Category: 707-07-3

Liu, Yuxiao; Liu, Yu; Shanahan, Charles S.; Xu, Xichen; Doyle, Michael P. published an article in 2014, the title of the article was A survey of enol-diazo nucleophilicity in selective C-C bond forming reactions for the synthesis of natural product-like frameworks.Computed Properties of 707-07-3 And the article contains the following content:

A survey of in situ, catalytically generated carbocations for coupling with enol (diazo)acetate nucleophiles was performed. This coupling reaction facilitate a rapid assembly of complex organic diazo compounds that provide a template for the synthesis of a variety of carbocyclic and heterocyclic ring systems. Under optimized conditions the synthesis of the target compounds was achieved using scandium triflate (Lewis acid) as a catalyst for a reaction of 2-diazo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butenoic acid Me ester with α-(phenyl)benzenemethanol 1-acetate derivatives and orthoformate derivatives, such as 2,2′,2”-[methylidynetris(oxy)]tris[propane], tri-Me orthovalerate. The title compounds thus formed included α-(diazo)-β-(oxo)alkanoic acid esters, such as α-diazo-β-oxo-δ-(phenyl)benzenepentanoic acid Me ester. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Computed Properties of 707-07-3

The Article related to enol diazo nucleophile coupling reaction natural product like framework, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 707-07-3

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Bazhin, Denis N.; Kudyakova, Yulia S.; Roeschenthaler, Gerd-Volker; Burgart, Yanina V.; Slepukhin, Pavel A.; Isenov, Maksim L.; Saloutin, Victor I.; Charushin, Valery N. published an article in 2015, the title of the article was A Convenient Approach to CF3-Containing N-Heterocycles Based on 2-Methoxy-2-methyl-5-(trifluoromethyl)furan-3(2H)-one.Electric Literature of 707-07-3 And the article contains the following content:

New synthetic routes to trifluoromethylated N-heterocycles based on condensations of 2-methoxy-2-methyl-5-(trifluoromethyl)furan-3(2H)-one with bifunctional N-nucleophiles were described. For the first time, trifluoromethyl-containing pyrazoles, pyrazolines and isoxazolines bearing hydrazone or oxime groups could be obtained by a one-pot strategy based on reactions of 5-(trifluoromethyl)furan-3(2H)-one with two equivalent of the corresponding hydrazines or hydroxylamine in the presence of an acid. The interaction of furan-3(2H)-one with ureas proceeded under mild conditions to furnish 1H-furo[2,3-d]imidazol-2(3H)-one derivatives in good yield. Further, a trifluoromethyl-containing quinoxaline derivative was obtained by condensation of furan-3(2H)-one with ortho-phenylenediamine. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Electric Literature of 707-07-3

The Article related to methoxy methyltrifluoromethylfuranone nitrogen binucleophile, trifluoromethyl nitrogen heterocyclic preparation regioselective, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Electric Literature of 707-07-3

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Ester – Wikipedia,
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de La Torre, Aurelien; Lee, Yiu Yiu; Oger, Camille; Sangild, Per Torp; Durand, Thierry; Lee, Jetty Chung-Yung; Galano, Jean-Marie published an article in 2014, the title of the article was Synthesis, Discovery, and Quantitation of Dihomo-Isofurans: Biomarkers for In Vivo Adrenic Acid Peroxidation.Electric Literature of 707-07-3 And the article contains the following content:

The growing importance of lipidomics, and the interest of non-enzymic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Electric Literature of 707-07-3

The Article related to synthesis discovery quantitation dihomo isofuran biomarker adrenate peroxidation, biomarkers, lipids, mass spectrometry, oxidation, total synthesis, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Electric Literature of 707-07-3

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2018, Borys, Filip; Paprocki, Daniel; Koszelewski, Dominik; Ostaszewski, Ryszard published an article.COA of Formula: C10H14O3 The title of the article was The studies on the chemoenzymatic synthesis of 2-benzyl-3-butenoic acid. And the article contained the following:

The studies on the chemoenzymic synthesis of 2-benzyl-3-butenoic acid 3 were performed. The alkylation of dienolates derived from the crotonic and vinylacetic acids with different types of alkylating agents was examined In all cases the inseparable mixture of isomeric acids 3 and 4 were obtained. Chemoselective enzymic esterification of those mixtures provides ester 6 in 86% yield as a single product without double bond isomerization. None common method can be used for its hydrolysis since under basic conditions only isomeric acid 5 is formed. To overcome this limitation enzyme catalyzed hydrolysis process was design. This protocol afforded isomerically pure acid 3 in 98% yield. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).COA of Formula: C10H14O3

The Article related to chemoenzymic synthesis benzyl butenoic acid, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.COA of Formula: C10H14O3

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On March 4, 2013, Kaboudin, Babak; Khodamorady, Minoo; Abedi, Yaghoub published an article.Application of 707-07-3 The title of the article was A Practical and Convenient Method for the Synthesis of Some Benzimidazoles. And the article contained the following:

A new method for the synthesis of some benzimidazoles by the reaction of o-phenylenediamines with orthoesters under solvent-free conditions without any additives such as base, acid or catalyst is reported. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Application of 707-07-3

The Article related to phenylenediamine orthoester heterocyclization solventless, benzimidazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 707-07-3

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Masumoto, Eiichi; Nagabuchi, Hayate; Kashige, Nobuhiro; Okabe-Nakahara, Fumi; Miake, Fumio; Yamagata, Kenji; Maruoka, Hiroshi published an article in 2019, the title of the article was Synthesis and DNA cleavage activity of novel spiro-[cyclobutathiazole-4,4′-pyrazole] derivatives.Product Details of 707-07-3 And the article contains the following content:

A facile and efficient synthesis of novel spiro pyrazole derivatives containing cyclobutathiazole moiety was described. The key substrate pyrazole-thiazolidine derivative as the building block for bis-heterocycles was formed via a Knoevenagel-type condensation of thiazolidinedione with pyrazol-3-one. Thermal treatment of the pyrazole-thiazolidine derivative with orthoesters in refluxing toluene caused an C-attack nucleophilic substitution, followed by an intramol. cyclization/elimination sequence, giving the corresponding spiro[cyclobutathiazole-4,4′-pyrazole] derivatives All the synthesized compounds were characterized by spectroscopic anal. and were tested for their DNA cleavage activity in-vitro. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Product Details of 707-07-3

The Article related to pyrazolylidene thiazolidinone preparation dna cleavage activity, spiro cyclobutathiazole pyrazole preparation dna cleavage activity, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 707-07-3

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On June 3, 2020, Siddiqi, Zohaib; Wertjes, William C.; Sarlah, David published an article.Application of 707-07-3 The title of the article was Chemical Equivalent of Arene Monooxygenases: Dearomative Synthesis of Arene Oxides and Oxepines. And the article contained the following:

A general arenophile-based strategy for the dearomative synthesis of arene oxides. The mildness of this method permits access to sensitive monocyclic arene oxides without any noticeable decomposition to phenols. Moreover, this method enables direct conversion of polycyclic arenes and heteroarenes into the corresponding oxepines. Finally, these studies provided direct connection between simple aromatic precursors and complex small organic mols. via arene oxides and oxepines. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Application of 707-07-3

The Article related to arene cycloaddition dearomative epoxidation, epoxide preparation, oxepine preparation, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Application of 707-07-3

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2017, Park, Heemin; Kwon, Yongseok; Shin, Jae Eui; Kim, Woo-Jung; Hwang, Soonho; Lee, Seokwoo; Kim, Sanghee published an article.Quality Control of (Trimethoxymethyl)benzene The title of the article was Orthoester in Cyclodehydration of Carbamate-Protected Amino Alcohols under Acidic Conditions. And the article contained the following:

The first acid-promoted reaction system to form azaheterocycles from N-carbamate-protected amino alcs. is described. The reaction involves the activation of the hydroxyl group via the use of orthoesters. Despite the reduced nucleophilicity of carbamate nitrogen, this reaction system provides several types of pyrrolidines and piperidines in good to high yields. Using this protocol, prolinol derivatives can also be synthesized from carbamate-protected amino diols with regio- and stereoselectivity. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Quality Control of (Trimethoxymethyl)benzene

The Article related to carbamate protected amino alc orthoester cyclodehydration, pyrrolidine preparation, piperidine preparation, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Quality Control of (Trimethoxymethyl)benzene

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Ester – an overview | ScienceDirect Topics

On January 31, 2014, Majee, A.; Kundu, S. K.; Santra, S.; Hajra, A. published an article.Category: esters-buliding-blocks The title of the article was An improved procedure of Miyashita protocol for the preparation of ureidomethylene derivatives of 1,3-dicarbonyl compounds. And the article contained the following:

The synthesis of ureidomethylene derivatives I [R1 = CH3, OCH2CH3; R2 = CH3, OCH2CH3, OCH3, OC(CH3), etc.], through a three-component condensation of 1,3-dicarbonyl compounds, urea and trimethylorthoformate in presence of zinc triflate under solvent-free conditions, has been developed. Me substituted ureas also give the condensation product under similar reaction conditions. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Category: esters-buliding-blocks

The Article related to ureidomethylene preparation, urea trimethyl orthoformate dicarbonyl condensation, Aliphatic Compounds: Ketones and Derivatives, Including Sulfur Analogs and other aspects.Category: esters-buliding-blocks

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Ester – an overview | ScienceDirect Topics

On March 17, 2017, Gerasimaite, Ruta; Pavlovic, Igor; Capolicchio, Samanta; Hofer, Alexandre; Schmidt, Andrea; Jessen, Henning J.; Mayer, Andreas published an article.COA of Formula: C10H14O3 The title of the article was Inositol pyophosphate specificity of the SPX-dependent polyphosphate polymerase VTC. And the article contained the following:

The free energy of nucleotide hydrolysis depends on phosphate concentration Cells regulate cytosolic phosphate levels by orchestrating phosphate acquisition and storage through inositol pyrophosphates (PP-InsP) and SPX domains. Here, we report the synthesis of novel 5-PPP-InsP5 containing a triphosphate subunit. Using this and a series of synthetic PP-InsP, we examined the ligand specificity of the SPX domain in the PP-InsP-controlled yeast polyphosphate polymerase VTC. SPX decodes the relative positioning of the phosphoric anhydrides, their structure (diphosphate vs. triphosphate), and the presence of other phosphates on the inositol ring. Despite the higher potency of 1,5-(PP)2-InsP4, 5-PP-InsP5 was the primary activator of VTC in cells, indicating that its higher concentration compensated for its lower potency. 1,5-(PP)2-InsP4 levels rose and could become relevant under stress conditions. Thus, SPX domains may integrate PP-InsP-dependent signaling to adapt cytosolic phosphate concentrations to different metabolic situations. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).COA of Formula: C10H14O3

The Article related to spx domain dependent polyphosphate polymerase vtc inositol pyophosphate specificity, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.COA of Formula: C10H14O3

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics