Category: 707-07-3

Vinnitskiy, Dmitry Z.; Krylov, Vadim B.; Ustyuzhanina, Nadezhda E.; Dmitrenok, Andrey S.; Nifantiev, Nikolay E. published an article in 2016, the title of the article was The synthesis of heterosaccharides related to the fucoidan from Chordaria flagelliformis bearing an α-L-fucofuranosyl unit.Category: esters-buliding-blocks And the article contains the following content:

Sulfated polysaccharides, fucoidans, from brown algae are built up mainly of α-L-fucopyranosyl units and form a group of natural biopolymers with a wide spectrum of biol. activities. Systematic synthesis of oligosaccharides representing fucoidans’ fragments gives mol. probes for detecting pharmacophores within fucoidan polysaccharide chains. Recently, it was discovered that the fucoidan from brown seaweed Chordaria flagelliformis contains not only α-L-fucopyranosyl units but also α-L-fucofuranosyl ones. To establish the influence of the unusual α-L-fucofuranose residue on the biol. activity and conformational properties of fucoidans, the synthesis of selectively O-sulfated pentasaccharides, which represent the main repeating unit of the fucoidan from C. flagelliformis, was performed. The features of the synthesis were the use of the pyranoside-into-furanoside rearrangement to prepare the fucofuranoside precursor and remote stereocontrolling participation of O-acyl groups to manage stereoselective α-bond formation in glycosylation reactions. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Category: esters-buliding-blocks

The Article related to fucose oligosaccharide preparation fucoidan chordaria flagelliformis, Carbohydrates: Acids and other aspects.Category: esters-buliding-blocks

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 16, 2014, Zhou, Jun; Yang, Liping; Hu, Wenhao published an article.Electric Literature of 707-07-3 The title of the article was Stereoselective Synthesis of a Sulfated Tetrasaccharide Corresponding to a Rare Sequence in the Galactofucan Isolated from Sargassum polycystum. And the article contained the following:

The first chem. synthesis of a highly sulfated tetrasaccharide 1, as the rare sequence in the galactofucan isolated from the brown alga Sargassum polycystum, was achieved in a convergent and stereoselective manner. The key features of the synthetic strategy include construction of multiple contiguous 1,2-cis glycosidic bonds and [2+2] assembly based on the rationally developed D-galactose building block 6. The synthesized oligosaccharides were fully characterized using a combination of coupled-HSQC and other 2D NMR techniques. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Electric Literature of 707-07-3

The Article related to sulfated oligosaccharide stereoselective synthesis galactofucan sargassum polycystum, Carbohydrates: Acids and other aspects.Electric Literature of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pavlovic, I.; Thakor, D. T.; Jessen, H. J. published an article in 2016, the title of the article was Synthesis of 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate and a photocaged analogue.Recommanded Product: 707-07-3 And the article contains the following content:

Diphosphoinositol polyphosphates (inositol pyrophosphates, X-InsP7) are a family of second messengers with important roles in eukaryotic biol. Their chem. synthesis and modification remains a challenging task due to the high d. of phosphate groups arranged around the myo-inositol core. Here, a novel approach is presented that facilitates the incorporation of the diphosphate in the 2-position (2-InsP7) and that enables the introduction of a photocage subunit. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: 707-07-3

The Article related to diphosphoinositol polyphosphate photocaged analog preparation enzyme inositol pyrophosphate turnover, Carbohydrates: Acids and other aspects.Recommanded Product: 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chang, Sue-Ming; Tu, Zhijay; Jan, Hau-Ming; Pan, Jia-Fu; Lin, Chun-Hung published an article in 2013, the title of the article was Rapid synthesis of oligomannosides with orthogonally protected monosaccharides.Product Details of 707-07-3 And the article contains the following content:

We developed a facile synthesis to yield orthogonally protected mannose building blocks with high overall yields. The protection/glycosylation steps can be carried out in a successive manner without purification of intermediate products. This developed synthesis led to formation of linear/branched tri-, penta- and heptasaccharides. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Product Details of 707-07-3

The Article related to linear oligomannoside preparation orthogonally protected monosaccharide, branched oligomannoside preparation orthogonally protected monosaccharide, Carbohydrates: Acids and other aspects.Product Details of 707-07-3

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On October 2, 2020, Lin, Sicheng; Lowary, Todd L. published an article.Quality Control of (Trimethoxymethyl)benzene The title of the article was Synthesis of a Highly Branched Nona-saccharide Chlorella Virus N-Glycan Using a “Counter-clockwise” Assembly Approach. And the article contained the following:

Chlorovirus produce a capsid protein containing N-linked glycans differing in structure from those found in all other organisms. These species feature a core “hyper-branched” fucose residue in which every hydroxyl group is glycosylated. We describe the synthesis of a nonasaccharide from Paramecium bursaria chlorella virus 1, one of most complex chlorovirus N-glycans reported, using a “counter-clockwise” strategy involving the sequential addition of trisaccharide, disaccharide, and monosaccharide motifs to a trisaccharide containing the core fucose residue. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Quality Control of (Trimethoxymethyl)benzene

The Article related to amino acid oligosaccharide preparation, oligosaccharide nonasaccharide chlorella virus glycan synthesis trisaccharide disaccharide, Carbohydrates: Amines and other aspects.Quality Control of (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 18, 2014, Das, Rituparna; Mahanti, Mukul; Mukhopadhyay, Balaram published an article.Electric Literature of 707-07-3 The title of the article was Concise synthesis of the tetrasaccharide repeating unit of the O-polysaccharide isolated from Edwardsiella tarda PCM 1156 strain. And the article contained the following:

A convergent strategy has been developed for the synthesis of the tetrasaccharide repeating unit of the O-antigen from Edwardsiella tarda PCM 1156. Sequential glycosylations of a series of rationally protected monosaccharide intermediates were achieved either by the activation of thioglycosides using N-iodosuccinimide (NIS) in conjunction with H2SO4-silica or by activation of trichloroacetimidate by H2SO4-silica only. All glycosylation reactions resulted in the formation of the desired linkage with absolute stereoselectivity and yielded the required derivatives in good to excellent yields. Both azido and phthalimido groups have been used as the precursor of the desired acetamido group depending on the requirement of 1,2-cis- or 1,2-trans-glycosidic linkage. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Electric Literature of 707-07-3

The Article related to edwardsiella tarda tetrasaccharide repeating unit preparation sequential glycosylation, acetamido sugars, bacterial o-antigen, h(2)so(4)–silica, Carbohydrates: Amines and other aspects.Electric Literature of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thota, V. Narasimharao; Ferguson, Michael J.; Sweeney, Ryan P.; Lowary, Todd L. published an article in 2018, the title of the article was Synthesis of the Campylobacter jejuni 81-176 Strain Capsular Polysaccharide Repeating Unit Reveals the Absolute Configuration of its O-Methyl Phosphoramidate Motif.COA of Formula: C10H14O3 And the article contains the following content:

The O-Me phosphoramidate (MeOPN) motif is a non-stoichiometric modification of capsular polysaccharides (CPS) in �0 % of all Campylobacter jejuni strains. Infections by C. jejuni lead to food-borne illnesses and the CPS they produce are key virulence factors. The MeOPN phosphorus atom in these CPS is stereogenic and is found as a single stereoisomer. However, to date, the absolute stereochem. at this atom has been undefined. We report the synthesis of the three repeating units found in C. jejuni 81-176 CPS; one of these possesses a MeOPN group. In the course of these studies we established that the stereochem. of the phosphorus atom in this MeOPN group is R. These studies represent the first unequivocal proof of stereochem. of this group in any C. jejuni CPS. The compounds produced are anticipated to be useful tools in investigations targeting the function and biosynthesis of this structurally-interesting modification, which so far has only been identified in campylobacter. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).COA of Formula: C10H14O3

The Article related to amino trisaccharide synthon capsular polysaccharide campylobacter jejuni, 6-deoxyheptose, nmr spectroscopy, capsular polysaccharide, glycosylation, phosphoramidate, Carbohydrates: Amines and other aspects.COA of Formula: C10H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 1, 2022, Kim, Taeok; Bell, Michael R.; Thota, V. Narasimharao; Lowary, Todd L. published an article.SDS of cas: 707-07-3 The title of the article was One-Pot Regioselective Diacylation of Pyranoside 1,2-cis Diols. And the article contained the following:

A one-pot strategy for functionalizing pyranoside 1,2-cis-diols with two different ester protecting groups is reported. The approach employs regioselective acylation via orthoester hydrolysis promoted by a carboxylic acid, e.g., levulinic acid, acetic acid, benzoic acid, or chloroacetic acid. Upon removal of water and introduction of a coupling agent, the carboxylic acid is esterified to the hydroxyl group liberated during hydrolysis. Although applied to 1,2-cis-diols on pyranoside scaffolds, the method should be applicable to such motifs on any six-membered ring. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).SDS of cas: 707-07-3

The Article related to carboxylic acid catalyst regioselective acylation hydrolysis protecting group coupling, hydrolysis regioselective diacylation pyranoside diol ester protecting group, Carbohydrates: Glycosides and other aspects.SDS of cas: 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 18, 2020, Zheng, Xiaoli; Li, Zhuoru; Gao, Wei; Meng, Xiaoting; Li, Xuefei; Luk, Louis Y. P.; Zhao, Yibing; Tsai, Yu-Hsuan; Wu, Chuanliu published an article.COA of Formula: C10H14O3 The title of the article was Condensation of 2-((Alkylthio)(aryl)methylene)malononitrile with 1,2-Aminothiol as a Novel Bioorthogonal Reaction for Site-Specific Protein Modification and Peptide Cyclization. And the article contained the following:

Site-specific modification of peptides and proteins has wide applications in probing and perturbing biol. systems. Herein we report that 1,2-aminothiol can react rapidly, specifically and efficiently with 2-((alkylthio)(aryl)methylene)malononitrile (TAMM) under biocompatible conditions. This reaction undergoes a unique mechanism involving thiol-vinyl sulfide exchange, cyclization, and elimination of dicyanomethanide to form 2-aryl-4,5-dihydrothiazole (ADT) as a stable product. An 1,2-aminothiol functionality can be introduced into a peptide or a protein as an N-terminal cysteine or an unnatural amino acid. The bioorthogonality of this reaction was demonstrated by site-specific labeling of not only synthetic peptides and a purified recombinant protein but also proteins on mammalian cells and phages. Unlike other reagents in bioorthogonal reactions, the chem. and phys. properties of TAMM can be easily tuned. TAMM can also be applied to generate phage-based ADT-cyclic peptide libraries without reducing phage infectivity. Using this approach, we identified ADT-cyclic peptides with high affinity to different protein targets, providing valuable tools for biol. studies and potential therapeutics. Furthermore, the mild reaction conditions of TAMM condensation warrant its use with other bioorthogonal reactions to simultaneously achieve multiple site-specific modifications. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).COA of Formula: C10H14O3

The Article related to sequence alkylthio aryl methylene malononitrile aminothiol bioorthogonal reaction, bioorthogonal reaction protein modification peptide cyclization, Biochemical Methods: Reagents and other aspects.COA of Formula: C10H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 20, 2015, Salamone, Stephane; Guerreiro, Catherine; Cambon, Emmanuelle; Hargreaves, Jason M.; Tarrat, Nathalie; Remaud-Simeon, Magali; Andre, Isabelle; Mulard, Laurence A. published an article.Synthetic Route of 707-07-3 The title of the article was Investigation on the Synthesis of Shigella flexneri Specific Oligosaccharides Using Disaccharides as Potential Transglucosylase Acceptor Substrates. And the article contained the following:

Chemo-enzymic strategies hold great potential for the development of stereo- and regioselective syntheses of structurally defined bioactive oligosaccharides. Herein, we illustrate the potential of the appropriate combination of a planned chemo-enzymic pathway and an engineered biocatalyst for the multistep synthesis of an important decasaccharide for vaccine development. We report the stepwise investigation, which led to an efficient chem. conversion of allyl α-D-glucopyranosyl-(1â†?)-α-L-rhamnopyranosyl-(1â†?)-2-deoxy-2-trichloroacetamido-β-D-glucopyranoside, the product of site-specific enzymic α-D-glucosylation of a lightly protected non-natural disaccharide acceptor, into a pentasaccharide building block suitable for chain elongation at both ends. Successful differentiation between hydroxyl groups features the selective acylation of primary alcs. and acetalation of a cis-vicinal diol, followed by a controlled per-O-benzylation step. Moreover, we describe the successful use of the pentasaccharide intermediate in the [5 + 5] synthesis of an aminoethyl aglycon-equipped decasaccharide, corresponding to a dimer of the basic repeating unit from the O-specific polysaccharide of Shigella flexneri 2a, a major cause of bacillary dysentery. Four analogs of the disaccharide acceptor were synthesized and evaluated to reach a larger repertoire of O-glucosylation patterns encountered among S. flexneri type-specific polysaccharides. New insights on the potential and limitations of planned chemo-enzymic pathways in oligosaccharide synthesis are provided. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Synthetic Route of 707-07-3

The Article related to oligosaccharide pp polysaccharide shigella flexneri bacillary dysentery glucosylation transglucosylase, Carbohydrates: Oligosaccharides and other aspects.Synthetic Route of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics