav; Powell, Kimberley J.; Perko, Ziga; Zeng, Minxiang; Moreno-Clavijo, Elena; Thompson, Amber L.; Moore, Michael D. published an article.Recommanded Product: (Trimethoxymethyl)benzene The title of the article was Intramolecular Oxonium Ylide Formation-[2,3] Sigmatropic Rearrangement of Diazocarbonyl-Substituted Cyclic Unsaturated Acetals: A Formal Synthesis of Hyperolactone C. And the article contained the following:

Rh(II)-catalyzed oxonium ylide formation-[2,3] sigmatropic rearrangement of α-diazo-β-ketoesters possessing γ-cyclic unsaturated acetal substitution, followed by acid-catalyzed elimination-lactonization, provides a concise approach to 1,7-dioxaspiro[4.4]non-2-ene-4,6-diones (e.g., I → II → III). The process creates adjacent quaternary stereocenters with full control of the relative stereochem. An unsym. monomethylated cyclic unsaturated acetal leads to hyperolactone C (IV), where ylide formation-rearrangement proceeds with high selectivity between subtly nonequivalent acetal oxygen atoms. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: (Trimethoxymethyl)benzene

The Article related to hyperolactone c formal synthesis, diazo carbonyl cyclic unsaturated acetal intramol oxonium ylide formation, sigmatropic rearrangement oxonium ylide formation diazocarbonyl cyclic unsaturated acetal, oxaspirononenedione preparation and other aspects.Recommanded Product: (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics