Category: 69557-34-2

Yuan, Feipeng; Hou, Zhen-Lin; Pramanick, Pranab K.; Yao, Bo published their research in Organic Letters on December 6 ,2019. The article was titled 《Site-selective modification of α-amino acids and oligopeptides via native amine-directed γ-C(sp3)-H arylation》.COA of Formula: C8H17NO2 The article contains the following contents:

Site-selective modification of chem. and biol. valuable α-amino acids and peptides is of great importance for biochem. study and pharmaceutical development. Few methods based on remote C(sp3)-H functionalization of aliphatic side-chains of peptides has been disclosed in recent years. In this report, we developed a novel approach for γ-C(sp3)-H and γ-/δ-C(sp2)-H arylation of α-amino acids with α-hydrogen by native amine-directed C-H functionalization and further realized the γ-C(sp3)-H arylation of N-terminally unprotected peptides. In the part of experimental materials, we found many familiar compounds, such as Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2COA of Formula: C8H17NO2)

Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. Esters are more polar than ethers but less polar than alcohols. COA of Formula: C8H17NO2 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Ethyl (2S)-2-amino-3,3-dimethylbutanoateOn November 6, 2020 ,《Peptide modification via N-terminal-residue-directed γ-C(sp3)-H arylation》 appeared in Organic Letters. The author of the article were Hou, Zhen-Lin; Yuan, Feipeng; Yao, Bo. The article conveys some information:

Post-assembly modification of peptides via C(sp3)-H functionalization provides an efficient way to prepare functionalized peptides for biol. study and pharmaceutical development. In this work, we developed a new method for γ-C(sp3)-H functionalization of aliphatic side chains of N-terminus-unprotected peptides. With the N-terminal residues as directing groups, a wide range of di-, tri-, tetra-, and pentapeptides underwent C-H arylation of the residues (Val, Ile, Tle) at the +2 position from the N-terminus. The experimental process involved the reaction of Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2Recommanded Product: Ethyl (2S)-2-amino-3,3-dimethylbutanoate)

Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Recommanded Product: Ethyl (2S)-2-amino-3,3-dimethylbutanoate They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Computed Properties of C8H17NO2On September 30, 1997 ,《Protease-catalyzed synthesis of new hydrophobic dipeptides containing non-proteinogenic amino acids》 was published in Enzyme and Microbial Technology. The article was written by Krix, G.; Eichhorn, U.; Jakubke, H. -D.; Kula, M. -R.. The article contains the following contents:

Several dipeptides containing nonproteinogenic amino acids [especially L-tert-leucine or L-neopentylglycine (Npg)] were synthesized enzymically. Thermolysin was used in solid-to-solid conversions in an equilibrium-controlled reaction while α-chymotrypsin was applied in kinetically controlled synthesis. The dipeptide PhCH2O2C-Npg-Npg-NH2 could be obtained using a protease mixture from Streptomyces. The active enzyme has not yet been purified. In the experiment, the researchers used many compounds, for example, Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2Computed Properties of C8H17NO2)

Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Computed Properties of C8H17NO2 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Ethyl (2S)-2-amino-3,3-dimethylbutanoateOn May 31, 1997, Hiroi, Kunio; Hidaka, Akira; Sezaki, Rie; Imamura, Yumiko published an article in Chemical & Pharmaceutical Bulletin. The article was 《Asymmetric induction reactions. VII. Palladium-catalyzed asymmetric α-allylations of carbonyl compounds using chiral sulfonamides as chiral ligands》. The article mentions the following:

Palladium-catalyzed asym. α-allylations of carbonyl compounds were studied using various kinds of chiral sulfonamides derived from optically active α-amino acids as chiral ligands. Participation of the sulfonamide functionality in the palladium catalysis is discussed. After reading the article, we found that the author used Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2Recommanded Product: Ethyl (2S)-2-amino-3,3-dimethylbutanoate)

Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters.Recommanded Product: Ethyl (2S)-2-amino-3,3-dimethylbutanoate They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Aziridine electrophiles in the functionalization of peptide chains with amine nucleophiles》 were Spork, Anatol P.; Donohoe, Timothy J.. And the article was published in Organic & Biomolecular Chemistry in 2015. Synthetic Route of C8H17NO2 The author mentioned the following in the article:

We describe herein the synthesis of aziridine-containing amino acids embedded within tripeptide structures. A range of amine nucleophiles have been shown to open the aziridine amino acid regioselectively at the β-position under mild conditions and without the requirement for a catalyst, forming new adducts in the process. Amino acid N-termini (or an N-containing side-chain) also served as effective nucleophiles for such aziridines and this concept could be extended to encompass a di- or tripeptide nitrogen as a nucleophile, thus providing new methodol. for linking together peptide strands using an amine linker. In the experiment, the researchers used many compounds, for example, Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2Synthetic Route of C8H17NO2)

Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Synthetic Route of C8H17NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jaeger, David A.; Broadhurst, Michael D.; Cram, Donald J. published an article on January 31 ,1979. The article was titled 《Electrophilic substitution at saturated carbon. 52. A model for the proton transfer steps of biological transamination and the effect of a 4-pyridyl group on the base-catalyzed racemization of a carbon acid》, and you may find the article in Journal of the American Chemical Society.Recommanded Product: 69557-34-2 The information in the text is summarized as follows:

Imines (-)-(S)-N-(α-ethoxycarbonylneopentylidene)-α-(4-pyridyl)ethylamine [(-)-I] and (-)-(S)-N-[α-(4-pyridyl)ethylidene]-α-ethoxycarbonylneopentylamine [(-)-II] were prepared in optically pure forms for study as models for the biol. transamination reaction. In tert-Bu alc. at 50°, 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) catalyzed equilibration gave K = II/I >199. Under the same conditions, isomerization of (-)-I to II and racemization of (-)-I occurred at comparable rates. Imine (-)-II resulted, and use of a kinetic model which corrected for concomitant racemization of (-)-I gave a value of 12% for the stereospecificity of the I to II isomerization. Likewise, with (-)-I in pyridine and in DMSO-2H6 with 1,4-diazabicyclo[2.2.2]octane (Dabco) as catalyst at 101.4°, corrected values of 24 and 29% stereospecificity, resp., were obtained for the isomerization of I to II. In each case the stereospecific component of the isomerization was interpreted in terms of the intermediacy of a single, inherently sym. aza-allylic carbanion A asym. ion paired with the conjugate acid of the base. The stereospecific isomerization occurred in cis or suprafacial fashion across the face of carbanion A. Collapse of A favored II over I by a factor of ∼4 in tert-Bu alc.-O-d-DBN, and in the same medium, intramolecularity in the isomerization of I-H to II was 37%. Isotopic exchange reactions of (-)-I and (-)-II were studied in tert-Bu alc.-O-d-DBN, and kc/kα, values of 0.25 and 7, resp., resulted. Thus the isotopic exchange of I occurred with isoinversion and that of II with retention of configuration. The role of the 4-pyridyl group in the isoinversion pathway of (-)-I was analyzed by a study of the isotopic exchange reactions of (-)-(S)-N,N-dimethyl-α-(4-pyridyl)ethylamine (III). Three solvent base systems were used, tert-Bu alc.-O-d-K tert-butoxide at 50.7°, hexamethylphosphoramide-tert-Bu alc.-O-d-DBN at 175°, and MeOH-O-d-K methoxide at 100°, and kc/kα values of 0.75, 0.42, and 1, resp., resulted. In each of the first 2 solvents isoinversion was a contributing mechanistic pathway resulting from the effect of the 4-pyridyl group. In addition to this study using Ethyl (2S)-2-amino-3,3-dimethylbutanoate, there are many other studies that have used Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2Recommanded Product: 69557-34-2) was used in this study.

Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Recommanded Product: 69557-34-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matos, Jeishla L. M.; Vasquez-Cespedes, Suhelen; Gu, Jieyu; Oguma, Takuya; Shenvi, Ryan A. published their research in Journal of the American Chemical Society on December 12 ,2018. The article was titled 《Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes》.Name: Ethyl (2S)-2-amino-3,3-dimethylbutanoate The article contains the following contents:

Radical hydrofunctionalization occurs with ease using metal-hydride hydrogen atom transfer (MHAT) catalysis to couple alkenes and competent radicalophilic electrophiles. Traditional two-electron electrophiles have remained unreactive. Herein we report the reductive coupling of electronically unbiased olefins with imines and aldehydes. Iron catalysis allows addition of alkyl-substituted olefins into imines through the intermediacy of free radicals, whereas a combination of catalytic Co(Salt-Bu,t-Bu) and chromium salts enables a branch-selective coupling of olefins and aldehydes through the formation of a putative alkyl chromium intermediate. The results came from multiple reactions, including the reaction of Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2Name: Ethyl (2S)-2-amino-3,3-dimethylbutanoate)

Ethyl (2S)-2-amino-3,3-dimethylbutanoate(cas: 69557-34-2) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Name: Ethyl (2S)-2-amino-3,3-dimethylbutanoate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics