Category: 6836-21-1

Related Products of 6836-21-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6836-21-1 name is Ethyl 2-(7-methoxynaphthalen-1-yl)acetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

150 ml of ethanol is loaded into a three-necked reaction flask, magnetically stirred and equipped with a temperature probe, and cooled to 5C. When the temperature of 5C has been reached, 11.3 g of powdered calcium chloride(0.102 mol) is added, followed by 8.2 g of sodium borohydride (0.217 moles). After a few minute stirring at 5C, 10 g of 2-(7-methoxynaphthalen-1-yl)acetic acid ethyl ester 4 (41 mmols), dissolved in 100 ml of anhydrous THF, is added, the temperature being maintained under 10C. At the end of the addition the temperature is increased to room temperature and maintained at that temperature for about 2 hours. 5 ml of water is added slowly at the end of the reaction. 40 ml oftoluene and 20 ml of 30% HCl are then added. The phases are separated by re-extracting the aqueous phase with 20ml of toluene. The combined organic phases are washed with 40 ml of water, and then concentrated under vacuum to dryness to obtain 8.0 g of 2-(7-methoxynaphthalen-1-yl)ethanol 12. Yield 97%. The intermediate obtained was identifiedby NMR analysis: 1H NMR (400 MHz, DMSO-d6) delta 7.83 (d, 2H), 7.70 (m, 1H), 7.36 (m, 2H), 7.27 (m, 1H), 7.18 (m, 1H),3.92 (s, 3H), 3.75 (t, 2H), 3.29 (s, 1H), 3.19 (m, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-(7-methoxynaphthalen-1-yl)acetate, and friends who are interested can also refer to it.

Reference:
Patent; Procos S.p.A.; Barozza, Alessandro; Veronese, Martino; Roletto, Jacopo; Paissoni, Paolo; EP2703383; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6836-21-1, name is Ethyl 2-(7-methoxynaphthalen-1-yl)acetate, A new synthetic method of this compound is introduced below., Product Details of 6836-21-1

Reference example 3: The preparation of 7-methoxy-1-naphthaleneacetic acid 40g sodium hydroxide was dissolved in 1000ml water and 1000ml 95% ethanol was added. They were mixed. Then, 50g ethyl (7-methoxy-1-naphthyl)-acetate was added into above-mentioned mixture solution and the mixture solution was stirred for 3 hours at room temperature. The reaction was subsequently stopped and vacuum evaporated to remove ethanol, resulting in brown-red liquid. The liquid was washed with 300mlx2 ethyl acetate prior to adding 30ml 95% ethanol into the aqueous layer. The pH was adjusted to 2 by adding concentrated hydrochloric acid in drops with rapid stirring, resulting in a large amount of light brown solid being precipitated. They were filtered and dried to obtain 32g product with mp of 154-156C. The content measured by HPLC is 98.48%, and the yield is 72%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Tianjin Taipu Pharmaceutical Science & Technology Development Co., Ltd.; EP2474522; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 6836-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6836-21-1, name is Ethyl 2-(7-methoxynaphthalen-1-yl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 2-(2-methoxy naphthalen-8-yl)acetate (2.0 g, 8.1 mmol)was dissolved in ethanol (40 mL, 20 vol) and cooled to -78 to-74 C, ammonia gas was purged to reaction mass for 30 minat -78 to -74 C, after purging slowly allowed to 25-30 C and stir for 2 h. The reaction mass stored for 48 h at 25-30 C,then mass was concentrated completely under reduced pressureto obtained crude material which was triturated in toluene (20mL, 10 vol) for 1 h and filtered the solid, then washed withtoluene (10 mL, 5 vol) suck dried the compound to get paleyellow coloured solid (1. 5 g, 87.6 % yield).IR (KBr, numax, cm-1): 3395, 3203, 2939, 2831, 1643, 1401,1259, 1203, 1024, 827 ; 1H NMR (400 MHz, DMSO-d6): delta7.84 (d, J = 8.8 Hz, 1H), 7.73 (d, J = 7.0 Hz, 1H), 7.61 (brs,1H), 7.4 (t, J = 6.8 Hz, 2H), 7.28 (t, J = 7.2 Hz, 1H), 7.19 (dd,J1 = 2.0 Hz, J2 = 9.2 Hz, 1H), 7.02 (brs, 1H), 3.87 (s, 3H), 3.81(s, 2H); 13C NMR (100Hz, DMSO-d6): delta 172.14, 157.22,133.14, 131.67, 129.87, 128.65, 128.20, 126.62, 123.01,117.58, 103.37, 55.11; EI-MS m/z (%): 216 (M + 1, 84), 199(27), 171 (100).

The synthetic route of Ethyl 2-(7-methoxynaphthalen-1-yl)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gurunadham; Raju, R. Madhusudhan; Venkateswarlu; Asian Journal of Chemistry; vol. 28; 6; (2016); p. 1367 – 1370;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics