Category: 707-07-3

On March 1, 2021, Cerciello, F.; Apicella, B.; Russo, C.; Cortese, L.; Senneca, O. published an article.Application of 707-07-3 The title of the article was Effects of pressure on lignocellulosic biomass fast pyrolysis in nitrogen and carbon dioxide. And the article contained the following:

The present study investigates the influence of pressure on the products of fast pyrolysis of a lignocellulosic biomass (Walnut Shells). Experiments were carried out using a special heated strip reactor (HSR) at temperature of 1573 and 2073 K, pressure up to 8 bar and heating rate of 104 K/s. Two atmospheres have been investigated: N2 and CO2. Increasing the pressure of heat treatment, the combustion pattern and the average combustion reactivity of the chars change remarkably. Multiple components with different combustion reactivity have been found in the char samples. Upon heat treatment in N2 the most reactive components are depleted more easily than upon heat treatment in CO2. Consequently, thermodeactivation is more severe in N2 than in CO2. Raman anal. of the chars shows that graphitic order develops only upon heat treatment at 2073 K at the pressure of 2 bar, but not upon heat treatment at 1573 K, not even at the higher pressure investigated (4 and 8 bar). The loss of reactivity induced by pressure is therefore ascribed to changes in the internal distribution of char components. The evolution of the solid components is accompanied by changes in the distribution of aliphatics/methoxy aromatic compounds in the produced tar. The interplay of temperature, pressure, and CO2 affects both mineral matter and the carbon matrix resulting into a rather complex behavior. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Application of 707-07-3

The Article related to nitrogen carbon dioxide pressure lignocellulosic biomass pyrolysis, Placeholder for records without volume info and other aspects.Application of 707-07-3

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Zdun, Beata; Ciesla, Piotr; Kutner, Jan; Borowiecki, Pawel published an article in 2022, the title of the article was Expanding Access to Optically Active Non-Steroidal Anti-Inflammatory Drugs via Lipase-Catalyzed KR of Racemic Acids Using Trialkyl Orthoesters as Irreversible Alkoxy Group Donors.HPLC of Formula: 707-07-3 And the article contains the following content:

Studies into the enzymic kinetic resolution (EKR) of 2-arylpropanoic acids (′profens′), as the active pharmaceutical ingredients (APIs) of blockbuster non-steroidal anti-inflammatory drugs (NSAIDs), by using various trialkyl orthoesters as irreversible alkoxy group donors in organic media, were performed. The enzymic reactions of target substrates were optimized using several different immobilized preparations of lipase type B from the yeast Candida antarctica (CAL-B). The influence of crucial parameters, including the type of enzyme and alkoxy agent, as well as the nature of the organic co-solvent and time of the process on the conversion and enantioselectivity of the enzymic kinetic resolution, is described. The optimal EKR procedure for the racemic profens consisted of a Novozym 435-STREM lipase preparation suspended in a mixture of 3 equiv of tri-Me or tri-Et orthoacetate as alkoxy donor and toluene or n-hexane as co-solvent, depending on the employed racemic NSAIDs. The reported biocatalytic system provided optically active products with moderate-to-good enantioselectivity upon esterification lasting for 7-48 h, with most promising results in terms of enantiomeric purity of the pharmacol. active enantiomers of title APIs obtained on the anal. scale for: (S)-flurbiprofen (97% ee), (S)-ibuprofen (91% ee), (S)-ketoprofen (69% ee), and (S)-naproxen (63% ee), resp. In turn, the employment of optimal conditions on a preparative-scale enabled us to obtain the (S)-enantiomers of: flurbiprofen in 28% yield and 97% ee, ibuprofen in 45% yield and 56% ee, (S)-ketoprofen in 23% yield and 69% ee, and naproxen in 42% yield and 57% ee, resp. The devised method turned out to be inefficient toward racemic etodolac regardless of the lipase and alkoxy group donor used, proving that it is unsuitable for carboxylic acids possessing tertiary chiral centers. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).HPLC of Formula: 707-07-3

The Article related to arylpropanoic acid enzymic kinetic resolution lipase catalyzed nsaid, Placeholder for records without volume info and other aspects.HPLC of Formula: 707-07-3

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Hellmuth, Isabell; Freund, Isabel; Schloeder, Janine; Seidu-Larry, Salifu; Thuering, Kathrin; Slama, Kaouthar; Langhanki, Jens; Kaloyanova, Stefka; Eigenbrod, Tatjana; Krumb, Matthias; Roehm, Sandra; Peneva, Kalina; Opatz, Till; Jonuleit, Helmut; Dalpke, Alexander H.; Helm, Mark published an article in 2017, the title of the article was Bioconjugation of small molecules to RNA impedes its recognition by toll-like receptor 7.Product Details of 707-07-3 And the article contains the following content:

A fundamental mechanism of the innate immune system is the recognition, via extra- and intracellular pattern-recognition receptors, of pathogen-associated mol. patterns. A prominent example is represented by foreign nucleic acids, triggering the activation of several signaling pathways. Among these, the endosomal toll-like receptor 7 (TLR7) is known to be activated by single-stranded RNA (ssRNA), which can be specifically influenced through elements of sequence structure and posttranscriptional modifications. Furthermore, small mols. TLR7 agonists (smTLRa) are applied as boosting adjuvants in vaccination processes. In this context, covalent conjugations between adjuvant and vaccines have been reported to exhibit synergistic effects. Here, we describe a concept to chem. combine three therapeutic functions in one RNA bioconjugate. This consists in the simultaneous TLR7 stimulation by ssRNA and smTLRa as well as the therapeutic function of the RNA itself, e.g., as a vaccinating or knockdown agent. We have hence synthesized bioconjugates of mRNA and siRNA containing covalently attached smTLRa and tested their function in TLR7 stimulation. Strikingly, the bioconjugates displayed decreased rather than synergistically increased stimulation. The decrease was distinct from the antagonistic action of an siRNA bearing a Gm motive, as observed by direct comparison of the effects in the presence of otherwise stimulatory RNA. In summary, these investigations showed that TRL7 activation can be impeded by bioconjugation of small mols. to RNA. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Product Details of 707-07-3

The Article related to tlr7 rna bioconjugate immunostimulation, bioconjugate, click chemistry, immunostimulation, mrna, sirna, small molecules, toll-like receptor, Placeholder for records without volume info and other aspects.Product Details of 707-07-3

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On June 1, 2021, Czescik, Joanna; Mancin, Fabrizio; Stroemberg, Roger; Scrimin, Paolo published an article.SDS of cas: 707-07-3 The title of the article was The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme. And the article contained the following:

The cleavage of uridine 3′-phosphodiesters bearing alcs. with pKa ranging from 7.14 to 14.5 catalyzed by AuNPs functionalized with 1,4,7-triazacyclononane-Zn(II) complexes has been studied to unravel the source of catalysis by these nanosystems (nanozymes). The results have been compared with those obtained with two Zn(II) dinuclear catalysts for which the mechanism is fairly understood. Binding to the Zn(II) ions by the substrate and the uracil of uridine was observed The latter leads to inhibition of the process and formation of less productive binding complexes than in the absence of the nucleobase. The nanozyme operates with these substrates mostly via a nucleophilic mechanism with little stabilization of the pentacoordinated phosphorane and moderate assistance in leaving group departure. This is attributed to a decrease of binding strength of the substrate to the catalytic site in reaching the transition state due to an unfavorable binding mode with the uracil. The nanozyme favors substrates with better leaving groups than the less acidic ones. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).SDS of cas: 707-07-3

The Article related to rna phosphodiester cleavage gold nanoparticle nanozyme, brønsted plot, rna cleavage, gold nanoparticles, metal ion catalysis, phosphate cleavage, Placeholder for records without volume info and other aspects.SDS of cas: 707-07-3

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On November 30, 2017, Sanches Filho, Pedro Jose; Silveira, Lucas Aldrigui; Betemps, Glauco Rasmussen; Montenegro, Gissele Oliveira; Sampaio, Daniele Martin; Caramao, Elina Bastos published an article.Name: (Trimethoxymethyl)benzene The title of the article was Application of the SARA method for determination of hydrocarbons by GC/qMS in bio-oil obtained by fast pyrolysis of rice husk. And the article contained the following:

This study presents the results of the use of fractionation preparative liquid chromatog. (PLC) on columns of silica (based on the SARA method, traditionally used for oil samples). For characterization of bio-oils obtained by fast pyrolysis of rice husk. The method distributes compounds separating into four fractions, the majority polar compounds (F3 and F4) and hydrocarbons (F1 and F2). The fractions were analyzed by GC/MS allowing the identification and semi-quant. determination of aliphatic hydrocarbons and HPAS. After the fractionation by PLC, only F1, F2 and F3 were possible to identify, a total of 180 compounds The fractionation based on the SARA method, with modification, produced fractions (F1 and F2) free of polar compounds permitting the identification of aliphatic hydrocarbons and PAHs. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Name: (Trimethoxymethyl)benzene

The Article related to hydrocarbon biooil fast pyrolysis rice husk sara method, Organic Analytical Chemistry: Determinations and other aspects.Name: (Trimethoxymethyl)benzene

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Brachvogel, Rene-Chris; von Delius, Max published an article in 2015, the title of the article was Orthoester exchange: a tripodal tool for dynamic covalent and systems chemistry.Safety of (Trimethoxymethyl)benzene And the article contains the following content:

The acid-catalyzed exchange of O,O,O-orthoesters to the toolbox of dynamic covalent chem. was investigated. The orthoesters readily exchanged with a wide range of alcs. under mild conditions. The dynamic orthoester systems gave rise to pronounced metal template effects, which could best be understood by agonistic relationships in a three-dimensional network anal. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Safety of (Trimethoxymethyl)benzene

The Article related to ester preparation, alc ester exchange reaction acid catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of (Trimethoxymethyl)benzene

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On July 2, 2018, Verrier, Charlie; Carret, Sebastien; Poisson, Jean-Francois published an article.Formula: C10H14O3 The title of the article was Metal Free, Microwave Assisted Preparation of N-Sulfonyl and N-Sulfinyl Imines and Imidates. And the article contained the following:

A general method for the preparation of N-sulfonyl and N-sulfinyl imines and imidates under microwave irradiation is described. The conditions developed avoid the use of strong Lewis or Bronsted acids, limit the use of polluting solvents and of an excess of a dehydrating agent, affording the imines and imidates in high yields within short reaction time. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Formula: C10H14O3

The Article related to microwave assisted sulfonyl sulfinyl imine imidate preparation, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C10H14O3

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On April 5, 2019, Cortigiani, Mauro; Mereu, Andrea; Gillick Healy, Malachi; Adamo, Mauro F. A. published an article.Name: (Trimethoxymethyl)benzene The title of the article was Enantioselective Desymmetrization of cis-3,5-O-Arylidenecyclohexanones Catalyzed by Cinchona-Derived Quaternary Ammonium Salts. And the article contained the following:

An enantioselective protocol for the desymmetrization of cis-3,5-O-arylidenecyclohexanones was developed that proceeded under the catalysis of readily available and inexpensive Cinchona-derived quaternary ammonium salts. The synthetic relevance of the methodol. was exemplified by the synthesis of a key intermediate that could be used in the preparation of the active pharmaceutical ingredient, paricalcitol (Zemplar). The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Name: (Trimethoxymethyl)benzene

The Article related to enantioselective desymmetrization arylidenecyclohexanone catalyst cinchona quaternary ammonium salt, General Organic Chemistry: Synthetic Methods and other aspects.Name: (Trimethoxymethyl)benzene

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Ester – an overview | ScienceDirect Topics

Kramer, Stefan; Langhanki, Jens; Krumb, Matthias; Opatz, Till; Bros, Matthias; Zentel, Rudolf published an article in 2019, the title of the article was HPMA-Based Nanocarriers for Effective Immune System Stimulation.Synthetic Route of 707-07-3 And the article contains the following content:

The selective activation of the immune system using nanoparticles as a drug delivery system is a promising field in cancer therapy. Block copolymers from HPMA and laurylmethacrylate-co-hymecromone-methacrylate allow the preparation of multifunctionalized core-crosslinked micelles of variable size. To activate dendritic cells (DCs) as antigen presenting cells, the carbohydrates mannose and trimannose are introduced into the hydrophilic corona as DC targeting units. To activate DCs, a lipophilic adjuvant (L18-MDP) is incorporated into the core of the micelles. To elicit an immune response, a model antigen peptide (SIINFEKL) is attached to the polymeric nanoparticle-in addition-via a click reaction with the terminal azide. Thereafter, the differently functionalized micelles are chem. and biol. characterized. While the core-crosslinked micelles without carbohydrate units are hardly bound by DCs, mannose and trimannose functionalization lead to a strong binding. Flow cytometric anal. and blocking studies employing mannan suggest the requirement of the mannose receptor and DC-SIGN for effective micelle binding. It could be suppressed by blocking with mannan. Adjuvant-loaded micelles functionalized with mannose and trimannose activate DCs, and DCs preincubated with antigen-conjugated micelles induce proliferation of antigen-specific CD8+ T cells. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Synthetic Route of 707-07-3

The Article related to immune system stimulation micelle nanocarrier mannose trimannose, hpma block copolymers, micelles, targeting, trimannose, vaccines, Pharmaceuticals: Formulation and Compounding and other aspects.Synthetic Route of 707-07-3

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Ester – an overview | ScienceDirect Topics

Elsaidi, Hassan R. H.; Lowary, Todd L. published an article in 2014, the title of the article was Inhibition of Cytokine Release by Mycobacterium tuberculosis Phenolic Glycolipid Analogues.Recommanded Product: 707-07-3 And the article contains the following content:

Infection by Mycobacterium tuberculosis causes tuberculosis, a disease characterized by alteration of host innate and adaptive immunity. These processes are mediated by a series of bacterial biomols., among which phenolic glycolipids (PGLs) and the related p-hydroxybenzoic acid derivatives have been suggested to play important roles. To probe the importance of structural features of these glycans on cytokine modulation, we synthesized three M. tuberculosis PGL analogs (1-3), which differ from the native glycoconjugates by possessing a simplified lipid aglycon. The ability of 1-3 to modulate the release of proinflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1) and nitric oxide (NO) was evaluated. None of the compounds stimulated the secretion of these signalling mols. However, all showed a Toll-like Receptor 2-mediated, concentration-dependent inhibition profile that was related to the methylation pattern on the glycan. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: 707-07-3

The Article related to mycobacterium phenolic glycolipid cytokine, toll-like receptors, cytokines, glycolipids, immunomodulators, mycobacteria, tuberculosis, Immunochemistry: Interferons and Lymphokines and other aspects.Recommanded Product: 707-07-3

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Ester – an overview | ScienceDirect Topics