Category: 6962-92-1

Synthetic Route of 6962-92-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6962-92-1, name is 4-Chlorobutyl acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound 10 (0.40 g, 1.4 mmol) and 4-chlorobutyl acetate (0.25 g, 1.7 mmol) were dissolved in dimethyl acetamide (10 ml). Potassium carbonate (0.24 g, 1.7 mmol) and potassium iodide (47.5 mg, 0.286 mmol) were added to the resulting solution, and then the solution was stirred at 70 C. for 6 hours. After cooling the solution to room temperature, 1 N hydrochloric acid was added to the solution, followed by extraction with ethyl acetate. The organic layer obtained by extraction was washed once with saline, and sodium sulfate was added to the washed organic layer. The obtained organic layer was filtered to collect the filtrate, and then the solvent was distilled off from the filtrate under reduced pressure. The resulting residue was purified by flash column chromatography to obtain Compound 11 (0.49 g) in the form of a pale yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chlorobutyl acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FUJIFILM Corporation; FUKUSHIMA, Yuki; GOTO, Ryoji; US2019/177268; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 6962-92-1, These common heterocyclic compound, 6962-92-1, name is 4-Chlorobutyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 6 To an ice-cooled solution of 3-(3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo[1,5-a]pyridine (2.0 g) in N,N-dimethylformamide (20 ml) was added portionwise sodium hydride (60% dispersion in mineral oil; 0.31 g). After addition was finished, the mixture was stirred for 15 minutes in an ice-bath. To this mixture was added 4-chlorobutyl acetate (1.1 g), and the reaction mixture was stirred for 24 hours at room temperature, and then for 36 hours at 70 C. After being cooled to room temperature, the reaction mixture was concentrated. The residue was partitioned between ethyl acetate and water. The organic layer was separated and the aqueous layer was extracted twice with ethyl acetate. The combined organic layers were washed with water and sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and concentrated. Purification of the residue by column chromatography on silica gel (using 3:1 mixture of chloroform and ethyl acetate as eluent) gave 3-[2-(4-acetoxybutyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine (2.6 g). An analytical sample was prepared by recrystallization from diisopropyl ether. mp: 102-103 C. IR (Nujol): 1720, 1660 cm-1 NMR (CDCl3, delta): 1.7-1.9 (2H, m), 1.9-2.2 (2H, m), 2.05 (3H, s), 4.16 (2H, t-like, J=ca. 6Hz), 4.31 (2H, t-like, J=ca. 6Hz), 6.77 (1H, d, J=10Hz), 6.8-7.0 (1H, m), 7.02 (1H, d, J=10Hz), 7.2-7.4 (1H, m), 7.4-7.5 (3H, m), 7.6-7.7 (2H, m), 7.9-8.0 (1H, m), 8.5-8.6 (1H, m) MASS m/z: 402, 343, 287 Anal. Calcd. for C23 H22 N4 O3: C 68.64, H 5.51, N 13.92 (%) Found: C 68.31, H 5.48, N 13.76 (%)

The synthetic route of 6962-92-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5338743; (1994); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6962-92-1, name is 4-Chlorobutyl acetate, A new synthetic method of this compound is introduced below., 6962-92-1

To a suspension of sodium ethoxide (4 g, 59.18 mmol) in EtOM (50 mL) was added thiophenol (5 g, 45.45 mrnol) at0C, followed by drop-wise addition of 4-chiorobutyl acetate (7 g, 45.45 minol) over a period of 20 mm. and stirred the same temperature for 10 mm. and heated at reflux for 6 h. The RM was cooled the reaction to RT, added KOH pellets (2.6 g, 45.45 inmol), heated at reflux for4 h. After completion, the RM was poured into ice water, extracted with EtOAc (2 times), EtOAc layer was washed with water, brine, dried over anhydrous Na2SO4, filtered and the solvent was evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel(60-120 mesh) column chromatography, eluted with 8%EtOAc/pet ether to afford 4-(phenylthio)butan-1-ol as oily mass (6 g, 72%); ?H NMR (400 MHz, cdcl3) 5 7.33 (dd, J = 8.2,1.6 Hz, 2H), 7.30 – 7.23 (m, 2H), 7.20 – 7.14 (m, 1H), 3.65 (td, J = 5.0, 4.1, 3.0 Hz, 2H), 2.96 (t, J = 6.9 Hz, 2H),1.78 – 1.65 (m, 4H); Mass (M+H): 183, LCMS Purity: 99.83%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; NAKASHIMA, Yosuke; JIN, Yoshinobu; WO2014/84407; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

6962-92-1, name is 4-Chlorobutyl acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 6962-92-1

84.5 g of ethyl 4-hydroxybenzoate, 84.2 g of 4-chlorobutyl acetate, 105 g of potassium carbonate and 254 g of N, N-dimethylacetamide were mixed, and the resulting mixture was heated to 100C and stirred. After cooling, methyl isobutyl ketone was added to the reaction mixture, and the mixture was washed with water and then the solvent was removed to obtain 126 g of an oily substance containing the compound (i) as a main component. Yield: 88% (based on ethyl 4-hydroxybenzoate).

Statistics shows that 6962-92-1 is playing an increasingly important role. we look forward to future research findings about 4-Chlorobutyl acetate.

Reference:
Patent; Sumitomo Chemical Co. Ltd.; Ochial, Koshiro; Kobayashi, Tadahiro; (34 pag.)KR101677764; (2016); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

6962-92-1, These common heterocyclic compound, 6962-92-1, name is 4-Chlorobutyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Examples 2 to 13 The process of Example 1 was repeated in a similar manner except that 0.4 mmol of each of the boron compounds as shown in Table 1 was used in place of p-methoxyphenylboronic acid and 0.30 mmol of each organic halide as shown in Table 1 was used in place of 1-bromooctane and reaction was conducted for the noted period of time in Table 1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6962-92-1.

Reference:
Patent; Sumitomo Chemical Co.,Ltd.; EP1439157; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics