Category: 6942-37-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6942-37-6, name is Methyl 5-amino-2-bromobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: esters-buliding-blocks

Step B. Preparation of methyl 2-bromo-5-(dimethylamino)benzoateTo a stirred solution of 5-amino-2-bromo-benzoic acid methyl ester (3.30 g, 14.35 mmol) in CH3OH (45 mL) containing CH2O (3.6 mL, 45.0 mmol) at room temperature was added a solution of NaBH3CN (945 mg, 14.35 mmol) and ZnCI2 (990 mg, 7.2 mmol) in CH3OH (45 mL). The reaction mixture was stirred at room temperature overnight, then concentrated. The residue was taken up in 0.1 N NaOH solution, extracted with EtOAc several times. The combined extracts were washed with H2O, brine, dried over dried Na2SO4, then filtered and concentrated. The residue was separated by silica gel column (hexane/EtOAc = 3 : 1) to give 2.991 g (92%) of methyl 2-bromo-5-(dimethylamino)benzoate as a yellow oil based on the partial recovery of (412 mg). methyl 2-bromo-5-(dimethylamino)benzoate, MS: m/z 259 (M + H)

The synthetic route of 6942-37-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; WO2009/120826; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6942-37-6, name is Methyl 5-amino-2-bromobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6942-37-6, Safety of Methyl 5-amino-2-bromobenzoate

To a cooled (5 C.) solution of 48 (4.46 g, 19.4 mmol), pyridine (8 mL, 7.6 g, 97 mmol) in DCM (90 mL) was added dropwise over a period of 20 min a solution of methanesulfonyl chloride (1.65 ml, 2.43 g, 21.3 mmol) in DCM (10 mL). The reaction mixture was stirred at RT overnight and then poured into aq. 1N HCl solution. The resulting solution was extracted with EtOAc, washed with brine, dried (MgSO4), filtered and concentrated to afford 5.7 g (95%) of 50.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-amino-2-bromobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chin, Elbert; Li, Jim; Lui, Albert Sui-Ting; Talamas, Francisco Xavier; US2010/297073; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6942-37-6, name is Methyl 5-amino-2-bromobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6942-37-6, Safety of Methyl 5-amino-2-bromobenzoate

To a cooled (5 C.) solution of 48 (4.46 g, 19.4 mmol), pyridine (8 mL, 7.6 g, 97 mmol) in DCM (90 mL) was added dropwise over a period of 20 min a solution of methanesulfonyl chloride (1.65 ml, 2.43 g, 21.3 mmol) in DCM (10 mL). The reaction mixture was stirred at RT overnight and then poured into aq. 1N HCl solution. The resulting solution was extracted with EtOAc, washed with brine, dried (MgSO4), filtered and concentrated to afford 5.7 g (95%) of 50.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-amino-2-bromobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chin, Elbert; Li, Jim; Lui, Albert Sui-Ting; Talamas, Francisco Xavier; US2010/297073; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 6942-37-6,Some common heterocyclic compound, 6942-37-6, name is Methyl 5-amino-2-bromobenzoate, molecular formula is C8H8BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a solution of the aniline compound (1O g = 43.48 mmol) and triethylamine (TEA. 11.53 ml. = 86.96 mmol) in 100 ml. of toluene, 1 ,4-dibromobutane (10.39 ml. = 86.96 mmol) was added. The reaction mixture was heated to 100 0C for 5 h. The resulting reaction mixture was concentrated, re-diluted with ethyl acetate, washed with saturated NaHCOs aqueous solution and NaCI aqueous solution, dried over MgSO4, then filtered and concentrated. The residue was chromatographed over a 120 g silica column, eluting with 20 % ethyl acetate in hexane to provide 7.1 g of the product 2-(4-pyrrolidin-1-yl-2-methylhydroxy- phenyl)-4,5,6-tetrahydro-thiazolo[4,5-c]pyridin-7-ol as a light yellow solid, MS: m/z 284.1 , 286.1 (M+H).

The synthetic route of 6942-37-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; WO2009/120849; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6942-37-6, name is Methyl 5-amino-2-bromobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Methyl 5-amino-2-bromobenzoate

Step B. Preparation of methyl 2-bromo-5-(dimethylamino)benzoateTo a stirred solution of 5-amino-2-bromo-benzoic acid methyl ester (3.30 g, 14.35 mmol) in CH3OH (45 mL) containing CH2O (3.6 mL, 45.0 mmol) at room temperature was added a solution of NaBH3CN (945 mg, 14.35 mmol) and ZnCI2 (990 mg, 7.2 mmol) in CH3OH (45 mL). The reaction mixture was stirred at room temperature overnight, then concentrated. The residue was taken up in 0.1 N NaOH solution, extracted with EtOAc several times. The combined extracts were washed with H2O, brine, dried over dried Na2SO4, then filtered and concentrated. The residue was separated by silica gel column (hexane/EtOAc = 3 : 1) to give 2.991 g (92%) of methyl 2-bromo-5-(dimethylamino)benzoate as a yellow oil based on the partial recovery of (412 mg). methyl 2-bromo-5-(dimethylamino)benzoate, MS: m/z 259 (M + H)

The synthetic route of 6942-37-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; WO2009/120826; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6942-37-6, name is Methyl 5-amino-2-bromobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6942-37-6, name: Methyl 5-amino-2-bromobenzoate

To a mixture of methyl5-amino-2-bromobenzoate 4a (0.436 g, 1.90 mmol), 2-bromoisobutyric acid 2b (0.479 g, 2.87 mmol) andanhydrous 2-PrOH (4.5 mL) was added Et3N (1.07 mL, 7.68 mmol), and the mixture was stirred for 19 hat 50 C. When the reaction was completed, the reaction mixture was evaporated under vacuum pressure.Water (30 mL) and 1M HCl (5 mL) were added and extracted with AcOEt (15 mL¡Á2). The combinedorganic layer was washed with brine and dried over anhydrous Na2SO4. After filtration, the organicsolution was concentrated to dryness under reduced pressure. The residue was was purified by columnchromatography to afford 9c as a pale yellow solution (0.407 g, 68%). 1H NMR (DMSO-d6, 400 MHz) delta:1.42 (s, 6H), 3.81 (s, 3H), 6.54 (dd, J = 8.8, 3.3 Hz, 1H), 6.88 (d, J = 3.3 Hz, 1H), 7.36 (d, J = 8.8 Hz, 1H),12.47 (s, 1H); 13C NMR (DMSO-d6, 100 MHz) delta: 25.52, 52.36, 56.04, 104.54, 115.26, 117.54, 132.11,133.83, 146.09, 166.57, 176.74; IR (KBr) cm-1: 1032, 1154, 1254, 1334, 1437, 1474, 1601, 1725, 2949,2991, 3388; HRMS (EI): calcd for C12H14BrNO4 [M+]: 315.0106. Found; 315.0090.

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Reference:
Article; Kudo, Kazuhiro; Honda, Takahiro; Yamamoto, Noriyoshi; Heterocycles; vol. 91; 8; (2015); p. 1591 – 1602;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics