Category: 707-07-3

On April 30, 2020, Sakai, Norio; Adachi, Shunpei; Ogawa, Sho; Takahashi, Kenshiro; Ogiwara, Yohei published an article.Safety of (Trimethoxymethyl)benzene The title of the article was One-Pot Synthesis of Dithioacetals and Diselenoacetals: An Indium-Catalyzed Reductive Insertion into Disulfides and Diselenides with Orthoesters as a Methylene Source. And the article contained the following:

A variety of dithioacetal derivatives were synthesized effectively via indium(III) catalyzed reductive insertion into either diaryl or dialkyl disulfides with orthoesters. This method was also adapted to the diselenoacetalization of diselenides. During a series of reductive insertions using this method, its noteworthy that an orthoester functions as a masked methylene moiety. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Safety of (Trimethoxymethyl)benzene

The Article related to disulfide orthoester indium catalyst insertion reaction, dithioacetal preparation, diselenide orthoester indium catalyst insertion reaction, diselenoacetal preparation, General Organic Chemistry: Synthetic Methods and other aspects.Safety of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Capolicchio, Samanta; Thakor, Divyeshsinh T.; Linden, Anthony; Jessen, Henning J. published an article in 2013, the title of the article was Synthesis of Unsymmetric Diphospho-Inositol Polyphosphates.Recommanded Product: (Trimethoxymethyl)benzene And the article contains the following content:

Synthesis of unsym. diphosphoinositol polyphosphates has been developed. The application of one single C2-Sym. phosphoramidite allows inositol to be de-symmetrized, accompanied by the direct introduction of an orthogonally protected phosphate triester, in all four relevant positions. It was shown that this approach is complementary to usually applied de-symmetrization with camphor acetals and is more efficient as a phosphate group is installed directly. Moreover, the auxiliary was cleanly removed upon treatment with base under very mild conditions, as expected from its kinship to the P-CE protecting group, allowing an efficient one-pot synthesis of the vital P-anhydride bond. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: (Trimethoxymethyl)benzene

The Article related to cyclitol inositol phosphoinositol phosphate synthesis protective group, Carbohydrates: Alditols, Cyclitols, Glycerides and other aspects.Recommanded Product: (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vibhute, Amol M.; Sureshan, Kana M. published an article in 2013, the title of the article was H2SO4-silica: an eco-friendly heterogeneous catalyst for the differential protection of myo-inositol hydroxyl groups.Computed Properties of 707-07-3 And the article contains the following content:

There is enormous interest in myo-inositol derivatives as they serve as precursors for the synthesis of several biol. important phosphoinositols, natural products, catalyst, supramol. architectures etc. However the presence of six secondary hydroxy groups of similar reactivity warrants protection of inositol hydroxyl groups for effective synthesis. Acid catalyzed protection of inositol hydroxyl groups as ortho esters or ketals are the most commonly used protecting strategy in inositol chem. Traditionally, homogeneous acid catalysts such as para-toluenesulfonic acid (p-TSA) or camphorsulfonic acid (CSA) are used for these transformations. While the reversible nature of these reactions necessitates the catalyst removal, aqueous work up cannot be employed for their removal as the products are water soluble The authors have circumvented this problem by using H2SO4-silica as the solid supported catalyst, which can be removed by filtration, for these transformations. Treatment of myoinositol with trialkyl ortho esters in presence of H2SO4-silica under normal conditions resulted in esterification at the least reactive hydroxyl group (C2-OH) giving exclusively the corresponding 2-O-acyl-myo-inositol. By doing the reaction in a rotary evaporator under reduced pressure resulted in the formation of the corresponding ortho esters, wherein three hydroxyl groups of inositol are protected simultaneously. The authors could synthesize different myo-inositol ortho esters 6-10 in excellent yields by this method. Ketalization of myo-inositol with one equivalent of 1,1-dimethoxycyclohexane or 2,2-dimethoxypropane in presence of H2SO4-silica under similar conditions resulted in the simultaneous protection of 1-OH and 2-OH giving the 1,2-O-cyclohexylidene-myo-inositol or 1,2-O-isopropylidene-myo-inositol in excellent yields. Also, diketalization of myo-inositol with 2,2-dimethoxypropane gave three diketals namely (±)-1,2:4,5-di-O-isopropylidene-myo-inositol (±)-1,2:5,6-di-O-isopropylidene-myo-inositol and (±)-1,2:3,4-di-O-isopropylidene-myoinositol in considerable yields. Similarly when dimethoxycyclohexane was used, the dicyclohexylidene derivatives (±)-1,2:4,5-di-O-cyclohexylidene-myo-inositol (±)-1,2:5,6-di-O-cyclohexylidene-myo-inositol and (±)-1,2:3,4-di-O-cyclohexylidene-myo-inositol were obtained in good yield. While the yields of 1,2:3,4-di-O-alkylidene-myo-inositols are negligibly small by other known methods, interestingly, our method give these diketals in good yields and hence can be exploited synthetically. Thus by using a cheap, eco-friendly, easy-to-make and easy-to-handle H2SO4-silica as the catalyst (green chem. method) the authors could tune the conditions to make mono-protected, di-protected, tri-protected or tetra-protected inositol derivatives This strategy can be applied for the economic synthesis of various key intermediates of inositol for various purposes. The title compounds thus formed included a myo-inositol ketal (I) and related substances. The synthesis of the target compounds was achieved using ortho esters, such as (trimethoxymethyl)benzene, 1,1,1-triethoxypentane, 1,1,1-triethoxybutane, 1,1-dimethoxycyclohexane, etc. as starting materials. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Computed Properties of 707-07-3

The Article related to inositol ortho ester preparation protective group, ketal inositol preparation protective group green chem solid acid, Carbohydrates: Alditols, Cyclitols, Glycerides and other aspects.Computed Properties of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 15, 2013, Godage, Himali Y.; Riley, Andrew M.; Woodman, Timothy J.; Thomas, Mark P.; Mahon, Mary F.; Potter, Barry V. L. published an article.COA of Formula: C10H14O3 The title of the article was Regioselective Opening of myo-Inositol Orthoesters: Mechanism and Synthetic Utility. And the article contained the following:

Acid hydrolysis of myo-inositol 1,3,5-ortho-esters, apart from ortho-formates, exclusively affords the corresponding 2-O-acyl myo-inositol products, e.g. I, via a 1,2-bridged five-membered ring dioxolanylium ion intermediate observed by NMR spectroscopy. These C-2-substituted inositol derivatives provide valuable precursors for rapid and highly efficient routes to 2-O-acyl inositol 1,3,4,5,6-pentakis-phosphates and myo-inositol 1,3,4,5,6-pentakis-phosphate with biol. interesting and anticancer properties. Deuterium incorporation into the α-methylene group of such alkyl ester products (2-O-C(O)CD2R), when the analogous alkyl ortho-ester is treated with deuterated acid, is established utilizing the novel orthoester myo-inositol 1,3,5-ortho-butyrate as an example. Such deuterated ester products provide intermediates for deuterium-labeled synthetic analogs. Investigation into this selective formation of 2-O-ester products and the deuterium incorporation is presented with proposed mechanisms from NMR experiments The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).COA of Formula: C10H14O3

The Article related to deuterium labeled inositol cyclitol preparation hydrolysis regioselective ring opening, inositol regioselective ring opening mechanism acid hydrolysis anticancer, Carbohydrates: Alditols, Cyclitols, Glycerides and other aspects.COA of Formula: C10H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 5, 2018, Brodzka, Anna; Koszelewski, Dominik; Zysk, Malgorzata; Ostaszewski, Ryszard published an article.Recommanded Product: 707-07-3 The title of the article was The mechanistic promiscuity of the enzymatic esterification of chiral carboxylic acids. And the article contained the following:

The studies on the enzymic kinetic resolution of 3-phenyl-4-pentenoic acid with various trialkyl orthoesters as alkoxy group donors are presented. The obtained results indicate that enantioselectivity of presented reaction is closely related to the alkoxy group donor structure. Based on critical anal. of the literature data and our own results we found that the previously recognized mechanism of such transformation is highly unlikely. In this paper we proposed a new revised mechanism explaining the role of alkoxy group donors. For trialkyl orthobenzoates excellent enzymic kinetic resolution of target substrate was achieved. The presented method is an unique example of an enzymic promiscuous activity toward esterification of carboxylic acids. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: 707-07-3

The Article related to lipase catalysis carboxylic acid esterification chiral ester kinetic resolution, Enzymes: Kinetics-Mechanism-Enzyme and Coenzyme Models and other aspects.Recommanded Product: 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Patel, Gautam; Roncal, Norma E.; Lee, Patricia J.; Leed, Susan E.; Erath, Jessey; Rodriguez, Ana; Sciotti, Richard J.; Pollastri, Michael P. published an article in 2014, the title of the article was Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.Quality Control of (Trimethoxymethyl)benzene And the article contains the following content:

Hesperadin, an established human Aurora B inhibitor, was tested against cultures of Trypanosoma brucei, Leishmania major, and Plasmodium falciparum, and was identified to be a potent proliferation inhibitor. A series of analogs was designed and tested to establish the initial structure-activity relationships for each parasite. In this study, we identified multiple non-toxic compounds with high potency against T. brucei and P. falciparum with good selectivity. These compounds may represent an opportunity for continued optimization. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Quality Control of (Trimethoxymethyl)benzene

The Article related to aurora kinase inhibitor hesperadin analog trypanosoma antiprotozoal drug discovery, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Quality Control of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 15, 2017, Zheng, Ruixiang Blake; Jegouzo, Sabine A. F.; Joe, Maju; Bai, Yu; Tran, Huu-Anh; Shen, Ke; Saupe, Jorn; Xia, Li; Ahmed, Faiaz Md.; Liu, Yu-Hsuan; Patil, Pratap Subhashrao; Tripathi, Ashish; Hung, Shang-Cheng; Taylor, Maureen E.; Lowary, Todd L.; Drickamer, Kurt published an article.Electric Literature of 707-07-3 The title of the article was Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans. And the article contained the following:

An array of homogeneous glycans representing all the major carbohydrate structures present in the cell wall of the human pathogen Mycobacterium tuberculosis and other mycobacteria has been probed with a panel of glycan-binding receptors expressed on cells of the mammalian innate immune system. The results provide an overview of interactions between mycobacterial glycans and receptors that mediate uptake and survival in macrophages, dendritic cells, and sinusoidal endothelial cells. A subset of the wide variety of glycan structures present on mycobacterial surfaces interact with cells of the innate immune system through the receptors tested. Endocytic receptors, including the mannose receptor, DC-SIGN, langerin, and DC-SIGNR (L-SIGN), interact predominantly with mannose-containing caps found on the mycobacterial polysaccharide lipoarabinomannan. Some of these receptors also interact with phosphatidyl-myo-inositol mannosides and mannose-containing phenolic glycolipids. Many glycans are ligands for overlapping sets of receptors, suggesting multiple, redundant routes by which mycobacteria can enter cells. Receptors with signaling capability interact with two distinct sets of mycobacterial glycans: targets for dectin-2 overlap with ligands for the mannose-binding endocytic receptors, while mincle binds exclusively to trehalose-containing structures such as trehalose dimycolate. None of the receptors surveyed bind furanose residues, which often form part of the epitopes recognized by antibodies to mycobacteria. Thus, the innate and adaptive immune systems can target different sets of mycobacterial glycans. This array, the first of its kind, represents an important new tool for probing, at a mol. level, biol. roles of a broad range of mycobacterial glycans, a task that has not previously been possible. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Electric Literature of 707-07-3

The Article related to mycobacterium surface glycan array host innate immuninty interaction, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.Electric Literature of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Yisheng; Wang, Subo; Wang, Guirong; Li, Hui; Guo, Zhongwu; Gu, Guofeng published an article in 2019, the title of the article was Synthesis and immunological studies of group A Streptococcus cell-wall oligosaccharide-streptococcal C5a peptidase conjugates as bivalent vaccines.Formula: C10H14O3 And the article contains the following content:

Group A Streptococcus (GAS) cell-wall polysaccharides and streptococcal C5a peptidase (ScpA) are identified as potential target antigens for the development of anti-GAS vaccines. Structurally well-defined mono-, di-, and trimers of the trisaccharide repeating unit of the major and conserved cell-wall polysaccharide of various GAS serotypes were synthesized by a convergent and efficient strategy. These synthetic oligosaccharides, which had a free amino group at the reducing end, were conjugated with a novel ScpA mutant ScpA193 protein through the bifunctional glutaryl linker. The resultant neoglycoproteins were evaluated as conjugate vaccines and compared with other glycoconjugates using the common carrier proteins diphtheria toxin mutant CRM197 and tetanus toxoid (TT). Immunol. studies using mice revealed that the ScpA193 conjugates could stimulate not only robust GAS oligosaccharide-specific antibody responses that were comparable to the immunol. activities of CRM197 and TT conjugates but also robust ScpA193-specific antibodies, making the ScpA193-oligosaccharide conjugates promising bivalent anti-GAS vaccine candidates. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Formula: C10H14O3

The Article related to tetanus crm197 scpa193 streptococcus polysaccharide conjugate vaccine, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.Formula: C10H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 15, 2016, Scott, Andrew E.; Christ, William J.; George, Alison J.; Stokes, Margaret G. M.; Lohman, Gregory J. S.; Guo, Yuhong; Jones, Matthew; Titball, Richard W.; Atkins, Timothy P.; Campbell, A. Stewart; Prior, Joann L. published an article.Safety of (Trimethoxymethyl)benzene The title of the article was Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate. And the article contained the following:

Melioidosis is an emerging infectious disease caused by Burkholderia pseudomallei and is associated with high morbidity and mortality rates in endemic areas. Antibiotic treatment is protracted and not always successful; even with appropriate therapy, up to 40% of individuals presenting with melioidosis in Thailand succumb to infection. In these circumstances, an effective vaccine has the potential to have a dramatic impact on both the scale and the severity of disease. Currently, no vaccines are licensed for human use. A leading vaccine candidate is the capsular polysaccharide consisting of a homopolymer of unbranched 1→3 linked 2-O-acetyl-6-deoxy-β-D-manno-heptopyranose. Here, we present the chem. synthesis of this challenging antigen using a novel modular disaccharide assembly approach. The resulting hexasaccharide was coupled to the nontoxic Hc domain of tetanus toxin as a carrier protein to promote recruitment of T-cell help and provide a scaffold for antigen display. Mice immunized with the glycoconjugate developed IgM and IgG responses capable of recognizing native capsule, and were protected against infection with over 120 × LD50 of B. pseudomallei strain K96243. This is the first report of the chem. synthesis of an immunol. relevant and protective hexasaccharide fragment of the capsular polysaccharide of B. pseudomallei and serves as the rational starting point for the development of an effective licensed vaccine for this emerging infectious disease. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Safety of (Trimethoxymethyl)benzene

The Article related to melioidosis vaccine synthetic burkholderia mannoheptopyranose hexasaccharide glycoconjugate, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.Safety of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2017, Furusho, Yoshio; Endo, Takeshi published an article.Name: (Trimethoxymethyl)benzene The title of the article was Reversible capture and release of carbon dioxide by binary system of polyamidine and polyethylene glycol. And the article contained the following:

CO2 absorbents were prepared from polyethylene glycol and polyamidines with N,N’-disubstituted amidine structure in the main chain synthesized by acid-catalyzed melt polycondensation of ortho-esters and α,ω-diamines. Homogeneous binary mixtures with polyamidines captured CO2 much more efficiently under CO2 flow than the one with polyethyleneimine. CO2 capture and release by the binary mixtures was assessed in terms of effect of volatility and polyamidine structure, temperature, and polyethylene glycol. Considering the obtained results, CO2 capture/release cycles with a CO2 capture step at 40° and a CO2 releasing step at 80° were conducted in an alternating manner, demonstrating the repeatability of CO2 capture/release by the polyamidine and polyethylene glycol binary system. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Name: (Trimethoxymethyl)benzene

The Article related to flue gas carbon dioxide absorption desorption system, preparation use polyamidine polyethylene glycol binary absorbent, Air Pollution and Industrial Hygiene: Industrial Waste Gases and other aspects.Name: (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics