Category: 70347-04-5

Reference of 70347-04-5, The chemical industry reduces the impact on the environment during synthesis 70347-04-5, name is Methyl 4-methoxy-3-methylbenzoate, I believe this compound will play a more active role in future production and life.

To a mixture of methyl 4-methoxy-3-methylbenzoate (1.0 eq) in CCl4 (0.37M), NBS (1.1 eq) and AIBN (0.2 eq) was stirred overnight at 95 C. under nitrogen atmosphere. The resulting mixture was concentrated and partitioned between DCM and water, the organic layer was dried over Na2SO4, concentrated and purified by flash chromatography on silica (eluent PE/EA=100:1 to 20:1) to give the title compound as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-methoxy-3-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Apros Therapeutics, Inc.; WU, Tom Yao-Hsiang; (209 pag.)US2018/155298; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 70347-04-5, name is Methyl 4-methoxy-3-methylbenzoate, A new synthetic method of this compound is introduced below., Product Details of 70347-04-5

Reference example 57 Methyl 3-bromomethyl-4-methoxybenzoate To a solution of methyl 3-methyl-4-methoxybenzoate (3.0g, 16.5mmol) which was prepared in Reference example 56 in carbon tertachloride (100ml) were added N-bromosuccinimide (2.9g, 16.5mmol) and benzoyl peroxide (0.10g), and the mixture was refluxed for 6 hours. After being cooled to 0C, the precipitate was filtered, and to the filtrate was added a saturated aqueous sodium thiosulfate solution (1ml). The solution was stirred for 15 minutes and concentrated in vacuo. To the residue was added water and the solution was extracted with chloroform 50 ml*3). The organic layer was concentrated and the precipitated solid was filtered to give the titled compound as a white solid (3.0 g, 11.7 mmol). Yield: 70%. 1H NMR(CDCl3)delta 8.04-7.99(2H, m), 6.91(1H, d, J = 8.6 Hz), 4.55(2H, s), 3.97(3H, s), 3.89(3H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; AstraZeneca AB; EP1728792; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 70347-04-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 70347-04-5, name is Methyl 4-methoxy-3-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Methyl 4-methoxy-3-methylbenzoate (16 g) was dissolved in EtOAc (100 mL) and then N- bromosuccinimide (18.96 g) and 2,2′-azobisisobutyronitrile (1 g) were added. The mixture was then heated to 800C for 4 h. After cooling to r.t. sat. sodium thiosulfate solution was added, the organic phase was separated, washed with brine, dried and the solvents removed by evaporation. The crude product was dissolved in mixture of isohexane-EtOAc (9:1) and a solid was produced which was collected to give the subtitle compound (11.82 g); 1H NMR (CDCl3): 8.05-7.98 (m, 2H), 6.91 (d, IH), 4.55 (s, 2H), 3.96 (s, 3H), 3.89 (s, 3H). LC-MS m/z 260.

The synthetic route of Methyl 4-methoxy-3-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; DAINIPPON SUMITOMO PHARMA CO., LTD; ASTRAZENECA UK LIMITED; BENNETT, Nicholas, James; MCINALLY, Thomas; THOM, Stephen; WO2010/133885; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics